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  • 樱桃甙; 洋李甙

    Prunin

    樱桃甙; 洋李甙
    产品编号 CFN98878
    CAS编号 529-55-5
    分子式 = 分子量 C21H22O10 = 434.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The heartwoods of Podocarpus macrophyllus.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    樱桃甙; 洋李甙 CFN98878 529-55-5 1mg QQ客服:2159513211
    樱桃甙; 洋李甙 CFN98878 529-55-5 5mg QQ客服:2159513211
    樱桃甙; 洋李甙 CFN98878 529-55-5 10mg QQ客服:2159513211
    樱桃甙; 洋李甙 CFN98878 529-55-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of the Basque Country (Spain)
  • Aarhus University (Denmark)
  • Washington State University (USA)
  • University of Bordeaux (France)
  • Wroclaw Medical University (Poland)
  • St. Jude Children Research Hospital (USA)
  • University of Liège (Belgium)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Indian Institute of Science (India)
  • Universidad de Buenos Aires (Argentina)
  • Deutsches Krebsforschungszentrum (Germany)
  • Northeast Normal University Changchun (China)
  • University of Cincinnati (USA)
  • National Hellenic Research Foundation (Greece)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Immunol.2020, 11:598556.
  • Institute of Food Science & Technology2021, 18 December.
  • Mol Pharmacol.2021, 99(2):163-174.
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • J Nat Med.2017, 71(4):745-756
  • J Pharmaceut Biomed2020, 182:113110
  • Appl Microbiol Biotechnol.2018, 102(12):5105-5120
  • Anat Rec2018, 24264
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Int J Biol Macromol.2018, 112:1093-1103
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • Eur J Pharm Sci.2016, 94:33-45
  • mBio.2020, 11(3):e00686-20.
  • JAOCS2021, 98(7):779-794.
  • Chinese Medicine2019, 14(1)
  • Nutrients.2018, 10(12):E1998
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • HIV Med.2021, 22(8):690-704.
  • BMC Complement Altern Med.2014, 14:242
  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.
  • Molecules2020, 25(4):892
  • Molecules 2022, 27(3),1047.
  • Korean J Dent Mater2020, 47(2):63-70.
  • ...
  • 生物活性
    Description: Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can stimulate growth of Pseudomonas aeruginosa and different Bacilllus sp. Prunin exhibits a markedly enhanced solubility compared to naringenin and naringin while maintaining the in vitro inhibition of HMG-CoA reductase.
    Targets: HMG-CoA reductase | Antifection
    In vitro:
    Food Chem Toxicol. 2013 May;55:411-23.
    Prunin- and hesperetin glucoside-alkyl (C4-C18) esters interaction with Jurkat cells plasma membrane: consequences on membrane physical properties and antioxidant capacity.[Pubmed: 23354392 ]
    Prunin (P)- and hesperetin glucoside (HG)-alkyl esters are lipid-soluble compounds with antimicrobial and antioxidant capacities in vitro.
    METHODS AND RESULTS:
    The effects of Prunin- and HG-alkyl (C4-C18) esters (0.1-100μM) on human leukemia T (Jurkat) cells viability and plasma membrane fluidity were evaluated. At this concentration, cell hyperpolarization and shrinkage were also observed. Cell plasma membrane fluidity was not affected, regardless the depths of the membrane level evaluated, but mild changes in plasma membrane hydration were found. Esterification did not affect the antioxidant capacity of Prunin and HG (0.1-10μM) against 1mM H2O2. When exposed to 1mM AAPH, P-alkyl esters retained Prunin antioxidant capacity, but HG-derivatives acted as pro-oxidants.
    CONCLUSIONS:
    Together, present experimental evidences suggest that short term exposures to 0.1-10μM concentrations of Prunin- and HG-alkyl (C4-C18) esters can be considered safe for cultured human cells, and further studies are required to investigate their long term effects, as well their safety for human consumption.
