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  • 中药标准品生产商,产品定制服务
  • 香风草甙


    产品编号 CFN92363
    CAS编号 14259-47-3
    分子式 = 分子量 C28H34O14 = 594.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Clinopodium chinense
    产品名称 产品编号 CAS编号 包装 QQ客服
    香风草甙 CFN92363 14259-47-3 10mg QQ客服:3257982914
    香风草甙 CFN92363 14259-47-3 20mg QQ客服:3257982914
    香风草甙 CFN92363 14259-47-3 50mg QQ客服:3257982914
    香风草甙 CFN92363 14259-47-3 100mg QQ客服:3257982914
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • University of Limpopo (South Africa)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Periyar University (India)
  • Georgia Institute of Technology (USA)
  • Chulalongkorn University (Thailand)
  • Complutense University of Madrid (Spain)
  • Texas A&M University (USA)
  • Tohoku University (Japan)
  • University of Otago (New Zealand)
  • University of Wollongong (Australia)
  • University of Dicle (Turkey)
  • Universidad Miguel Hernández (Spain)
  • Srinakharinwirot University (Thailand)
  • University of Wisconsin-Madison (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules2022, 27(12):3903.
  • Int J Mol Med.2015, 35(5):1237-45
  • Nutrients2022, 14(3),695.
  • Antioxidants (Basel).2021, 10(11):1831.
  • J Agric Food Chem.2016, 64(35):6783-90
  • Int J Pharm.2022, 618:121636.
  • Phytomedicine.2019, 62:152962
  • Korean Herb. Med. Inf.2020, 8(2):243-254.
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Int J Mol Sci.2019, 21(1):E265
  • Int J Mol Med.2019, 43(6):2516-2522
  • RSC Advances2017, 86
  • Antioxidants (Basel).2020, 9(6):466.
  • Metabolites.2020, 10(11):440.
  • New Zealand J. Forestry Sci.2014, 44:17
  • Cell Chem Biol.2019, 26(1):27-34
  • Toxicol Appl Pharmacol.2021, 427:115668.
  • Talanta.2022, 249:123645.
  • Int J Mol Sci.2020, 21(7):2530.
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  • ...
  • 生物活性
    Description: Didymin is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture, it induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma. Didymin possesses antioxidant, anti-inflammation and anti-cancer properties.
    Targets: ROS | JNK | Caspase | p53 | PI3K | Akt | CDK | p21
    In vitro:
    Cells Tissues Organs. 2014;199(2-3):184-200.
    Neuroprotective effect of didymin on hydrogen peroxide-induced injury in the neuronal membrane system.[Pubmed: 25412833]

    In this study, the flavonoid didymin was administered in vitro in neuronal cells after hydrogen peroxide (H2O2)-induced injury (neurorescue) in order to investigate the effects of this natural molecule on cell damage in a neuronal membrane system. The results showed the effects of didymin in neuronal cells by using a polycaprolactone biodegradable membrane system as an in vitro model. Two major findings are presented in this study: first is the antioxidant property of didymin and, second, for the first time we provide evidence concerning its ability to rescue neuronal cells from oxidative damage. Didymin showed radical scavenging activities and it protected the neuronal cells against H2O2-induced neurotoxicity. Didymin increased cell viability, decreased intracellular reactive oxygen species generation, stimulated superoxide dismutase, catalase and glutathione peroxidase activity in neuronal cells which were previously insulted with H2O2. In addition, didymin strikingly inhibited H2O2-induced mitochondrial dysfunctions in terms of reduction of mitochondria membrane potential and the activation of cleaved caspase-3, and also decreased dramatically the H2O2-induced phosphorylation of c-Jun N-terminal kinase. Therefore, this molecule is capable of inducing recovery from oxidative damage, and promoting and/or restoring normal cellular conditions. Moreover, the mechanism underlying the protective effects of didymin in H2O2-injured neuronal cells might be related to the activation of antioxidant defense enzymes as well as to the inhibition of apoptotic features, such as p-JNK and caspase-3 activation.
    These data suggest that didymin may be a potential therapeutic molecule for the treatment of neurodegenerative disorders associated with oxidative stress.
    Lung Cancer. 2010 Jun;68(3):366-74.
    Didymin, a dietary flavonoid glycoside from citrus fruits, induces Fas-mediated apoptotic pathway in human non-small-cell lung cancer cells in vitro and in vivo.[Pubmed: 19733932]
    Epidemiological studies provided evidence that the high dietary intake of flavonoids with fruits and vegetables could be associated with lower cancer prevalence in humans. Didymin, a dietary flavonoid glycoside from citrus fruits, possesses antioxidant properties.
    This study first investigates the anticancer effect of Didymin in human non-small-cell lung cancer A549 and H460 cells. To identity the anticancer mechanism of Didymin, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor, and Fas ligand. The results showed that Didymin-induced apoptosis of A549 and H460 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of Didymin-mediated apoptosis of A549 and H460 cells. Importantly, a novel chemotherapeutic agent for the treatment of non-small-cell lung cancer, and is supported by animal studies which have shown Didymin delay the tumor growth in nude mice.
    Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of Didymin in A549 and H460 cells.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6818 mL 8.409 mL 16.818 mL 33.6361 mL 42.0451 mL
    5 mM 0.3364 mL 1.6818 mL 3.3636 mL 6.7272 mL 8.409 mL
    10 mM 0.1682 mL 0.8409 mL 1.6818 mL 3.3636 mL 4.2045 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6727 mL 0.8409 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    柚皮苷 4'-葡萄糖苷; Naringin 4'-glucoside CFN95014 17257-21-5 C33H42O19 = 742.7 5mg QQ客服:2159513211
    Bergamjuicin; Bergamjuicin CFN95422 2376307-20-7 C39H50O23 = 886.8 5mg QQ客服:2159513211
    柚皮芸香苷; Narirutin CFN99543 14259-46-2 C27H32O14 = 580.53 20mg QQ客服:1413575084
    芸香柚皮苷 4'-葡萄糖苷; Narirutin 4'-glucoside CFN95421 17257-22-6 C33H42O19 = 742.7 10mg QQ客服:1413575084
    Pyrroside B; Pyrroside B CFN96142 116271-35-3 C26H30O14 = 566.5 5mg QQ客服:3257982914
    柚皮素-7-O-龙胆二糖苷; Naringenin 7-O-gentiobioside CFN95435 104154-33-8 C27H32O15 = 596.5 5mg QQ客服:2932563308
    5,6,7,4'-四羟基黄酮 6,7-二葡萄糖苷; 5,6,7,4'-Tetrahydroxyflavanone 6,7-diglucoside CFN92520 501434-65-7 C27H32O16 = 612.5 5mg QQ客服:215959384
    异樱花苷; Isosakuranin CFN92809 491-69-0 C22H24O10 = 448.1 10mg QQ客服:1148253675
    枸橘苷; Poncirin CFN90448 14941-08-3 C28H34O14 = 594.56 20mg QQ客服:2932563308
    香风草甙; Didymin CFN92363 14259-47-3 C28H34O14 = 594.6 20mg QQ客服:215959384





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