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  • 2'-羟基染料木素

    2'-Hydroxygenistein

    2'-羟基染料木素
    产品编号 CFN99257
    CAS编号 1156-78-1
    分子式 = 分子量 C15H10O6 = 286.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Lupinus mutabilis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    2'-羟基染料木素 CFN99257 1156-78-1 1mg QQ客服:1413575084
    2'-羟基染料木素 CFN99257 1156-78-1 5mg QQ客服:1413575084
    2'-羟基染料木素 CFN99257 1156-78-1 10mg QQ客服:1413575084
    2'-羟基染料木素 CFN99257 1156-78-1 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Dicle (Turkey)
  • St. Jude Children Research Hospital (USA)
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  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2015, 20(11):20014-30
  • Acta Biochim Pol.2015, 62(2):253-8
  • Planta Med.2016, 82(13):1208-16
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Fitoterapia.2018, 124:92-102
  • Mol Pharm.2018, 15(8):3285-3296
  • BMC Complement Altern Med.2018, 18(1):303
  • Int J Mol Sci.2018, 19(9):E2681
  • Korean J of Medicinal Crop Science2018, 220-226
  • Anat Rec2018, 24264
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Korean J Environ Agric.2018, 37(4):260-267
  • Korean J Dent Mater.2018, 45(2):139-146
  • Sci Rep. 2018, 462(8)
  • Journal of Life Science2018, 917-922
  • Biomed Pharmacother.2019, 116:108987
  • BMC Complement Altern Med.2019, 19(1):11
  • Molecules.2019, 24(17):E3127
  • Molecules.2019, 24(7):E1290
  • Nat Prod Sci.2019, 25(3):238
  • Srinagarind Medical Journal2019, 34(1)
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • ...
  • 生物活性
    Description: 2'-Hydroxygenistein has antifungal activity, dimerization of it causes a remarkable increase of antifungal activity. It shows significant concentration-dependent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B. 2'-Hydroxygenistein of genistein can enhance its antioxidant activity and cell cytotoxicity in MCF-7 human breast cancer cells.
    Targets: Antifection
    In vitro:
    Phytother Res. 2004 Feb;18(2):128-30.
    Antiplasmodial constituents of Cajanus cajan.[Pubmed: 15022164]

    METHODS AND RESULTS:
    Bioactivity-guided fractionation of extracts of roots and leaves of Cajanus cajan afforded 8 compounds: betulinic acid, biochanin A, cajanol, genistein and 2'-hydroxygenistein, longistylin A and C, and pinostrobin.
    CONCLUSIONS:
    The two stilbenes, longistylin A and C, and betulinic acid showed a moderately high in vitro activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7.
    Bioorg Med Chem Lett. 2004 Feb 23;14(4):1011-4.
    Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica.[Pubmed: 15013012]
    One new isoflavone, 5,7,4'-trihydroxy-2'-methoxyisoflavone (3) and seven, and four known compounds were isolated from the barks of Crotalaria pallida and the seeds of C. assamica, respectively.
    METHODS AND RESULTS:
    The known compounds, apigenin (1) and 2'-Hydroxygenistein (2), isolated from C. pallida, showed significant concentration-dependent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B (fMLP/CB) with IC(50) values of 2.8+/-0.1 and 17.7+/-1.9, and 5.9+/-1.4 and 9.7+/-3.5 microM, respectively. The known compounds, daidzein (4) and 2'-hydroxydaidzein (6), isolated from C. pallida, inhibited of the release of lysozyme and beta-glucuronidase from rat neutrophils in response to fMLP/CB with IC(50) values of 26.3+/-5.5 and 13.7+/-2.6 microM, respectively. Compounds 1 and 4 also showed significant concentration-dependent inhibitory effects on superoxide anion generation in rat neutrophils stimulated with fMLP/CB with IC(50) values of 3.4+/-0.3 and 25.1+/-5.0 microM, respectively. Compounds 1 and 5, previously isolated from C. pallida, showed the inhibition of NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and LPS/interferon-gamma (IFN-gamma)-stimulated N9 microglial cells with IC(50) values of 10.7+/-0.1 and 13.9+/-1.1 microM, respectively.
    CONCLUSIONS:
    Flavonoids, suppressed chemical mediators in inflammatory cells, may have value in treatment and prevention of central and peripheral inflammatory diseases associated with excess production of chemical mediators.
    J Microbiol Biotechnol. 2009 Nov;19(11):1348-54.
    2'-hydroxylation of genistein enhanced antioxidant and antiproliferative activities in mcf-7 human breast cancer cells.[Pubmed: 19996686]

