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    • 反-甲基异丁香酚

    trans-Methylisoeugenol

    反-甲基异丁香酚
    		产品编号 CFN96259
    CAS编号 6379-72-2
    分子式 = 分子量 C11H14O2 = 178.2
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Phenylpropanoids
    植物来源 The roots of Atractylodes macrocephala
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    反-甲基异丁香酚 CFN96259 6379-72-2 1mg QQ客服：2056216494
    反-甲基异丁香酚 CFN96259 6379-72-2 5mg QQ客服：2056216494
    反-甲基异丁香酚 CFN96259 6379-72-2 10mg QQ客服：2056216494
    反-甲基异丁香酚 CFN96259 6379-72-2 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Harvard University (USA)
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  • Mendel University in Brno (Czech Republic)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Pharmacol Sci.2021, 147(2):184-191.
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Environ Toxicol.2019, 34(4):513-520.
  • bioRxiv2021, 458409.
  • Journal of Chromatography A2020, 460942
  • Int J Mol Sci.2020, 21(9):3239.
  • International. J. of Food Properties 2017, 20:S131-S140
  • Oncotarget.2017, 9(3):4161-4172
  • BMC Plant Biol.2021, 21(1):60.
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Front Cell Infect Microbiol.2018, 8:292
  • Trop J Pharm Res.2023, 22(3):283-288.
  • Int J Mol Sci.2022, 23(5):2796.
  • Evid Based Complement Alternat Med.2020, 2020:9416962.
  • Evid Based Complement Alternat Med.2022, 9767292,2.
  • Agronomy 2021, 11(3),502.
  • J Cell Mol Med . 2023, jcmm.17954.
  • JEJU National University2022, 10478.
  • Appl. Sci.2020, 10(23), 8729
  • Nutrients.2019, 12(1)
  • Phytother Res.2022, 35844057.
  • Int J Mol Sci.2017, 18(5)
  • ...
    • 生物活性
    Description: (E)-Methyl isoeugenol (trans-Methylisoeugenol) is a natural food flavour, it also has anxiolytic and antidepressant like properties. Eugenol methyl ether(trans-Methylisoeugenol) can cause moderate reversible inhibition of glutathione S-transferases (GSTs)(I25 ranged from 0.2 to 5.4 mM for human GSTs and from 0.4 to 4.9 mM for rat GSTs).The use of isoeugenol methyl ether(trans-Methylisoeugenol) is described as an agent to inhibit and/or prevent the growth of and/or to destroy micro-organisms causing bad breath and/or to combat bad breath.
    Targets: 5-HT Receptor
    In vivo:
    PAT-WO2006032664
    Use of isoeugenol methyl ester as an agent against bad breath[Reference: WebLink]

    METHODS AND RESULTS:
    The use of isoeugenol methyl ether(trans-Methylisoeugenol)is described as an agent (i) to inhibit and/or prevent the growth of and/or to destroy micro-organisms causing bad breath and/or (ii) to combat bad breath.
    Food Funct. 2014 Aug;5(8):1819-28.
    Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol.[Pubmed: 24920211 ]
    (E)-methyl isoeugenol (MIE, trans-Methylisoeugenol) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food additive, the application of MIE for treating mood disorders appears to be globally attractive.
    METHODS AND RESULTS:
    Hence, we sought to evaluate general pharmacological activities, anticonvulsant, anxiolytic and antidepressant effects and the possible mechanisms of MIE actions. MIE at 250 and 500 mg kg(-1) potentiated the hypnotic effect of sodium pentobarbital. However, MIE did not protect against PTZ-induced convulsion. Except for MIE at 500 mg kg(-1), parameters evaluated in the LDB, EPM and OF demonstrated an anxiolytic like property of MIE. This effect was blocked by WAY100635 pretreatment. MIE at 500 mg kg(-1) elicited a reduction in locomotor activity of the mice in the OF. Anti-immobility effect of MIE 250 mg kg(-1) in the FST suggested an antidepressive like property. Unlike AMPT, pretreatment with PCPA reversed the antidepressant like effect of MIE.
    CONCLUSIONS:
    Our findings demonstrated anxiolytic and antidepressant like properties of (E)-methyl isoeugenol and suggested the participation of serotonergic pathways.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.6117 mL 28.0584 mL 56.1167 mL 112.2334 mL 140.2918 mL
    5 mM 1.1223 mL 5.6117 mL 11.2233 mL 22.4467 mL 28.0584 mL
    10 mM 0.5612 mL 2.8058 mL 5.6117 mL 11.2233 mL 14.0292 mL
    50 mM 0.1122 mL 0.5612 mL 1.1223 mL 2.2447 mL 2.8058 mL
    100 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1223 mL 1.4029 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    茴香脑; Anethole CFN98550 104-46-1 C10H12O = 148.2 20mg QQ客服：1413575084
    4-烯丙基儿茶酚; 4-(2-丙烯基)-1,2-苯二醇; 4-烯丙基-1,2-苯二醇; 4-Allylpyrocatechol CFN99226 1126-61-0 C9H10O2 = 150.2 20mg QQ客服：215959384
    丁香酚; Eugenol CFN99175 97-53-0 C10H12O2 = 164.20 20mg QQ客服：1413575084
    甲基丁香酚, 甲基丁子香酚 ; Methyleugenol CFN96177 93-15-2 C11H14O2 = 178.2 20mg QQ客服：2056216494
    水杨梅苷; Geoside CFN95233 585-90-0 C21H30O11 = 458.5 5mg QQ客服：3257982914
    顺式-甲基异丁香油酚; cis-Methylisoeugenol CFN97095 6380-24-1 C11H14O2 = 178.2 5mg QQ客服：1413575084
    反-甲基异丁香酚; trans-Methylisoeugenol CFN96259 6379-72-2 C11H14O2 = 178.2 5mg QQ客服：1413575084
    3,4-二甲氧基桂皮醇; 3,4-Dimethoxycinnamyl alcohol CFN96231 40918-90-9 C11H14O3 = 194.2 5mg QQ客服：2056216494
    4-丙基-2,6-二甲氧基苯酚; Syringylpropane CFN92632 6766-82-1 C11H16O3 = 196.2 5mg QQ客服：2056216494
    2,6-二甲氧基-4-(1E)-1-丙烯基苯基 beta-D-吡喃葡萄糖苷; Acantrifoside E CFN96354 645414-25-1 C17H24O8 = 356.4 5mg QQ客服：215959384

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