7-乙基喜树碱

7-Ethylcamptothecin

	产品编号	CFN90336
	CAS编号	78287-27-1
	分子式 = 分子量	C₂₂H₂₀N₂O₄ = 376.41
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The barks of Camptotheca acuminata Decne
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
7-乙基喜树碱	CFN90336	78287-27-1	10mg	QQ客服：1457312923
7-乙基喜树碱	CFN90336	78287-27-1	20mg	QQ客服：1457312923
7-乙基喜树碱	CFN90336	78287-27-1	50mg	QQ客服：1457312923
7-乙基喜树碱	CFN90336	78287-27-1	100mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Amity University (India)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Medizinische Universit?t Wien (Austria)

Lodz University of Technology (Poland)

Istanbul University (Turkey)

University of Wollongong (Australia)

Agricultural Research Organization (ARO) (Israel)

The Australian National University (Australia)

Lund University (Sweden)

University of East Anglia (United Kingdom)

University of Wuerzburg (Germany)

University of Brasilia (Brazil)

University of Madras (India)

Universidad de Buenos Aires (Argentina)

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Description:

7-Ethylcamptothecin has the superior antitumor activity than camptothecin, it has a stronger growth-inhibiting activity against tumor cells and remains in the intestinal tract for a longer time and in higher amounts when administered in vivo.

In vivo:

Cancer Treat Rep. 1987 Apr;71(4):341-8.

Action of 7-ethylcamptothecin on tumor cells and its disposition in mice.[Pubmed: 3829011]

Some biological effects of camptothecin (CPT) and its new derivative 7-Ethylcamptothecin (ECPT) were studied. The drugs were effective against murine leukemia; 7-Ethylcamptothecin was more effective than CPT.
METHODS AND RESULTS:
Ip administration of 7-Ethylcamptothecin or CPT gave maximum treated/control values of 325% and 232%, respectively. The drugs also inhibited the growth of KB cells in vitro, 50% effective doses of 3.5 ng/ml of 7-Ethylcamptothecin and 8.6 ng/ml of CPT, indicating the stronger activity of ECPT. Pharmacokinetic studies of the drugs in mice showed that 7-Ethylcamptothecin had a longer biological half-life in the terminal phase and a larger amount remained in the plasma compared with CPT. After iv administration of 7-Ethylcamptothecin, the drug accumulated in the intestine, suggesting that the main route of excretion of the drug is through the biliary tract. The study on cell cycle progression by flow cytometry suggested that the main effect of both drugs on L1210 cells was the blocking of G2-M phase.
CONCLUSIONS:
These results suggest that the main reasons for the superior antitumor activity of 7-Ethylcamptothecin compared with CPT are as follows: (a) 7-Ethylcamptothecin had a stronger growth-inhibiting activity against tumor cells, and (b) 7-Ethylcamptothecin remained in the intestinal tract for a longer time and in higher amounts when administered in vivo.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
9-氨基喜树碱; 9-Aminocamptothecin	CFN90309	91421-43-1	C₂₀H₁₇N₃O₄ = 363.37	20mg	QQ客服：2056216494
(S)-10-羟基喜树碱; (S)-10-Hydroxycamptothecin	CFN99735	19685-09-7	C₂₀H₁₆N₂O₅ = 364.35	20mg	QQ客服：3257982914
10-甲氧基喜树碱; 10-Methoxycamptothecin	CFN90157	19685-10-0	C₂₁H₁₈N₂O₅ = 378.38	5mg	QQ客服：2159513211
鲁比替康; Rubitecan	CFN93013	91421-42-0	C₂₀H₁₅N₃O₆ = 393.35	5mg	QQ客服：2056216494
10-硝基喜树碱; 10-Nitro-camptothecin	CFN90439	104195-61-1	C₂₀H₁₅N₃O₆ = 393.34	5mg	QQ客服：2056216494
盐酸拓扑替康; Topotecan hydrochloride	CFN90462	119413-54-6	C₂₃H₂₄ClN₃O₅ = 457.9	20mg	QQ客服：2056216494
盐酸依立替康; Irinotecan hydrochloride	CFN90886	100286-90-6	C₃₃H₃₉ClN₄O₆ = 623.2	20mg	QQ客服：3257982914
7-乙基喜树碱; 7-Ethylcamptothecin	CFN90336	78287-27-1	C₂₂H₂₀N₂O₄ = 376.41	20mg	QQ客服：1457312923
7-乙基-10-羟基喜树碱; 7-Ethyl-10-Hydroxycamptothecin	CFN90335	86639-52-3	C₂₂H₂₀N₂O₅ = 392.4	20mg	QQ客服：215959384
9-甲氧基喜树碱; 9-Methoxycamptothecine	CFN99729	39026-92-1	C₂₁H₁₈N₂O₅ = 378.38	20mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6567 mL	13.2834 mL	26.5668 mL	53.1336 mL	66.4169 mL
5 mM	0.5313 mL	2.6567 mL	5.3134 mL	10.6267 mL	13.2834 mL
10 mM	0.2657 mL	1.3283 mL	2.6567 mL	5.3134 mL	6.6417 mL
50 mM	0.0531 mL	0.2657 mL	0.5313 mL	1.0627 mL	1.3283 mL
100 mM	0.0266 mL	0.1328 mL	0.2657 mL	0.5313 mL	0.6642 mL