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  • (+)-南烛木树脂酚

    (+)-Lyoniresinol

    (+)-南烛木树脂酚
    产品编号 CFN99488
    CAS编号 14464-90-5
    分子式 = 分子量 C22H28O8 = 420.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Vitex negundo
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (+)-南烛木树脂酚 CFN99488 14464-90-5 1mg QQ客服:1413575084
    (+)-南烛木树脂酚 CFN99488 14464-90-5 5mg QQ客服:1413575084
    (+)-南烛木树脂酚 CFN99488 14464-90-5 10mg QQ客服:1413575084
    (+)-南烛木树脂酚 CFN99488 14464-90-5 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Georgia Institute of Technology (USA)
  • University of British Columbia (Canada)
  • Northeast Normal University Changchun (China)
  • Chinese University of Hong Kong (China)
  • Florida International University (USA)
  • Deutsches Krebsforschungszentrum (Germany)
  • Washington State University (USA)
  • University of Virginia (USA)
  • University of Wuerzburg (Germany)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Griffith University (Australia)
  • University of Lodz (Poland)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules2022, 27(14),4462
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Phytochem Anal.2021, 32(6):970-981.
  • Phytomedicine.2020, 153440.
  • Asian Pac J Cancer Prev.2021, 22(S1):97-106.
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • Int J Mol Sci.2021, 22(16):8641.
  • J of Physics Conference Series2019, 1349(1)
  • Metabolites.2020, 11(1):E11.
  • Natural Product Communications2020, doi: 10.1177.
  • BMB Rep.2020, 53(4):218-222.
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • Int J Pharm.2022, 618:121636.
  • Sci Rep.2015, 5:13194
  • Crystals2020, 10(3), 206.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2021, 1187:123012.
  • Bull. Natl. Mus. Nat. Sci.2021, 47(2),109-114.
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • J Anal Toxicol.2021, bkab015.
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • J Drug Target.2016, 24:1-28
  • Planta Med.2016, 82(13):1208-16
  • Srinagarind Medical Journal2019, 34(1)
  • ...
  • 生物活性
    Description: Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulated MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression.
    Targets: ERK | TRP
    In vitro:
    Arch Pharm Res. 2005 Sep;28(9):1031-6.
    Antimicrobial property of (+)-lyoniresinol-3alpha-O-beta-D-glucopyranoside isolated from the root bark of Lycium chinense Miller against human pathogenic microorganisms.[Pubmed: 16212233]

