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  • 对羟基肉桂酸

    p-Hydroxy-cinnamic acid

    产品编号 CFN98179
    CAS编号 7400-08-0
    分子式 = 分子量 C9H8O3 = 164.16
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The barks of Cinnamomum cassia Presl
    产品名称 产品编号 CAS编号 包装 QQ客服
    对羟基肉桂酸 CFN98179 7400-08-0 10mg QQ客服:3257982914
    对羟基肉桂酸 CFN98179 7400-08-0 20mg QQ客服:3257982914
    对羟基肉桂酸 CFN98179 7400-08-0 50mg QQ客服:3257982914
    对羟基肉桂酸 CFN98179 7400-08-0 100mg QQ客服:3257982914
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • 生物活性
    Description: p-Hydroxy-cinnamic acid may have in vitro antimalarial activity. p-Hydroxycinnamic acid and β-cryptoxanthin have anti-osteoporotic properties in vivo, they can antagonize NF-κB activation in MC3T3 preosteoblastic cells。
    Targets: NF-kB | Antifection
    In vitro:
    Parasitol Res. 2012 Feb;110(2):539-44.
    Antimalarial drug interactions of compounds isolated from Kigelia africana (Bignoniaceae) and their synergism with artemether, against the multidrug-resistant W2mef Plasmodium falciparum strain.[Pubmed: 21814840]
    For decades, drug resistance has been the major obstacle in the fight against malaria, and the search for new drugs together with the combination therapy constitutes the major approach in responding to this situation.
    The present study aims at assessing the in vitro antimalarial activity of four compounds isolated from Kigelia africana stem bark (atranorin - KAE1, specicoside - KAE7, 2β,3β,19α-trihydroxy-urs-12-20-en-28-oic acid - KAE3, and p-hydroxy-cinnamic acid - KAE10) and their drug interactions among themselves and their combination effects with quinine and artemether. The antiplasmodial activity and drug interactions were evaluated against the multidrug-resistant W2mef strain of Plasmodium falciparum using the parasite lactate dehydrogenase assay. Three of the four compounds tested were significantly active against W2mef: specicoside (IC(50) = 1.02 ± 0.17 μM), 2β,3β,19α-trihydroxy-urs-12-en-28-oic acid (IC(50) = 1.86 ± 0.15 μM) and atranorin (IC(50) = 1.78 ± 0.18 μM), whereas p-hydroxy-cinnamic acid showed a weak activity (IC(50) = 12.89 ± 0.87 μM). A slight synergistic effect was observed between atranorin and 2β,3β,19α-trihydroxy-urs-12-en-28-oic acid (Combination index, CI = 0.82) whereas the interaction between specicoside and p-hydroxy-cinnamic acid were instead antagonistic (CI = 2.67).
    All the three compounds showed synergistic effects with artemether, unlike the slight antagonistic interactions of atranorin and 2β,3β,19α-trihydroxy-urs-12-en-28-oic acid in combination with quinine. K. africana compounds are therefore likely to serve as leads in the development of new partner drugs in artemether-based combination therapy.
    Nat Prod Commun. 2012 Oct;7(10):1351-2.
    Thymofolinoates A and B, new cinnamic acid derivatives from Euphorbia thymifolia.[Pubmed: 23157007]
    Two new cinnamic acid derivatives, thymofolinoates A (1) and B (2) have been isolated from the chloroform soluble fraction of Euphorbia thymifolia and their structures assigned from 1H and 13C NMR spectra, DEPT and by 2 D COSY, HMQCand H MBC experiments. In addition, p-hydroxy-cinnamic acid(3), 5-hydroxy-6,7,8,4'-tetramethoxy flavone (4), and 5-hydroxy-3',4',6,7,8-pentamethoxy flavone (5) have also been isolated for the first time from this species.
    In vivo:
    Mol Med Rep. 2009 Jul-Aug;2(4):641-4.
    The bone anabolic carotenoids p-hydroxycinnamic acid and β-cryptoxanthin antagonize NF-κB activation in MC3T3 preosteoblasts.[Pubmed: 21475879]
    The carotene p-hydroxycinnamic acid and the xanthophyll β-cryptoxanthin are members of the carotenoid family of plant-derived pigments, which are endowed with anti-osteoporotic properties in vivo. p-Hydroxycinnamic acid and β-cryptoxanthin have been demonstrated to stimulate osteoblastic bone formation while simultaneously repressing osteoclastic bone resorption in vitro. However, their mechanisms of action remain poorly elucidated. It is well established that the NF-;kgr;B signal transduction pathway plays a critical role in osteoclast differentiation. Moreover, we recently demonstrated that NF-κB activity potently antagonizes osteoblastic differentiation and mineralization in vitro.
    In this study, we used transient transfection assays of a NF-κB luciferase reporter to demonstrate that p-hydroxycinnamic acid and β-cryptoxanthin antagonize NF-κB activation in MC3T3 preosteoblastic cells.
    The data obtained suggest that NF-κB may be a common molecular target by which several bone active agents, including carotenoids, promote osteoblastic bone formation.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.0916 mL 30.4581 mL 60.9162 mL 121.8324 mL 152.2904 mL
    5 mM 1.2183 mL 6.0916 mL 12.1832 mL 24.3665 mL 30.4581 mL
    10 mM 0.6092 mL 3.0458 mL 6.0916 mL 12.1832 mL 15.229 mL
    50 mM 0.1218 mL 0.6092 mL 1.2183 mL 2.4366 mL 3.0458 mL
    100 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.2183 mL 1.5229 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4-甲氧基肉桂酸; 4-Methoxycinnamic acid CFN98191 830-09-1 C10H10O3 = 178.18 20mg QQ客服:1413575084
    顺式-香豆酸-4-葡萄糖苷; 4-O-beta-Glucopyranosyl-cis-coumaric acid CFN93803 117405-48-8 C15H18O8 = 326.29 5mg QQ客服:2932563308
    4-羟基肉桂酸甲酯; Methyl 4-hydroxycinnamate CFN96113 19367-38-5 C10H10O3 = 178.2 20mg QQ客服:3257982914
    对香豆酸乙酯; p-Coumaric acid ethyl ester CFN97218 7362-39-2 C11H12O3 = 192.2 20mg QQ客服:2932563308
    对甲氧基肉桂酸乙酯; Ethyl 4-methoxycinnamate CFN98180 24393-56-4 C12H14O3 = 206.24 20mg QQ客服:2932563308
    3-(4-甲氧基苯基)丙酸甲酯; Methyl 3-(4-methoxyphenyl)propanoate CFN96152 15823-04-8 C11H14O3 = 194.2 5mg QQ客服:3257982914
    Ethyl 3-(4-methoxyphenyl)propanoate; Ethyl 3-(4-methoxyphenyl)propanoate CFN96138 22767-72-2 C12H16O3 = 208.3 5mg QQ客服:1413575084
    4-羟基苯基乳酸甲酯; Methyl p-hydroxyphenyllactate CFN96379 51095-47-7 C10H12O4 = 196.2 5mg QQ客服:2159513211
    3-(4-羟基苯基)乳酸乙酯; Ethyl p-hydroxyphenyllactate CFN96363 62517-34-4 C11H14O4 = 210.2 5mg QQ客服:2159513211
    2,3-二羟基-3-(4-羟基苯基)丙酸; 2,3-dihydroxy-3-(4-hydroxyphenyl)propanoic acid CFN99018 100201-57-8 C9H10O5 = 198.2 5mg QQ客服:3257982914





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