山金车二醇

Arnidiol

	产品编号	CFN93111
	CAS编号	6750-30-7
	分子式 = 分子量	C₃₀H₄₈O₂ = 440.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Tussilago farfara
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
山金车二醇	CFN93111	6750-30-7	1mg	QQ客服：1413575084
山金车二醇	CFN93111	6750-30-7	5mg	QQ客服：1413575084
山金车二醇	CFN93111	6750-30-7	10mg	QQ客服：1413575084
山金车二醇	CFN93111	6750-30-7	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Helsinki (Finland)

Donald Danforth Plant Science Center (USA)

Universidade Federal de Pernambuco (UFPE) (Brazil)

Charles Sturt University (Denmark)

Macau University of Science and Technology (China)

Srinakharinwirot University (Thailand)

University of Lodz (Poland)

University of Auckland (New Zealand)

Medizinische Universit?t Wien (Austria)

Celltrion Chemical Research Institute (Korea)

University Medical Center Mainz (Germany)

Universidad Veracuzana (Mexico)

University of Leipzig (Germany)

Kazusa DNA Research Institute (Japan)

More...

Description:

Arnidiol has anti-inflammatory activity, it possesses marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, the 50% inhibitory dose of these compounds with respect to TPA-inflammation (1 microgram) is 0.03-0.2 mg/ear. Arnidiol shows inhibitory effects against Epstein-Barr virus early antigen (EBV-EA) activation with potencies either comparable with or stronger than that of glycyrrhetic acid, a known natural anti-tumor-promoter; it also possesses a wide range of cytotoxicity against human cancer cell lines, with GI50 values (concentration that yields 50% growth) of mostly less than 6 microM.

Targets:

Immunology & Inflammation related

In vitro:

Cancer Lett., 2002, 177(1):7-12.

Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers.[Pubmed: 11809525]

METHODS AND RESULTS:
Fifteen pentacyclic triterpene diols and triols, consisting of: six taraxastanes, faradiol (1), heliantriol B0 (2), heliantriol C (3), 22alpha-methoxyfaradiol (4), Arnidiol (5), and faradiol alpha-epoxide (6); five oleananes, maniladiol (7), erythrodiol (8), longispinogenin (9), coflodiol (10), and heliantriol A(1) (11); two ursanes, brein (12) and uvaol (13); and two lupanes, calenduladiol (14) and heliantriol B2 (15), isolated from the non-saponifiable lipid fraction of the edible flower extract of chrysanthemum (Chrysanthemum morifolium) were evaluated for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, in Raji cells as a primary screening test for anti-tumor-promoters.
CONCLUSIONS:
All of the compounds tested showed inhibitory effects against EBV-EA activation with potencies either comparable with or stronger than that of glycyrrhetic acid, a known natural anti-tumor-promoter. Evaluation of the cytotoxic activity of six compounds, 1-3 and 5-7, against human cancer cell lines revealed that compound 5 possesses a wide range of cytotoxicity, with GI50 values (concentration that yields 50% growth) of mostly less than 6 microM.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
16alpha-羟基降香醇; 16alpha-Hydroxybauerenol	CFN89447	214351-30-1	C₃₀H₅₀O₂ = 442.71	5mg	QQ客服：1457312923
alpha-乙酸香树脂醇酯; alpha-Amyrin acetate	CFN97423	863-76-3	C₃₂H₅₂O₂ = 468.8	5mg	QQ客服：2056216494
alpha-软脂酸香树精酯; alpha-Amyrin palmitate	CFN98210	22255-10-3	C₄₆H₈₀O₂ = 665.1	5mg	QQ客服：1413575084
伪蒲公英甾醇/(3beta,18alpha,19alpha)-乌苏-20-烯-3-醇; Pseudotaraxasterol	CFN98689	464-98-2	C₃₀H₅₀O = 426.7	5mg	QQ客服：215959384
款冬二醇; Faradiol	CFN93020	20554-95-4	C₃₀H₅₀O₂ = 442.7	5mg	QQ客服：2159513211
蒲公英甾醇; Taraxasterol	CFN99074	1059-14-9	C₃₀H₅₀O = 426.7	20mg	QQ客服：1457312923
蒲公英甾醇醋酸酯; Taraxasterol acetate	CFN97104	6426-43-3	C₃₂H₅₂O₂ = 468.8	5mg	QQ客服：215959384
Taraxasterone; Taraxasterone	CFN89469	6786-16-9	C₃₀H₄₈O = 424.70	5mg	QQ客服：1457312923
山金车二醇; Arnidiol	CFN93111	6750-30-7	C₃₀H₄₈O₂ = 440.7	5mg	QQ客服：1457312923
乙酸降香醇酯; Bauerenol acetate	CFN99808	17020-04-1	C₃₂H₅₂O₂ = 468.8	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2691 mL	11.3456 mL	22.6912 mL	45.3823 mL	56.7279 mL
5 mM	0.4538 mL	2.2691 mL	4.5382 mL	9.0765 mL	11.3456 mL
10 mM	0.2269 mL	1.1346 mL	2.2691 mL	4.5382 mL	5.6728 mL
50 mM	0.0454 mL	0.2269 mL	0.4538 mL	0.9076 mL	1.1346 mL
100 mM	0.0227 mL	0.1135 mL	0.2269 mL	0.4538 mL	0.5673 mL