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  • 阿江榄仁素

    Arjungenin

    阿江榄仁素
    产品编号 CFN95039
    CAS编号 58880-25-4
    分子式 = 分子量 C30H48O6 = 504.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Rudgea viburnioides
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    阿江榄仁素 CFN95039 58880-25-4 1mg QQ客服:1413575084
    阿江榄仁素 CFN95039 58880-25-4 5mg QQ客服:1413575084
    阿江榄仁素 CFN95039 58880-25-4 10mg QQ客服:1413575084
    阿江榄仁素 CFN95039 58880-25-4 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Cornell University (USA)
  • Lund University (Sweden)
  • Shanghai Institute of Organic Chemistry (China)
  • Mendel University in Brno (Czech Republic)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Brasilia (Brazil)
  • Florida International University (USA)
  • S.N.D.T. Women's University (India)
  • University of Indonesia (Indonesia)
  • University of Toronto (Canada)
  • Yale University (USA)
  • University of Hertfordshire (United Kingdom)
  • Regional Crop Research Institute (Korea)
  • Universite de Lille1 (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:352
  • New Zealand J. Forestry Sci.2014, 44:17
  • PLoS One.2015, 10(5):e0127060
  • Acta Biochim Pol.2015, 62(2):253-8
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Br J Pharmacol.2016, 173(2):396-410
  • Phytochem Anal.2016, 27(5):296-303
  • J Pharm Biomed Anal.2017, 140:274-280
  • BMC Complement Altern Med.2017, 17(1):384
  • BMC Complement Altern Med.2017, 17(1):393
  • Br J Pharmacol.2018, 175(6):902-923
  • Biosci Rep.2018, 38(4)
  • Biol Pharm Bull.2018, 41(1):65-72
  • Plant Cell Physiol.2018, 59(1):128-141
  • Planta Med.2018, 84(6-07):465-474
  • Nutrients.2019, 11(4):E936
  • Int J Biol Macromol.2019, 126:653-661
  • Int J Mol Sci.2019, 21(1):E265
  • Food Chem.2019, 274:345-350
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Phytomedicine.2019, 58:152893
  • Planta Med.2019, 85(9-10):766-773
  • Plant Growth Regulation2020, 90(2):383-392
  • ...
  • 生物活性
    Description: Arjungenin shows β-glucuronidase inhibitory activity, it shows antiviral, and anti-inflammatory activities. Arjungenin exhibits moderate antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis (MICs within a range of 64 and 256 ug/mL). Arjungenin shows significant protection against domoic acid induced toxicity in Caco-2 cell line.
    Targets: Immunology & Inflammation related | Antifection
    In vitro:
    Cytotechnology. 2017 Aug;69(4):725-739.
    Modulatory effects of Terminalia arjuna against domoic acid induced toxicity in Caco-2 cell line.[Pubmed: 28342004 ]
    Domoic acid is a potent marine algal toxin produced by diatomic genus of Pseudo-nitzschia causing amnesic shell fish poisoning. Domoic acid toxicosis mainly involves excitotoxic effects coupled with oxidative stress.
    METHODS AND RESULTS:
    The present study was aimed to evaluate the protective effects of hydro-alcoholic extract of Terminalia arjuna (TA) against domoic acid induced toxic effects in Caco-2 cell line. It was observed that the toxicity induced by domoic acid in Caco-2 cells was mediated by oxidative insult leading to morphological changes, DNA damage and apoptosis. In our study pre-treatment of the cells with TA (10, 20 and 30 μg/ml) showed significant protection against domoic acid induced morphological, oxidative and apoptotic damages in a dose dependent manner. The effect of phytocompounds present in TA viz., kaempferol and arjungenin showed significant protection against domoic acid induced toxicity in Caco-2 cell line.
    CONCLUSIONS:
    Hence, it could be inferred that the protective effect of TA extract against domoic acid induced toxicity could be due to the individual or synergistic effects of kaempferol and argungenin. However, further clinical studies are warranted to consider TA as a natural remedy to prevent amnesic shell fish poisoning.
    Fitoterapia. 2016 Apr;110:89-95.
    Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum.[Pubmed: 26946378]
    A new pentacyclic triterpenoid glucoside, together with fourteen known compounds, was isolated from the roots of Combretum racemosum. Combretaceae).
    METHODS AND RESULTS:
    The structure of the new compound was established as 28-O-β-d-glucopyranosyl-2α,3β,21β,23-tetrahydroxyolean-18-en-28-oate (1) on the basis of detailed spectroscopic data including MS, 1D, and 2D NMR. The inhibitory activity of compounds 1-15 against promyelocytic leukemia HL-60 and human erythromyeloblastoid leukemia K562 cell lines was evaluated. Compounds 11 (3-O-β-acetyl-ursolic acid), 14 (betulinic acid), and 15 (quadranoside II) exhibited significant cytotoxicity, with IC50 values of 13 to 50 μM. Among the isolated triterpenes, compounds 1, 3 (arjungenin), 5 (terminolic acid), and 11 exhibited moderate antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis (MICs within a range of 64 and 256 μg/mL).
    Zeitschrift Für Naturforschung B, 2005, 60(3):347-350.
    Some chemical constituents of Terminalia glaucescens and their enzymes inhibition activity.[Reference: WebLink]

