Info: Read More
  • 中药标准品生产商,产品定制服务
  • 羽扇烯酮

    Lupenone

    羽扇烯酮
    产品编号 CFN99681
    CAS编号 1617-70-5
    分子式 = 分子量 C30H48O = 424.7
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The roots of Pueraria thomsonii Benth.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    羽扇烯酮 CFN99681 1617-70-5 1mg QQ客服:215959384
    羽扇烯酮 CFN99681 1617-70-5 5mg QQ客服:215959384
    羽扇烯酮 CFN99681 1617-70-5 10mg QQ客服:215959384
    羽扇烯酮 CFN99681 1617-70-5 20mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Buenos Aires (Argentina)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Osmania University (India)
  • Chiang Mai University (Thailand)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Indian Institute of Science (India)
  • Universidade da Beira Interior (Germany)
  • Universidade Católica Portuguesa (Portugal)
  • University of Queensland (Australia)
  • Semmelweis Unicersity (Hungary)
  • University of Vienna (Austria)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Complutense University of Madrid (Spain)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • AMB Express2020. 10(1):126.
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • LWT2021, 147:111620.
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Appl. Sci.2020, 10(23), 8729
  • Asian J Beauty Cosmetol2020, 18(3): 265-272.
  • J Sci Food Agric.2018, 98(3):1153-1161
  • J Agric Food Chem.2018, 66(1):351-358
  • Molecules.2022, 27(7):2093.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Free Radic Biol Med.2017, 112:191-199
  • Toxicol In Vitro.2022, 81:105346.
  • Sci Rep.2017, 7:467-479
  • Sci Rep.2019, 9:12132
  • Inflammation.2020, 43(5):1716-1728.
  • Anal Biochem.2019, 569:10-15
  • Plant Cell, Tissue and Organ Culture (PCTOC)2020, 143, 45-60(2020)
  • Chemistry of Natural Compounds2018, 54(3):572-576
  • Mediators Inflamm. 2016, 2016:6189590
  • J Biosci.2020, 45:46.
  • Applied Biological Chem. 2020, 26(63).
  • Chem Biol Interact.2016, 258:59-68
  • Eur J Pharmacol.2021, 906:174220.
  • ...
  • 生物活性
    Description: Lupenone and lupeol inhibit protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 13.7 ± 2.1 and 5.6 ± 0.9 uM, respectively, they are non−competitive inhibitors of PTP1B, and PTP1B appears to be an attractive target for the development of new drugs for type 2 diabetes and obesity. Lupenone stimulates melanogenesis by increasing the tyrosinase enzyme expression via mitogen-activated protein kinase phosphorylated extracellular signal-regulated kinases 1 and 2 phosphorylation inhibition. A 1 : 4 mixture of Lupenone and caryophyllene oxide shows trypanocidal activity.
    Targets: PPAR | ERK | MAPK | Antifection | PTP1B
    In vitro:
    Phytother Res. 2013 May;27(5):761-6.
    Lupenone isolated from Adenophora triphylla var. japonica extract inhibits adipogenic differentiation through the downregulation of PPARγ in 3T3-L1 cells.[Pubmed: 22848028]
    Adenophora triphylla var. japonica (Campanulaceae) is known to have anti-inflammatory and anti-tussive effects. Dysfunction of adipocytes and adipose tissue in obesity is related to various inflammatory cytokines or adipokines.
    METHODS AND RESULTS:
    In this study, we investigated whether lupenone isolated from A. triphylla var. japonica extract inhibits adipocyte differentiation and expression of adipogenic marker genes in 3T3-L1 preadipocytes. We demonstrated that lupenone resulted in a significant reduction in lipid accumulation and expression of adipogenic marker genes in a dose-dependent manner. In addition, lupenone decreased the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) induced by troglitazone, and we also demonstrated that lupenone suppressed the PPARγ and CCAAT-enhancer-binding protein α (C/EBPα) protein levels.
    CONCLUSIONS:
    These findings demonstrated that lupenone isolated from A. triphylla var. japonica extract effectively inhibited adipocyte differentiation through downregulation of related transcription factor, particularly the PPARγ gene.
    Evid Based Complement Alternat Med. 2013;2013:435398.
    Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi.[Pubmed: 23762135]
    The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4  μ g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg(-1)·day(-1).
    Biomed Pharmacother . 2018 Jul;103:198-203.