    METHODS AND RESULTS:
    (+)-Lyoniresinol-3alpha-O-beta-D-glucopyranoside (1) was isolated from an ethyl acetate extract of the root bark from Lycium chinense Miller, and its structure was determined using 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC. (+)-Lyoniresinol-3alpha-O-beta-D-glucopyranoside exhibited potent antimicrobial activity against antibiotic-resistant bacterial strains, methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients, and human pathogenic fungi without having any hemolytic effect on human erythrocytes. In particular, compound 1 induced the accumulation of intracellular trehalose on C. albicans as stress response to the drug, and disrupted the dimorphic transition that forms pseudo-hyphae caused by the pathogenesis.
    CONCLUSIONS:
    This indicates that (+)-Lyoniresinol-3alpha-O-beta-D-glucopyranoside has excellent potential as a lead compound for the development of antibiotic agents.
    Mol Cell Biochem. 2013 Jan;373(1-2):211-6.
    Lyoniresinol inhibits melanogenic activity through the induction of microphthalmia-associated transcription factor and extracellular receptor kinase activation.[Pubmed: 23099844 ]
    Lyoniresinol was one of the eight lignans purified from methanol extract of Vitex negundo and was shown to have robust tyrosinase inhibitory capacity. However, the mechanism of its action is not known.
    METHODS AND RESULTS:
    Hence, the goal of the current study was to study the effects of Lyoniresinol on cytotoxicity and melanin content in murine B16F10 melanoma cells and to delineate the underlying mechanism of tyrosinase inhibition. Lyoniresinol was purified from methanol extract of Vitex negundo root and when tested in B16F10, cells showed robust anti-melanogenic activity. It caused the downregulation of microphthalmia-associated transcription factor (MITF) and tyrosinase steady state protein expression levels. Flow cytometry analysis of Lyoniresinol-treated cells showed that the latter activates extracellular receptor kinase (ERK) phosphorylation, which causes MITF protein degradation and suppression of tyrosinase activity. Lyoniresinol decreased tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signaling, which downregulated MITF, tyrosinase, but not TRP-1 and TRP-2 protein expression.
    CONCLUSIONS:
    Contingent to more vigorous in vitro and in vivo experiments, Lyoniresinol can perhaps be incorporated into clinical dermatologic use as a skin lightening agent.
    West African J. Med., 1994, 13(1):495-8.
    Changes in Lyoniresinol Content and Antioxidative Activity of Pickled Ume during the Seasoning Process[Reference: WebLink]
    Lyoniresinol content and antioxidative activity of commercially available seasoning pickled Ume was investigated.
    METHODS AND RESULTS:
    The seasoning pickled Ume with low salt concentration showed relatively low lyoniresinol content and antioxidative activity compared to products with high salt concentrations. This result indicates that excessive de-salt operation leads to decrease of a lyoniresinol content and antioxidative activity of flesh. Although remarkable decrease of lyoniresinol content and antioxidative activity of pickled Ume was observed in the early stage of seasoning process, re-extraction of lyoniresinol and antioxidative activity by osmotic pressure of seasoning liquid was thought to occur after two weeks and later.
    CONCLUSIONS:
    From the results obtained, we concluded that enough period seasoning by the seasoning liquid with enough osmotic pressure is necessary to produce the seasoning pickled Ume with rich nutritional function.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3781 mL 11.8906 mL 23.7812 mL 47.5624 mL 59.453 mL
    5 mM 0.4756 mL 2.3781 mL 4.7562 mL 9.5125 mL 11.8906 mL
    10 mM 0.2378 mL 1.1891 mL 2.3781 mL 4.7562 mL 5.9453 mL
    50 mM 0.0476 mL 0.2378 mL 0.4756 mL 0.9512 mL 1.1891 mL
    100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.4756 mL 0.5945 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (-)-Lyoniresinol 9'-O-glucoside ; (-)-Lyoniresinol 9'-O-glucoside CFN96732 143236-02-6 C28H38O13 = 582.59 5mg QQ客服:3257982914
    Nudiposide; Nudiposide CFN89146 62058-46-2 C27H36O12 = 552.57 5mg QQ客服:3257982914
    异紫杉脂素9,9'-缩丙酮; Isotaxiresinol 9,9'-acetonide CFN97774 252333-72-5 C22H26O6 = 386.44 5mg QQ客服:1148253675
    异橄榄树脂素; Cycloolivil CFN96185 3064-05-9 C20H24O7 = 376.4 5mg QQ客服:1413575084
    异落叶松脂素; Isolariciresinol CFN98915 548-29-8 C20H24O6 = 360.4 5mg QQ客服:1413575084
    9,9'-O-Isopropyllidene-isolariciresinol; 9,9'-O-Isopropyllidene-isolariciresinol CFN98276 252333-71-4 C23H28O6 = 400.5 5mg QQ客服:1148253675
    异落叶松脂素 9'-beta-D-吡喃木糖苷; Schizandriside CFN96693 71222-06-5 C25H32O10 = 492.52 5mg QQ客服:1413575084
    (-)-异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-Isolariciresinol 9'-O-glucoside CFN89431 143236-04-8 C26H34O11 = 522.54 5mg QQ客服:1413575084
    Vitexdoin A; Vitexdoin A CFN96194 1186021-77-1 C19H18O6 = 342.4 5mg QQ客服:2159513211
    7,8,9,9-四脱氢异落叶松树脂酚; 7,8,9,9-Tetradehydroisolariciresinol CFN99605 145918-59-8 C20H20O6 = 356.4 5mg QQ客服:1148253675

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