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  • 柚皮芸香苷

    Narirutin

    柚皮芸香苷
    产品编号 CFN99543
    CAS编号 14259-46-2
    分子式 = 分子量 C27H32O14 = 580.53
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The young fruits of Citrus grandis (L.) Osbeck.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柚皮芸香苷 CFN99543 14259-46-2 10mg QQ客服:2932563308
    柚皮芸香苷 CFN99543 14259-46-2 20mg QQ客服:2932563308
    柚皮芸香苷 CFN99543 14259-46-2 50mg QQ客服:2932563308
    柚皮芸香苷 CFN99543 14259-46-2 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medizinische Universit?t Wien (Austria)
  • University of Liège (Belgium)
  • University of Beira Interior (Portugal)
  • Griffith University (Australia)
  • University of South Australia (Australia)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • University of Vigo (Spain)
  • FORTH-IMBB (Greece)
  • University of Minnesota (USA)
  • The Institute of Cancer Research (United Kingdom)
  • Shanghai Institute of Organic Chemistry (China)
  • Melbourne University (Australia)
  • Anna University (India)
  • University of Perugia (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Research Square2020, doi: 10.21203.
  • Korean Herb. Med. Inf.2021, 9(2):231-239.
  • Molecules.2021, 26(3):695.
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • BMC Plant Biol.2020, 20(1):214.
  • Sustainability2021, 13(23),12981.
  • Phytomedicine.2018, 40:37-47
  • RSC Adv.2018, 32621-32636
  • Molecules.2016, 21(6)
  • Int J Mol Med.2016, 37(2):501-8
  • Foods.2021, 10(12):2929.
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Oxid Med Cell Longev.2021, 2021:6647107.
  • Front Plant Sci.2022, 13: 905275.
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Research J. Pharm. and Tech.2020, 13(7):3059-3064.
  • Plant Direct.2021, 5(12):e372.
  • J Med Food.2021, 24(3):209-217.
  • Food Res Int.2020, 128:108778
  • Oncotarget.2017, 9(3):4161-4172
  • Nutrients2022, 14(3),695.
  • Molecules2021, 26(1),230
  • Food Chem.2021, 360:130063.
  • ...
  • 生物活性
    Description: Citrus narirutin fraction (CNF), contained 75% of narirutin, co-administration of CNF with alcohol can alleviate alcohol induced liver damage through preventing lipid formation, protecting antioxidant system and suppressing productions of pro-inflammatory cytokines. Narirutin has anti-inflammatory effect in a murine model of allergic eosinophilic airway inflammation, the mechanism is likely to be associated with a reduction in the OVA-induced increases of IL-4 and IgE.
    Targets: NO | NOS | PGE | COX | TNF-α | NF-kB | MAPK | IL Receptor
    In vitro:
    Food Chem Toxicol. 2012 Oct;50(10):3498-504.
    Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MAPKs activation.[Pubmed: 22813871]

    METHODS AND RESULTS:
    In this study, we examined the regulatory activity of narirutin fraction from citrus peels on the production of inflammatory mediators managing acute or chronic inflammatory diseases in macrophages. Narirutin fraction inhibited the release, by lipopolysaccharide (LPS)-stimulated macrophages, of nitric oxide (NO) and prostaglandin E2 (PGE2) through suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively. The release, by LPS stimulated macrophages, of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) was also reduced by narirutin fraction in a dose-dependent manner. Furthermore, narirutin fraction inhibited the LPS-mediated activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinases (MAPKs), which are signaling molecules involved in production of pro-inflammatory factors.
    CONCLUSIONS:
    As a result of these properties, narirutin fraction has the potential to be used as a functional dietary supplement and effective anti-inflammatory agent.
    Curr Comput Aided Drug Des . 2020;16(5):523-529.
    Structure-based Discovery of Narirutin as a Shikimate kinase Inhibitor with Anti-tubercular Potency[Pubmed: 31654517]
    Abstract Background: Shikimate pathway is essential for tubercular bacillus but it is absent in mammals. Therefore, Shikimate kinase and other enzymes in the pathway are potential targets for the development of novel anti-tuberculosis drugs. Objective: In the present study, Shikimate kinase is selected as the target for in silico screening of phytochemicals with an aim to discover a novel herbal drug against Mycobacterium tuberculosis (Mtb). Methods: A structure-based drug discovery approach is undertaken for the execution of the objective. Virtual screening of phytochemical database NPACT against the target, Shikimate kinase (PDB ID 3BAF), is carried out followed by toxicity and drug-likeness filtration. Finally, a lead, narirutin was selected for in vitro anti-tubercular study. Results: Narirutin, present in citrus fruits, emerges as the lead. It is considered to be non-toxic with predicted high LD50 value, 12000 mg/kg body weight. The phytochemical is tested for its antitubercular activity in vitro. It has MIC99 62.5 μg/mL against the MtbH37Rv strain. Conclusion: This is the first-ever report to show anti-tuberculosis potency of narirutin. Keywords: Molecular docking; Mycobacterium tuberculosis; drug-likeness; narirutin; shikimate kinase; toxicity.
    In vivo:
    Food Chem Toxicol. 2013 May;55:637-44.
    Narirutin fraction from citrus peels attenuates alcoholic liver disease in mice.[Pubmed: 23416143]

