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  • 3,23-二氧代-9,19-环羊毛甾-24-烯-26-酸

    3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid

    3,23-二氧代-9,19-环羊毛甾-24-烯-26-酸
    产品编号 CFN97432
    CAS编号 870456-88-5
    分子式 = 分子量 C30H44O4 = 468.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Pseudolarix kaempferi
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3,23-二氧代-9,19-环羊毛甾-24-烯-26-酸 CFN97432 870456-88-5 1mg QQ客服:2932563308
    3,23-二氧代-9,19-环羊毛甾-24-烯-26-酸 CFN97432 870456-88-5 5mg QQ客服:2932563308
    3,23-二氧代-9,19-环羊毛甾-24-烯-26-酸 CFN97432 870456-88-5 10mg QQ客服:2932563308
    3,23-二氧代-9,19-环羊毛甾-24-烯-26-酸 CFN97432 870456-88-5 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Imperial College London (United Kingdom)
  • University of Maryland (USA)
  • University of Lodz (Poland)
  • Regional Crop Research Institute (Korea)
  • Kyoto University (Japan)
  • Universiti Sains Malaysia (Malaysia)
  • University of Illinois (USA)
  • National Research Council of Canada (Canada)
  • Cornell University (USA)
  • Pennsylvania State University (USA)
  • Medical University of South Carolina (USA)
  • Uniwersytet Medyczny w ?odzi (Poland)
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  • Universidade da Beira Interior (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Journal of Chemistry2014, 26(8):2425
  • Oncotarget.2015, 6(31):30831-49
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Molecules.2016, 21(6)
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • Biochem Pharmacol.2017, 130:10-20
  • Molecules.2017, 22(3)
  • Sci Rep.2017, 7:46299
  • Nutrients.2018, 10(12):E1998
  • Front Aging Neurosci.2018, 10:269
  • Anal Chim Acta.2018, 1039:162-171
  • J Pharm Biomed Anal.2018, 151:32-41
  • BMC Complement Altern Med.2018, 18(1):221
  • Exp Parasitol.2018, 194:67-78
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • Front Pharmacol.2019, 10:1226
  • Front Microbiol.2019, 10:2806
  • Mol Microbiol.2019, 112(1):317-332
  • Food and Agriculture Org. Of the UN2019, 151-160
  • J Ethnopharmacol.2019, 228:132-141
  • Environ Toxicol.2019, 34(12):1354-1362
  • Food Chem Toxicol.2020, 135:110863
  • Molecules2020, 25(4):892
  • ...
  • 生物活性
    Description: 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid inhibits the MRCKα kinase with Kd50 of 3.0 uM, it also inhibits the MRCKβ kinase with Kd50 of 3.2 uM; the role of Kinases in cancer onset and progression has made kinases a target for the control of some cancers, suggests that it may possess anticancer activity.
    Targets: MRCK
    In vitro:
    Cancer Res., 2014, 74(19 ):1754-1754.
    Cycloartane anticancer activity[Reference: WebLink]
    New cancer diagnoses remain on the rise despite significant improvements in early detection and treatment. The role of Kinases in cancer onset and progression has made kinases a target for the control of some cancers. The MRCKα/β kinases have recently been implicated in cancer onset and progression and as such could serve as a potential drug target. The discovery that kinases are most effectively inhibited by small molecules has also resulted in an increased search for small molecule kinase inhibitors. Cycloartanes are small molecules found in many medicinal plants including the Jamaican Ball Moss (Tillandsia recurvata). Recent studies on T. recurvata have demonstrated that it possesses significant anticancer activity.Cycloartane-3,24,25-triol, an analog of a cycloartane identified in Ball moss was also shown to have inhibitory activity against MRCKα kinase.
    METHODS AND RESULTS:
    This study was as such set up to determine the MRCKα/β kinase inhibition activity of other cycloartanes in Ball Moss and their analogs. The kinase inhibitory activity of 6 cycloartanes was investigated using the ligand-kinase binding assay while the WST-1 reagent assay was used to determine the antiproliferative activity of the cycloartanes against some prostate and breast cancer cell lines. Cycloart-23-ene-3,25-diol (1), Cycloartane-3,24,25-triol (2), Cycloart-25-ene-3,24-diol (3), 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid (4), 24,25-Dihydroxycycloartan-3-one (5) inhibited the MRCKα kinase with Kd of 0.21 μM, 0.25μM, 0.36 μM, 3.0 μM, and 2.1 μM respectively. Hydroxycycloart-23-en-3-one,25, (6) showed no inhibition against the MRCKα kinase. Compounds 1, 3, 4, 5 inhibited the MRCKβ kinase with Kd of 4.7 μM, 1.10 μM, 3.2 μM, and 9.8 μM, respectively. Three of the six cycloartanes exhibited antiproliferation activity against two prostate and breast cancer cell lines each.
    CONCLUSIONS:
    In conclusion, cycloart-23-ene-3,25-diol (1) showed the most promising activity against the MRCKα/β kinase out of the 6 cycloartanes screened demonstrating an interesting structure activity relationship profile when compared with the other molecules. Cycloart-23-ene-3,25-diol (1) deserves further studies to determine its in vivo efficacy and safety.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1336 mL 10.6678 mL 21.3356 mL 42.6712 mL 53.339 mL
    5 mM 0.4267 mL 2.1336 mL 4.2671 mL 8.5342 mL 10.6678 mL
    10 mM 0.2134 mL 1.0668 mL 2.1336 mL 4.2671 mL 5.3339 mL
    50 mM 0.0427 mL 0.2134 mL 0.4267 mL 0.8534 mL 1.0668 mL
    100 mM 0.0213 mL 0.1067 mL 0.2134 mL 0.4267 mL 0.5334 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    芒果醇酸, (3beta,24E)-3-羟基-9,19-环羊毛甾-24-烯-26-酸; Mangiferolic acid CFN97742 4184-34-3 C30H48O3 = 456.71 5mg QQ客服:3257982914
    异芒果醇酸; Isomangiferolic acid CFN97896 13878-92-7 C30H48O3 = 456.7 5mg QQ客服:215959384
    23-羟基杧果酮酸; 23-Hydroxymangiferonic acid CFN97779 232266-08-9 C30H46O4 = 470.69 5mg QQ客服:2932563308
    3,23-二氧代-9,19-环羊毛甾-24-烯-26-酸 ; 3,23-Dioxo-9,19-cyclolanost-24-en-26-oic acid CFN97432 870456-88-5 C30H44O4 = 468.7 5mg QQ客服:1413575084
    27-羟基杧果醇酸; 27-Hydroxymangiferolic acid CFN97802 17983-82-3 C30H48O4 = 472.71 5mg QQ客服:215959384
    27-羟基杧果酮酸; 27-Hydroxymangiferonic acid CFN97732 5132-66-1 C30H46O4 = 470.69 5mg QQ客服:1413575084

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