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  • 牛蒡子苷

    Arctiin

    牛蒡子苷
    产品编号 CFN99991
    CAS编号 20362-31-6
    分子式 = 分子量 C27H34O11 = 534.55
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Arctium lappa L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    牛蒡子苷 CFN99991 20362-31-6 10mg QQ客服:1413575084
    牛蒡子苷 CFN99991 20362-31-6 20mg QQ客服:1413575084
    牛蒡子苷 CFN99991 20362-31-6 50mg QQ客服:1413575084
    牛蒡子苷 CFN99991 20362-31-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • S.N.D.T. Women's University (India)
  • University of Eastern Finland (Finland)
  • Lodz University of Technology (Poland)
  • Universidad Veracuzana (Mexico)
  • Donald Danforth Plant Science Center (USA)
  • Indian Institute of Science (India)
  • Universidad de Buenos Aires (Argentina)
  • Kyoto University (Japan)
  • Northeast Normal University Changchun (China)
  • Nanjing University of Chinese Medicine (China)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Hertfordshire (United Kingdom)
  • Gyeongsang National University (Korea)
  • Universit?t Basel (Switzerland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Molecules.2016, 21(6)
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Phytochemistry.2017, 141:162-170
  • Int J Mol Sci.2017, 18(12)
  • J Ethnopharmacol.2017, 196:75-83
  • Neurochem Int.2018, 121:114-124
  • PLoS One.2018, 13(3):e0193386
  • BMC Plant Biol.2018, 18(1):122
  • BMC Complement Altern Med.2018, 18(1):303
  • Sci Rep. 2018, 1-9
  • Life Sci.2018, 209:498-506
  • Phytomedicine.2018, 40:37-47
  • Planta Med.2018, 84(15):1101-1109
  • Analytical methods2019, 11(6)
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Molecules.2019, 24(1):E159
  • Cell Chem Biol.2019, 26(1):27-34
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Biomed Chromatogr.2019, 8:e4774
  • Neurochem Int.2020, 133:104629
  • Food Chem Toxicol.2020, 135:110863
  • ...
  • 生物活性
    Description: Arctiin(NSC 315527), a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis. Arctiin has been reported to have preventing obesity, antibacterial, antiviral, anti-inflammatory, and anti-oxidant effects in vitro. Arctiin inhibits adipogenesis in 3T3-L1 adipocytes through the inhibition of PPARγ and C/EBPα and the activation of AMPK signaling pathways. Arctiin also has a protective effect on ROS-induced cell dysfunction in HHDPCs and may therefore be useful for alopecia prevention and treatment strategies.
    Targets: PPAR | Fatty Acid Synthase | AMPK | ROS | MAPK | TNF-α | IL Receptor | p65 | NF-kB | IkB | PGE | NO | IKK
    In vitro:
    Biol Res. 2014 Sep 30;47(1):50.
    Arctiin blocks hydrogen peroxide-induced senescence and cell death though microRNA expression changes in human dermal papilla cells.[Pubmed: 25299961]
    Accumulating evidence indicates that reactive oxygen species (ROS) are an important etiological factor for the induction of dermal papilla cell senescence and hair loss, which is also known alopecia. Arctiin is an active lignin isolated from Arctium lappa and has anti-inflammation, anti-microbial, and anti-carcinogenic effects. In the present study, we found that arctiin exerts anti-oxidative effects on human hair dermal papilla cells (HHDPCs).
    METHODS AND RESULTS:
    To better understand the mechanism, we analyzed the level of hydrogen peroxide (H2O2)-induced cytotoxicity, cell death, ROS production and senescence after arctiin pretreatment of HHDPCs. The results showed that arctiin pretreatment significantly inhibited the H2O2-induced reduction in cell viability. Moreover, H2O2-induced sub-G1 phase accumulation and G2 cell cycle arrest were also downregulated by arctiin pretreatment. Interestingly, the increase in intracellular ROS mediated by H2O2 was drastically decreased in HHDPCs cultured in the presence of arctiin. This effect was confirmed by senescence associated-beta galactosidase (SA-β-gal) assay results; we found that arctiin pretreatment impaired H2O2-induced senescence in HHDPCs. Using microRNA (miRNA) microarray and bioinformatic analysis, we showed that this anti-oxidative effect of arctiin in HHDPCs was related with mitogen-activated protein kinase (MAPK) and Wnt signaling pathways.
