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  • 芹糖甘草苷

    Liquiritin apioside

    芹糖甘草苷
    产品编号 CFN90707
    CAS编号 199796-12-8
    分子式 = 分子量 C26H30O13 = 550.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Glycyrrhiza uralensis Fisch
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    芹糖甘草苷 CFN90707 199796-12-8 10mg QQ客服:1413575084
    芹糖甘草苷 CFN90707 199796-12-8 20mg QQ客服:1413575084
    芹糖甘草苷 CFN90707 199796-12-8 50mg QQ客服:1413575084
    芹糖甘草苷 CFN90707 199796-12-8 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Eastern Finland (Finland)
  • Complutense University of Madrid (Spain)
  • Universidade da Beira Interior (Germany)
  • Tokyo Woman's Christian University (Japan)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Bonn (Germany)
  • University of Otago (New Zealand)
  • Universiti Sains Malaysia (Malaysia)
  • Hamdard University (India)
  • Shanghai University of TCM (China)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Yale University (USA)
  • University Medical Center Mainz (Germany)
  • Universidad Veracuzana (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biomed Pharmacother.2021, 144:112300.
  • Int J Mol Sci.2019, 20(16):E4015
  • Toxicol Mech Methods.2021, 1-12.
  • Front Pharmacol.2020, 11:683.
  • Elife.2021, 10:e68058.
  • Acta Chromatographica2021, 00960.
  • Antioxidants (Basel).2020, 9(6):466.
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Int J Mol Sci.2017, 18(12)
  • Biomed Pharmacother.2019, 111:262-269
  • J Nat Prod.2017, 80(4):854-863
  • Int J Oncol.2019, 55(1):320-330
  • Tissue Cell.2022, 75:101728.
  • Front Pharmacol.2020, 11:251.
  • Int J Mol Sci.2021, 22(17):9400.
  • Int J Pharmacol2020, 16:1-9
  • Exp Parasitol.2017, 183:160-166
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • Chem Biol Interact.2018, 283:59-74
  • Analytical Letters 2021, 54(4).
  • Int J Biol Macromol.2018, 112:1093-1103
  • Oncotarget.2016, 8(51):88386-88400
  • ...
  • 生物活性
    Description: Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as protective agent against epithelial injury in COPD.
    Targets: TNF-α | TGF-β/Smad
    In vivo:
    Fundam Clin Pharmacol. 2012 Aug;26(4):473-83.
    Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury. [Pubmed: 21631586]
    Cigarette smoking is associated with an increased incidence of chronic obstructive pulmonary disease (COPD).
    METHODS AND RESULTS:
    In this study, we hypothesized that liquiritin apioside (LA), a main flavonoid component from Glycyrrhiza uralensis, had antioxidant properties by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress. A549 cells were treated with cigarette smoke extract (CSE) and/or LA. ICR mice were exposed to cigarette smoke (CS) for four days with increasing exposure time for up to 6 h per day to elicit epithelial cells injury. One hour before smoke exposure, mice were treated with LA by gavage; 18 h after the last CS exposure all examinations were performed. Treatment with LA concentration-dependently prevented CSE-induced cytotoxicity, increase of TGF-β and TNF-α mRNA expression, depletion of GSH and apoptosis in A549 cells. LA at doses 3, 10 and 30 mg/kg dose-dependently inhibited pulmonary neutrophil and macrophage inflammation. Lung sections of the CS-exposed LA treated mice showed an apparently reduced pulmonary inflammation and a significant inhibitory effect on mucus containing goblet cells in the large airways. Furthermore, the CS-induced pulmonary release of TGF-β, TNF-α and myeloperoxidase activity was reduced, and superoxide dismutase activity was enhanced.
    CONCLUSIONS:
    These results indicate that protective roles of LA on CS-induced the lung epithelial cell injury are mediated by inhibiting TGF-β and TNF-α expression and increasing anti-oxidative levels of GSH, suggesting that LA might be effective as protective agent against epithelial injury in COPD.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8165 mL 9.0827 mL 18.1653 mL 36.3306 mL 45.4133 mL
    5 mM 0.3633 mL 1.8165 mL 3.6331 mL 7.2661 mL 9.0827 mL
    10 mM 0.1817 mL 0.9083 mL 1.8165 mL 3.6331 mL 4.5413 mL
    50 mM 0.0363 mL 0.1817 mL 0.3633 mL 0.7266 mL 0.9083 mL
    100 mM 0.0182 mL 0.0908 mL 0.1817 mL 0.3633 mL 0.4541 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柚皮素-7-O-龙胆二糖苷; Naringenin 7-O-gentiobioside CFN95435 104154-33-8 C27H32O15 = 596.5 5mg QQ客服:1413575084
    5,6,7,4'-四羟基黄酮 6,7-二葡萄糖苷; 5,6,7,4'-Tetrahydroxyflavanone 6,7-diglucoside CFN92520 501434-65-7 C27H32O16 = 612.5 5mg QQ客服:2159513211
    异樱花苷; Isosakuranin CFN92809 491-69-0 C22H24O10 = 448.1 10mg QQ客服:2159513211
    枸橘苷; Poncirin CFN90448 14941-08-3 C28H34O14 = 594.56 20mg QQ客服:2932563308
    香风草甙; Didymin CFN92363 14259-47-3 C28H34O14 = 594.6 20mg QQ客服:215959384
    半皮桉苷; Hemiphloin CFN91855 71963-94-5 C21H22O10 = 434.4 5mg QQ客服:215959384
    异柚葡糖苷; Isohemiphloin CFN98602 3682-02-8 C21H22O10 = 434.4 5mg QQ客服:2159513211
    杜鹃素 7-O-葡萄糖苷; Farrerol 7-O-glucoside CFN96281 885044-12-2 C23H26O10 = 462.5 5mg QQ客服:1413575084
    Flavaprin; Flavaprin CFN98900 53846-49-4 C26H30O10 = 502.5 5mg QQ客服:2932563308
    甘草苷; Liquiritin CFN99154 551-15-5 C21H22O9 = 418.39 20mg QQ客服:2159513211

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