    Food Chemistry, 2011, 124(1):234-241.
    Purification and characterisation of Aspergillus sojae naringinase: The production of prunin exhibiting markedly enhanced solubility with in vitro inhibition of HMG-CoA reductase.[Reference: WebLink]
    Aspergillus sojae isolated from a traditional Korean fermented soybean product exhibited strong naringinase activity.
    METHODS AND RESULTS:
    The naringinase enzyme was purified and had a molecular weight of 70kDa. The α-l-rhamnosidase activity of this enzyme was optimal at pH 6.0 and stable in the pH range of 5.5-8.0. The purified enzyme also had β-d-glucosidase activity, but the activity was relatively weak compared to the activity of the naringinase from Penicillium decumbens. The enzymatic bioconversion by A. sojae naringinase of naringin to Prunin was efficiently performed with a 91% yield and a negligible amount of naringenin. The bioconversion was achieved by repetitive batch reactions with enzyme recycling. Prunin exhibited a markedly enhanced solubility compared to naringenin and naringin while maintaining the in vitro inhibition of HMG-CoA reductase.
    CONCLUSIONS:
    The results reported in this paper show that the naringinase produced by A. sojae will be useful in enhancing the potential bioavailability of naringin by efficiently converting it to Prunin as a food component in citrus.
    J Appl Microbiol. 2010 Oct;109(4):1450-7.
    Antimicrobial properties of prunin, a citric flavanone glucoside, and its prunin 6″-O-lauroyl ester.[Pubmed: 20553344]
    To determine the antimicrobial potential of Prunin (P), a flavanone glucoside resulting from the hydrolysis of naringin present in grapefruit, and of its Prunin 6″-O-lauroyl ester (PL), synthesized by enzymatic catalysis.
    METHODS AND RESULTS:
    P and its lauroyl ester were tested against Gram-negative and Gram-positive bacteria, yeasts and moulds.Prunin showed no inhibitory effect against the micro-organisms assayed, but stimulated growth of Pseudomonas aeruginosa and different Bacilllus sp. A bactericidal effect was also determined on L. monocytogenes sensitive and bacteriocin-resistant mutant strains.Prunin did not show any antimicrobial property at all.
    CONCLUSIONS:
    PL is a potential antimicrobial compound with a high anti-Listeria property.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.302 mL 11.5101 mL 23.0203 mL 46.0405 mL 57.5506 mL
    5 mM 0.4604 mL 2.302 mL 4.6041 mL 9.2081 mL 11.5101 mL
    10 mM 0.2302 mL 1.151 mL 2.302 mL 4.6041 mL 5.7551 mL
    50 mM 0.046 mL 0.2302 mL 0.4604 mL 0.9208 mL 1.151 mL
    100 mM 0.023 mL 0.1151 mL 0.2302 mL 0.4604 mL 0.5755 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柚皮芸香苷; Narirutin CFN99543 14259-46-2 C27H32O14 = 580.53 20mg QQ客服:1413575084
    芸香柚皮苷 4'-葡萄糖苷; Narirutin 4'-glucoside CFN95421 17257-22-6 C33H42O19 = 742.7 10mg QQ客服:3257982914
    Pyrroside B; Pyrroside B CFN96142 116271-35-3 C26H30O14 = 566.5 5mg QQ客服:3257982914
    柚皮素-7-O-龙胆二糖苷; Naringenin 7-O-gentiobioside CFN95435 104154-33-8 C27H32O15 = 596.5 5mg QQ客服:1148253675
    5,6,7,4'-四羟基黄酮 6,7-二葡萄糖苷; 5,6,7,4'-Tetrahydroxyflavanone 6,7-diglucoside CFN92520 501434-65-7 C27H32O16 = 612.5 5mg QQ客服:2159513211
    异樱花苷; Isosakuranin CFN92809 491-69-0 C22H24O10 = 448.1 10mg QQ客服:1413575084
    枸橘苷; Poncirin CFN90448 14941-08-3 C28H34O14 = 594.56 20mg QQ客服:2932563308
    香风草甙; Didymin CFN92363 14259-47-3 C28H34O14 = 594.6 20mg QQ客服:1148253675
    半皮桉苷; Hemiphloin CFN91855 71963-94-5 C21H22O10 = 434.4 5mg QQ客服:2159513211
    异柚葡糖苷; Isohemiphloin CFN98602 3682-02-8 C21H22O10 = 434.4 5mg QQ客服:215959384

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