    CONCLUSIONS:
    Taken together, our data suggest that arctiin has a protective effect on ROS-induced cell dysfunction in HHDPCs and may therefore be useful for alopecia prevention and treatment strategies.
    In vivo:
    Nutr Res Pract. 2014 Dec;8(6):655-61.
    Arctiin inhibits adipogenesis in 3T3-L1 cells and decreases adiposity and body weight in mice fed a high-fat diet.[Pubmed: 25489405]
    The purpose of this study was to examine the effects and associated mechanisms of arctiin, a lignan compound found in burdock, on adipogenesis in 3T3-L1 cells. Also, the effects of arctiin supplementation in obese mice fed a high-fat diet on adiposity were examined.
    METHODS AND RESULTS:
    3T3-L1 cells were treated with arctiin (12.5 to 100 μM) during differentiation for 8 days. The accumulation of lipid droplets was determined by Oil Red O staining and intracellular triglyceride contents. The expressions of genes related to adipogenesis were measured by real-time RT-PCR and Western blot analyses. For in vivo study, C57BL/6J mice were first fed either a control diet (CON) or high-fat diet (HF) to induce obesity, and then fed CON, HF, or HF with 500 mg/kg BW arctiin (HF + AC) for four weeks. Arctiin treatment to 3T3-L1 pre-adipocytes markedly decreased adipogenesis in a dose-dependent manner. The arctiin treatment significantly decreased the protein levels of the key adipogenic regulators PPARγ and C/EBPα, and also significantly inhibited the expression of SREBP-1c, fatty acid synthase, fatty acid-binding protein and lipoprotein lipase. Also, arctiin greatly increased the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream target phosphorylated-acetyl CoA carboxylase. Furthermore, administration of arctiin significantly decreased the body weight in obese mice fed with the high-fat diet. The epididymal, perirenal or total visceral adipose tissue weights of mice were all significantly lower in the HF + AC than in the HF. Arctiin administration also decreased the sizes of lipid droplets in the epididymal adipose tissue.
    CONCLUSIONS:
    Arctiin inhibited adipogenesis in 3T3-L1 adipocytes through the inhibition of PPARγ and C/EBPα and the activation of AMPK signaling pathways. These findings suggest that arctiin has a potential benefit in preventing obesity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8707 mL 9.3537 mL 18.7073 mL 37.4146 mL 46.7683 mL
    5 mM 0.3741 mL 1.8707 mL 3.7415 mL 7.4829 mL 9.3537 mL
    10 mM 0.1871 mL 0.9354 mL 1.8707 mL 3.7415 mL 4.6768 mL
    50 mM 0.0374 mL 0.1871 mL 0.3741 mL 0.7483 mL 0.9354 mL
    100 mM 0.0187 mL 0.0935 mL 0.1871 mL 0.3741 mL 0.4677 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    牛蒡子苷元-4'-O-β-龙胆二糖苷; Arctigenin 4'-O-beta-gentiobioside CFN90714 41682-24-0 C33H44O16 = 696.69 10mg QQ客服:2932563308
    罗汉松脂苷; Matairesinoside CFN89301 23202-85-9 C26H32O11 = 520.53 5mg QQ客服:1413575084
    罗汉松树脂酚-4'-O-β-龙胆二糖苷; Matairesinol 4'-O-beta-gentiobioside CFN90715 106647-14-7 C32H42O16 = 682.25 10mg QQ客服:1148253675
    (-)-Haplomyrfolin; (-)-Haplomyrfolin CFN92253 85404-48-4 C20H20O6 = 356.4 5mg QQ客服:1413575084
    Kusunokinin; Kusunokinin CFN92254 58311-20-9 C21H22O6 = 370.4 5mg QQ客服:2932563308
    裂榄脂素; Bursehernin CFN92058 40456-51-7 C21H22O6 = 370.4 5mg QQ客服:1413575084
    (-)-扁柏脂素,荜澄茄内脂; (-)-Hinokinin CFN92255 26543-89-5 C20H18O6 = 354.4 5mg QQ客服:1148253675
    亚太因; Yatein CFN98635 40456-50-6 C22H24O7 = 400.4 5mg QQ客服:3257982914
    表去甲络石甙元; Epinortrachelogenin CFN92816 125072-69-7 C20H22O7 = 374.4 5mg QQ客服:1413575084
    牛蒡子苷元; Arctigenin CFN99534 7770-78-7 C21H24O6 = 372.41 20mg QQ客服:1148253675

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