    METHODS AND RESULTS:
    A new triterpenoid, glaucinoic acid (2α, 3β, 19α, 24-tetrahydroxyolean-12-en-30-oic acid) (1) along with several known compounds, arjunic acid (2), Arjungenin (3), sericoside (4), and friedelin (5) were isolated from the stem barks of Terminalia glaucescens.
    CONCLUSIONS:
    These compounds showed β-glucuronidase inhibitory activity. The structures were identified on the basis of spectroscopic techniques.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9814 mL 9.9069 mL 19.8138 mL 39.6275 mL 49.5344 mL
    5 mM 0.3963 mL 1.9814 mL 3.9628 mL 7.9255 mL 9.9069 mL
    10 mM 0.1981 mL 0.9907 mL 1.9814 mL 3.9628 mL 4.9534 mL
    50 mM 0.0396 mL 0.1981 mL 0.3963 mL 0.7926 mL 0.9907 mL
    100 mM 0.0198 mL 0.0991 mL 0.1981 mL 0.3963 mL 0.4953 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    远志酸; Polygalic acid CFN92195 1260-04-4 C29H44O6 = 488.7 20mg QQ客服:215959384
    苜蓿酸; Medicagenic acid CFN93933 599-07-5 C30H46O6 = 502.68 5mg QQ客服:2932563308
    远志皂苷元; Senegenin CFN99109 2469-34-3 C30H45ClO6 = 537.14 20mg QQ客服:215959384
    皂皮酸; Quillaic acid CFN96689 631-01-6 C30H46O5 = 486.69 5mg QQ客服:2159513211
    3-beta-O-反式-对-香豆酰马期里酸; 3-beta-O-(trans-p-Coumaroyl)maslinic acid CFN92210 35482-91-8 C39H54O6 = 618.9 5mg QQ客服:2159513211
    3-beta-O-顺式-对-香豆酰马期里酸; 3-beta-O-(cis-p-Coumaroyl)maslinic acid CFN92208 69297-40-1 C39H54O6 = 618.9 5mg QQ客服:1413575084
    Eucalyptolic acid; Eucalyptolic acid CFN92275 189272-68-2 C40H56O7 = 648.9 5mg QQ客服:1148253675
    脱氢山楂酸; Camaldulenic acid CFN96017 71850-15-2 C30H46O4 = 470.7 5mg QQ客服:1148253675
    阿江榄仁酸; Arjunic acid CFN98397 31298-06-3 C30H48O5 = 488.7 5mg QQ客服:3257982914
    阿江榄仁酸; Arjunolic acid CFN98690 465-00-9 C30H48O5 = 488.7 5mg QQ客服:2159513211

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