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  • 腺华素

    Adenanthin

    腺华素
    产品编号 CFN99215
    CAS编号 111917-59-0
    分子式 = 分子量 C26H34O9 = 490.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Rabdosia adenantha
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
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    腺华素 CFN99215 111917-59-0 1mg QQ客服:2932563308
    腺华素 CFN99215 111917-59-0 5mg QQ客服:2932563308
    腺华素 CFN99215 111917-59-0 10mg QQ客服:2932563308
    腺华素 CFN99215 111917-59-0 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Michigan State University (USA)
  • National Chung Hsing University (Taiwan)
  • University of Indonesia (Indonesia)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Sapienza University of Rome (Italy)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
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  • Lodz University of Technology (Poland)
  • Anna University (India)
  • Rio de Janeiro State University (Brazil)
  • VIT University (India)
  • University of Canterbury (New Zealand)
  • Utrecht University (Netherlands)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Acta Physiologiae Plantarum2016, 38:7
  • Int J Oncol.2016, 49(4):1497-504
  • Braz J Med Biol Res. 2016, 49(7)
  • J Separation Science & Technology2016, 51:1579-1588
  • Biochem Systematics and Ecology2017, 11-18
  • J Ethnopharmacol.2017, 196:75-83
  • Front Plant Sci.2017, 8:723
  • Oncotarget.2017, 9(3):4161-4172
  • Drug Test Anal.2018, 10(10):1579-1589
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Int J Mol Sci.2018, 19(9):E2601
  • Food and Fermentation Industries2018, 44(371)
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Nutrients.2019, 11(6):E1380
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Chemistry of Plant Materials.2019, 215-222
  • Molecules.2019, 24(12):E2286
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Plos One.2019, 15(2):e0220084
  • J Sep Sci.2020, 201901140
  • ...
  • 生物活性
    Description: Adenanthin is a novel NF-κB and nucleophilic cysteines inhibitor, it has bacteriostatic, antiinflammatory, and antitumour activities. Adenanthin also has antileukemic activity through targeting peroxiredoxin I/II. Adenanthin can serve as the development of Prx I– and Prx II–targeted therapeutic agents.
    Targets: NF-kB | ROS | PD-1 | PD-L1 | Prx
    In vitro:
    Cell Death Dis. 2014 Sep 4;5:e1400.
    Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells.[Pubmed: 25188510]
    Adenanthin, has recently been reported to induce leukemic cell differentiation by targeting peroxiredoxins (Prx) I and II. On the other hand, increasing lines of evidence propose that these Prx proteins would become potential targets to screen drugs for the prevention and treatment of solid tumors. Therefore, it is of significance to explore the potential activities of Adenanthin on solid tumor cells.
    METHODS AND RESULTS:
    Here, we demonstrate that Prx I protein is essential for the survival of hepatocellular carcinoma (HCC) cells, and Adenanthin can kill these malignant liver cells in vitro and xenografts. We also show that the cell death-inducing activity of Adenanthin on HCC cells is mediated by the increased reactive oxygen species (ROS) levels. Furthermore, the silencing of Prx I or Prx II significantly enhances the cytotoxic activity of Adenanthin on HCC, whereas the ectopic expression of Prx I and Prx II but not their mutants of Adenanthin-bound cysteines can rescue Adenanthin-induced cytotoxicity in Prxs-silenced HCC cells.
    CONCLUSIONS:
    Taken together, our results propose that Adenanthin targets Prx I/II to kill HCC cells and its therapeutic significance warrants to be further explored in HCC patients.
    Biochem Pharmacol. 2014 May 15;89(2):210-6.
    Adenanthin targets proteins involved in the regulation of disulphide bonds.[Pubmed: 24630929]
    Adenanthin has been recently shown to inhibit the enzymatic activities of peroxiredoxins (Prdx) I and II through its functional α,β-unsaturated ketone group serving as a Michael acceptor. A similar group is found in SK053, a compound recently developed by our group to target the thioredoxin-thioredoxin reductase (Trx-TrxR) system.
    METHODS AND RESULTS:
    This work provides evidence that next to Prdx I and II adenanthin targets additional proteins including thioredoxin-thioredoxin reductase system as well as protein disulfide isomerase (PDI) that contain a characteristic structural motif, referred to as a thioredoxin fold. Adenanthin inhibits the activity of Trx-TR system and PDI in vitro in the insulin reduction assay and decreases the activity of Trx in cultured cells. Moreover, we identified Trx-1 as an adenanthin binding protein in cells incubated with biotinylated adenanthin as an affinity probe.
    CONCLUSIONS:
    The results of our studies indicate that adenanthin is a mechanism-selective, rather than an enzyme-specific inhibitor of enzymes containing readily accessible, nucleophilic cysteines. This observation might be of importance in considering potential therapeutic applications of adenanthin to include a range of diseases, where aberrant activity of Prdx, Trx-TrxR and PDI is involved in their pathogenesis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0383 mL 10.1916 mL 20.3832 mL 40.7664 mL 50.958 mL
    5 mM 0.4077 mL 2.0383 mL 4.0766 mL 8.1533 mL 10.1916 mL
    10 mM 0.2038 mL 1.0192 mL 2.0383 mL 4.0766 mL 5.0958 mL
    50 mM 0.0408 mL 0.2038 mL 0.4077 mL 0.8153 mL 1.0192 mL
    100 mM 0.0204 mL 0.1019 mL 0.2038 mL 0.4077 mL 0.5096 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    苍山香茶菜素; Bulleyanin CFN99347 123043-54-9 C28H38O10 = 534.6 5mg QQ客服:215959384
    蓝萼甲素; Glaucocalyxin A CFN90207 79498-31-0 C20H28O4 = 332.43 20mg QQ客服:3257982914
    Excisanin A; Excisanin A CFN89365 78536-37-5 C20H30O5 = 350.44 5mg QQ客服:2932563308
    凉山香茶菜素A; Liangshanin A CFN99342 122717-54-8 C20H26O4 = 330.4 5mg QQ客服:1148253675
    叶含乙酰瘿花香茶菜素A; Rosthornin A CFN99364 125164-55-8 C22H32O5 = 376.5 5mg QQ客服:3257982914
    叶含乙酰瘿花香茶菜素B; Rosthornin B CFN99365 125181-21-7 C24H34O7 = 434.5 5mg QQ客服:1413575084
    滇杠柳素A; Forrestin A CFN99635 152175-76-3 C30H42O11 = 578.7 5mg QQ客服:3257982914
    毛萼晶A; Maoecrystal A CFN98585 96850-30-5 C22H28O6 = 388.45 10mg QQ客服:2159513211
    尾叶香茶菜戊素; Kamebanin CFN98628 39388-57-3 C20H30O4 = 334.5 5mg QQ客服:2159513211
    香茶菜乙素; Excisanin B CFN97269 78536-36-4 C22H32O6 = 392.5 5mg QQ客服:215959384

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