    Beneficial health effects of lupenone triterpene: A review[Pubmed: 29653365]
    Abstract There are a large number of new structure compounds with good pharmacological activity in the natural plants, can be applied to the treatment of human diseases. Finding active ingredients from the plants is one of the important ways to develop new drugs. Triterpenes are widespread in plants, and lupenone belongs to lupane type triterpenoids. Lupenone is very common natural ingredient distributed in multi-family plants including Asteraceae, Balanophoraceae, Cactaceae, Iridaceae, Musaceae, Urticaceae, Leguminosae, Bombacaceae, etc., but its distribution has no regular. The consumption of lupenone in vegetarian diet is high in human life. Pharmacological screening of lupenone revealed various pharmacological activities including anti-inflammatory, anti-virus, anti-diabetes, anti-cancer, improving Chagas disease without major toxicity. Based on these important pharmacological activities, this review provides detailed account of pre-clinical studies conducted to determine the utility of lupenone as a therapeutic and chemopreventive agent for the treatment of various diseases. Keywords: Chagas disease; Diabetes; Inflammation; Lupenone; Tumor; Virus.
    In vivo:
    Mol Divers . 2020 Feb;24(1):21-30.
    Lupenone is a good anti-inflammatory compound based on the network pharmacology[Pubmed: 30796639]
    Abstract The dried rhizome of Musa basjoo Sieb. et Zucc. is Rhizoma Musae. It has been used to treat diabetes in Miao medicine in China. Lupenone was isolated from Rhizoma Musae and has good anti-diabetic activity. Its mechanism of action is unclear. Diabetes is a chronic low-level systemic inflammatory disease, and lupenone has anti-inflammatory activity, but the underlying mechanism is not fully elucidated. In this study, we aimed to construct the drug-target biologic network and predict the anti-inflammatory mechanism of lupenone. The network-based pharmacologic analysis platform was used to identify the target proteins related to inflammation. Furthermore, the effects of lupenone on acute, subacute and diabetic pancreatic inflammation were evaluated. The "component-target-disease" network was constructed using Cytoscape. Lupenone could regulate transcription factor p65, NF-kappa-B inhibitor alpha, transcription factor AP-1, NF-kappa-B essential modulator, nuclear factor NF-kappa-B p105 subunit, epidermal growth factor receptor, hypoxia-inducible factor 1-alpha and other proteins related to the PI3K-Akt, Toll-like receptor and NF-kappa B signaling pathways. In addition, lupenone significantly decreased acute and subacute inflammation in mice as well as the IL-1β and IFN-γ levels in the pancreas of diabetic rats. The above results provide strong support for studying the molecular mechanism of lupenone in the treatment of diabetes from the perspective of anti-inflammation. Keywords: Diabetes; Inflammation; Lupenone; Network pharmacology; Pancreas; Target.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3546 mL 11.773 mL 23.546 mL 47.0921 mL 58.8651 mL
    5 mM 0.4709 mL 2.3546 mL 4.7092 mL 9.4184 mL 11.773 mL
    10 mM 0.2355 mL 1.1773 mL 2.3546 mL 4.7092 mL 5.8865 mL
    50 mM 0.0471 mL 0.2355 mL 0.4709 mL 0.9418 mL 1.1773 mL
    100 mM 0.0235 mL 0.1177 mL 0.2355 mL 0.4709 mL 0.5887 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    羽扇-20(29)-烯-3bate,23-二醇; Lup-20(29)-ene-3bate,23-diol CFN96184 163060-07-9 C30H50O2 = 442.7 5mg QQ客服:215959384
    Lupeolic acid; Lupeolic acid CFN96255 87355-32-6 C30H48O3 = 456.7 5mg QQ客服:3257982914
    羽扇豆醇 3-乙酸酯 ; Lupeol acetate CFN96583 1617-68-1 C32H52O2 = 468.77 10mg QQ客服:1413575084
    咖啡酸羽扇豆醇酯; Lupeol caffeate CFN99057 103917-26-6 C39H56O4 = 588.9 5mg QQ客服:2159513211
    2alpha-羟基羽扇豆醇; Lup-20(29)-ene-2alpha,3beta-diol CFN97717 61448-03-1 C30H50O2 = 442.73 5mg QQ客服:2159513211
    算盘子二醇; Glochidiol CFN97128 6610-56-6 C30H50O2 = 442.7 5mg QQ客服:3257982914
    3-表算盘子二醇; 3-Epiglochidiol CFN98360 29028-10-2 C30H50O2 = 442.7 5mg QQ客服:3257982914
    3-表算盘子二醇二乙酸酯; 3-Epiglochidiol diacetate CFN97122 6587-37-7 C34H54O4 = 526.8 5mg QQ客服:2159513211
    11β-羟基羽扇豆醇; 11beta-Hydroxylupeol CFN89288 49776-92-3 C30H50O2 = 442.72 5mg QQ客服:3257982914
    Adiantulupanone; Adiantulupanone CFN89066 51511-05-8 C29H48O = 412.70 5mg QQ客服:2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产