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  • 6-羟基柳杉酚

    • 6-羟基柳杉酚

    6-Hydroxysugiol

    6-羟基柳杉酚
    		产品编号 CFN92177
    CAS编号 55898-07-2
    分子式 = 分子量 C20H28O3 = 316.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Salvia yunnanensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    6-羟基柳杉酚 CFN92177 55898-07-2 1mg QQ客服：3257982914
    6-羟基柳杉酚 CFN92177 55898-07-2 5mg QQ客服：3257982914
    6-羟基柳杉酚 CFN92177 55898-07-2 10mg QQ客服：3257982914
    6-羟基柳杉酚 CFN92177 55898-07-2 20mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Pharmaceuticals (Basel).2022, 15(8):982.
  • Plant Physiol Biochem.2023, 203:108073.
  • Biomolecules.2023, 13(2):227.
  • Antioxidants (Basel).2022, 11(8):1471.
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  • Pharmaceutics.2022, 14(3):564.
  • Applied Biological Chemistry 2021, 64(75)
  • J Cell Physiol.2020, 10.1002
  • FEMS Microbiol Lett.2017, 364(11)
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • BMB Rep.2020, 53(4):218-222.
  • J Pharmacol Sci.2021, 147(2):184-191.
  • J Microbiol Biotechnol.2022, 32(2):141-148.
  • Inflammation.2021, doi: 10.1007
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • Current Traditional Medicine, 2021, 7:326-335(10).
  • UDC.2020, 19(4).
  • ...
    • 生物活性
    Description: 6-Hydroxysugiol inhibits proliferation and migration of HepG2 cells and exhibits potent anti-angiogenic activity.
    Targets: VEGFR
    In vitro:
    Latin American Journal of Pharmacy, 2012 , 31 (10) :1457-1463.
    6-Hydroxysugiol Isolated from Salvia yunnanensis Inhibits Proliferation and Migration of HepG2 Cells as well as Exhibits Potent Anti-Angiogenic Activity[Reference: WebLink]
    The aim of our study was to investigate the anti-angiogenic effect and anti-tumor activity of 6-Hydroxysugiol isolated from Salvia yunnanensis.
    METHODS AND RESULTS:
    The cell proliferation was evaluated by MTT assay. The apoptosis of HepG2 was studied through the fluorescence microscope. Anti-angiogenic activity of 6-Hydroxysugiol was tested by chicken chorioallantoic membrane (CAM) model in vivo. In order to study the mechanism of 6-Hydroxysugiol inhibiting angiogenesis, the expression of VEGF in the HepG2 cell and the cell culture fluid were determined by immunocytochemistry and ELISA assay. The results showed that the cell proliferation was inhibited to 76.2% by 6-Hydroxysugiol, at the concentration 0.32 mmol/L. The ability of cells to migrate was significantly reduced by 6-Hydroxysugiol and the 59.72% cells showed the typically apoptotic chromatin fragmentation that were treated with 6-Hydroxysugiol at 0.64 mmol/L. The ex- pression of VEGF in the HepG2 cell and in the cell culture medium were all decreased to by 6-Hydroxysugiol.
    CONCLUSIONS:
    6-Hydroxysugiol is able to suppress angiogenesis on CAM models. These results suggest that it is de- served further investigation as a promising anti-tumor angiogenesis compound.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1606 mL 15.8028 mL 31.6056 mL 63.2111 mL 79.0139 mL
    5 mM 0.6321 mL 3.1606 mL 6.3211 mL 12.6422 mL 15.8028 mL
    10 mM 0.3161 mL 1.5803 mL 3.1606 mL 6.3211 mL 7.9014 mL
    50 mM 0.0632 mL 0.3161 mL 0.6321 mL 1.2642 mL 1.5803 mL
    100 mM 0.0316 mL 0.158 mL 0.3161 mL 0.6321 mL 0.7901 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Benzaldehyde; Benzaldehyden CFN92677 1072444-55-3 C20H28O3 = 316.4 5mg QQ客服：3257982914
    弥罗松酚; 铁锈醇; Ferruginol CFN92178 514-62-5 C20H30O = 286.5 5mg QQ客服：1457312923
    15-羟基弥罗松酚; 15-Hydroxyferruginol CFN92329 76235-93-3 C20H30O2 = 302.5 5mg QQ客服：2159513211
    桧醇; Hinokiol CFN98948 564-73-8 C20H30O2 = 302.5 5mg QQ客服：1413575084
    2beta-乙酰弥罗松酚; 2beta-Acetoxyferruginol CFN92978 1206461-56-4 C22H32O3 = 344.49 5mg QQ客服：3257982914
    柳杉酚； 10-脱氧代黄桧醇; Sugiol CFN92187 511-05-7 C20H28O2 = 300.4 5mg QQ客服：3257982914
    6-羟基柳杉酚; 6-Hydroxysugiol CFN92177 55898-07-2 C20H28O3 = 316.4 5mg QQ客服：1413575084
    6-羟基-5,6-去氢柳杉酚; 6-Hydroxy-5,6-dehydrosugiol CFN92149 140923-35-9 C20H26O3 = 314.4 5mg QQ客服：2056216494
    雷公藤酚E; Wilforol E CFN91914 117456-86-7 C21H30O3 = 330.46 5mg QQ客服：2056216494
    Triptonodiol; Triptonodiol CFN96476 117456-87-8 C21H30O4 = 346.46 5mg QQ客服：2056216494

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