    METHODS AND RESULTS:
    Bioconversion of the isoflavonoid genistein to 2'-Hydroxygenistein (2'-HG) was performed using isoflavone 2'-hydroxylase (CYP81E1) heterologously expressed in yeast. A monohydroxylated product was analyzed by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) and NMR spectrometry and was identified as 2'-HG. An initial bioconversion rate of 6% was increased up to 14% under optimized conditions. After recovery, the biological activity of 2'-HG was evaluated. Bioconverted 2'-HG showed higher antioxidant activity against 1,1- diphenyl-2-picryl hydrazine (DPPH) and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals than did genistein. Furthermore, 2'-HG exhibited greater antiproliferative effects in MCF-7 human breast cancer cells than did genistein.
    CONCLUSIONS:
    These results suggest that 2'- hydroxylation of genistein enhanced its antioxidant activity and cell cytotoxicity in MCF-7 human breast cancer cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4941 mL 17.4703 mL 34.9406 mL 69.8812 mL 87.3515 mL
    5 mM 0.6988 mL 3.4941 mL 6.9881 mL 13.9762 mL 17.4703 mL
    10 mM 0.3494 mL 1.747 mL 3.4941 mL 6.9881 mL 8.7352 mL
    50 mM 0.0699 mL 0.3494 mL 0.6988 mL 1.3976 mL 1.747 mL
    100 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.6988 mL 0.8735 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    木豆异黄酮; 2',4',5-三羟基-7-甲氧基异黄酮; Cajanin CFN98419 32884-36-9 C16H12O6 = 300.3 5mg QQ客服:1413575084
    高淝任素; Homoferreirin CFN97891 482-01-9 C17H16O6 = 316.3 5mg QQ客服:3257982914
    砂生槐异黄酮 A; Sophoraisoflavone A CFN96513 117204-81-6 C20H16O6 = 352.34 5mg QQ客服:1148253675
    甘草异黄烷酮; Licoisoflavanone CFN96544 66067-26-3 C20H18O6 = 354.36 5mg QQ客服:2159513211
    粗毛甘草素F; Glyasperin F CFN94013 145382-61-2 C20H18O6 = 354.35 5mg QQ客服:2932563308
    二氢甘草异黄酮; Dihydrolicoisoflavone CFN95073 164163-92-2 C20H20O6 = 356.4 5mg QQ客服:1413575084
    5,7,2',4'-Tetrahydroxy-8,3'-di(γ,γ-dimethylallyl)-isoflavanone; 5,7,2',4'-Tetrahydroxy-8,3'-di(gamma,gamma-dimethylallyl)-isoflavanone CFN95084 141846-47-1 C25H28O6 = 424.5 5mg QQ客服:1148253675
    2',4'-二羟基-7-甲氧基异黄酮; 5-Deoxycajanin CFN97240 7622-53-9 C16H12O5 = 284.3 5mg QQ客服:1148253675
    2',4',5,7-四羟基异黄烷酮; Dalbergioidin CFN97931 30368-42-4 C15H12O6 = 288.3 5mg QQ客服:2932563308
    2'-羟基染料木素; 2'-Hydroxygenistein CFN99257 1156-78-1 C15H10O6 = 286.2 5mg QQ客服:2932563308

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