    METHODS AND RESULTS:
    This study aimed to demonstrate protective activities of the narirutin fraction from peels of Citrus unshiu against ethanol-induced hepatic damage through an animal study. Citrus narirutin fraction (CNF), contained 75% of narirutin, was obtained by an ultra-sonicated extraction and further purification. ICR mice were divided into four groups; normaldiet control, ethanol control (6.5g ethanol/kg), low-CNF (ethanol+150mg CNF/kg) and high-CNF (ethanol+300mg CNF/kg) groups. Consumption of alcohol for 8weeks induced severe liver damage with increases in prognostic indicators such as aspartate transaminase, alanine transaminase in serum whereas co-administration of CNF suppressed their increases. Excessive accumulations in liver TG and TC in ethanol control group were also suppressed by co-administration of CNF. Co-administration of CNF maintained SOD activity, GSH and malondialdehyde levels close to those of the normal diet group. Chronic consumption of alcohol also stimulated abrupt increases in pro-inflammatory cytokines such as nuclear factor (NF)-κB, tumor necrosis factor (TNF)-α and interleukin (IL)-1β in liver otherwise co-administration of CNF effectively suppressed production of these cytokines dose-dependently.
    CONCLUSIONS:
    These results indicate that co-administration of CNF with alcohol can alleviate alcohol induced liver damage through preventing lipid formation, protecting antioxidant system and suppressing productions of pro-inflammatory cytokines.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7226 mL 8.6128 mL 17.2256 mL 34.4513 mL 43.0641 mL
    5 mM 0.3445 mL 1.7226 mL 3.4451 mL 6.8903 mL 8.6128 mL
    10 mM 0.1723 mL 0.8613 mL 1.7226 mL 3.4451 mL 4.3064 mL
    50 mM 0.0345 mL 0.1723 mL 0.3445 mL 0.689 mL 0.8613 mL
    100 mM 0.0172 mL 0.0861 mL 0.1723 mL 0.3445 mL 0.4306 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    芹糖甘草苷; Liquiritin apioside CFN90707 199796-12-8 C26H30O13 = 550.5 20mg QQ客服:2932563308
    葡萄糖基甘草苷; Glucoliquiritin CFN95011 93446-18-5 C27H32O14 = 580.5 10mg QQ客服:215959384
    樱桃甙; 洋李甙; Prunin CFN98878 529-55-5 C21H22O10 = 434.4 10mg QQ客服:1148253675
    柚皮苷; Naringin CFN99555 10236-47-2 C27H32O14 = 580.53 20mg QQ客服:2159513211
    6''-乙酰柚皮苷; Naringin 6''-acetate CFN95418 139934-60-4 C29H34O15 = 622.6 5mg QQ客服:1413575084
    Melitidin; Melitidin CFN95419 1162664-58-5 C33H40O18 = 724.7 10mg QQ客服:2932563308
    Theaflavanoside II; Theaflavanoside II CFN95380 943785-09-9 C32H40O18 = 712.6 5mg QQ客服:215959384
    柚皮苷 4'-葡萄糖苷; Naringin 4'-glucoside CFN95014 17257-21-5 C33H42O19 = 742.7 5mg QQ客服:3257982914
    Bergamjuicin; Bergamjuicin CFN95422 2376307-20-7 C39H50O23 = 886.8 5mg QQ客服:2159513211
    柚皮芸香苷; Narirutin CFN99543 14259-46-2 C27H32O14 = 580.53 20mg QQ客服:1148253675

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