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  • 1beta,10beta-Epoxydesacetoxymatricarin

    1beta,10beta-Epoxydesacetoxymatricarin

    1beta,10beta-Epoxydesacetoxymatricarin
    产品编号 CFN89005
    CAS编号 124020-39-9
    分子式 = 分子量 C15H18O4 = 262.30
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Achillea wilhelmsii.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1beta,10beta-Epoxydesacetoxymatricarin CFN89005 124020-39-9 1mg QQ客服:215959384
    1beta,10beta-Epoxydesacetoxymatricarin CFN89005 124020-39-9 5mg QQ客服:215959384
    1beta,10beta-Epoxydesacetoxymatricarin CFN89005 124020-39-9 10mg QQ客服:215959384
    1beta,10beta-Epoxydesacetoxymatricarin CFN89005 124020-39-9 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Amsterdam (Netherlands)
  • Universidade de Franca (Brazil)
  • Michigan State University (USA)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Agricultural Research Organization (ARO) (Israel)
  • Kyushu University (Japan)
  • Copenhagen University (Denmark)
  • University of Brasilia (Brazil)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • University of Oslo (Norway)
  • Monash University Sunway Campus (Malaysia)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Illinois at Chicago (USA)
  • Chang Gung University (Taiwan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Journal of Pharmacognosy2014, 113-120
  • Mol Cells.2015, 38(9):765-72
  • Analytical sci. & Tech2016, 186-193
  • Nat Plants.2016, 3:16205
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • J Chromatogr A.2017, 1518:46-58
  • Int J Mol Sci.2017, 19(1)
  • Universite de Bordeaux2017, 2017BORD0867
  • Srinagarind Medical Journal2017, 32(1)
  • Invest New Drugs.2017, 35(2):166-179
  • Integr Med Res.2017, 6(4):395-403
  • Sci Rep.2017, 7:40345
  • Food Res Int.2018, 106:909-919
  • Neurochem Int.2018, 121:114-124
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Phytomedicine.2018, 40:37-47
  • Phytomedicine.2018, 41:62-66
  • Exp Ther Med.2019, 18(6):4388-4396
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Phytother Res.2019, 33(5):1490-1500
  • Genes Genomics.2020, 10.1007
  • LWT-Food Sci Technol2020, 109163
  • Industrial Crops and Products2020, 146:112186
  • ...
  • 生物活性
    Description: 1beta,10beta-Epoxydesacetoxymatricarin shows high anti-hypercholesterolemic potential.
    Targets: HMG-CoA Reductase | TNF-α | MMP(e.g.TIMP)
    In vivo:
    Molecules. 2016 Mar 25;21(4):404.
    The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.[Pubmed: 27023504 ]
    This study was done to identify the content compounds of Achillea wilhelmsii (A. wilhelmsii) and to evaluate its hypoglycemic and anti-hypercholesterolemic activity and effect on inflammatory mediators.
    METHODS AND RESULTS:
    The extracts and fractions of A. wilhelmsii were thoroughly analyzed using high performance liquid chromatography (HPLC), and the total content of phenols and flavonoids was determined. The hypoglycemic activity was evaluated in vivo using alloxan-induced diabetic mice. The effect upon inflammatory mediators was evaluated in vitro using the human monocytic leukemia cell line (THP-1). The anti-hypercholesterolemic activity was evaluated in vitro using the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase assay kit. The water extract (WE)-treated group showed the highest reduction in the fasting blood glucose levels (FBGL). The chloroform fraction (CF) and ethyl acetate fraction (EAF) both showed a significant ability to reduce the secretion of tumor necrosis factor alpha (TNF-α). The EAF, however, also attenuated the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The CF showed the most significant 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibition activity. The five main compounds in the CF were isolated and identified.
    METHODS AND RESULTS:
    Out of the five compounds in the CF,1beta,10beta-Epoxydesacetoxymatricarin (CP1) and leucodin (CP2) showed the highest anti-hypercholesterolemic potential. A molecular docking study provided corresponding results.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8124 mL 19.0621 mL 38.1243 mL 76.2486 mL 95.3107 mL
    5 mM 0.7625 mL 3.8124 mL 7.6249 mL 15.2497 mL 19.0621 mL
    10 mM 0.3812 mL 1.9062 mL 3.8124 mL 7.6249 mL 9.5311 mL
    50 mM 0.0762 mL 0.3812 mL 0.7625 mL 1.525 mL 1.9062 mL
    100 mM 0.0381 mL 0.1906 mL 0.3812 mL 0.7625 mL 0.9531 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1beta,10beta-Epoxydesacetoxymatricarin; 1beta,10beta-Epoxydesacetoxymatricarin CFN89005 124020-39-9 C15H18O4 = 262.30 5mg QQ客服:2159513211
    Artemyriantholide D; Artemyriantholide D CFN89190 421558-76-1 C30H36O6 = 492.61 5mg QQ客服:3257982914
    去氢木香内酯; Dehydrocostus lactone CFN98720 477-43-0 C15H18O2 = 230.3 20mg QQ客服:215959384
    磺酸基木香烯内酯A; Sulfocostunolide A CFN99030 1016983-51-9 C15H20O5S = 312.4 5mg QQ客服:1148253675
    磺酸基木香烯内酯B; Sulfocostunolide B CFN99075 1059671-65-6 C15H20O5S = 312.4 5mg QQ客服:2932563308
    1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide; 1alpha,4beta,10beta-Trihydroxyguaia-2,11(13)-dien-12,6alpha-olide CFN89195 221148-94-3 C15H20O5 = 280.32 5mg QQ客服:2159513211
    林泽兰内酯B; Eupalinilide B CFN90378 757202-08-7 C20H24O6 = 360.41 10mg QQ客服:2159513211
    林泽兰内酯C; Eupalinilide C CFN90379 757202-11-2 C20H24O7 = 376.4 5mg QQ客服:2159513211
    林泽兰内酯D; Eupalinilide D CFN90380 757202-14-5 C15H19ClO5 = 314.76 10mg QQ客服:1148253675
    8-Epicrepiside E; 8-Epicrepiside E CFN96796 93395-30-3 C21H28O9 = 424.44 5mg QQ客服:1148253675

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