d-Laserpitin

	产品编号	CFN92710
	CAS编号	134002-17-8
	分子式 = 分子量	C₁₉H₂₀O₆ = 344.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The herbs of Seseli gummiferum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
d-Laserpitin	CFN92710	134002-17-8	1mg	QQ客服：215959384
d-Laserpitin	CFN92710	134002-17-8	5mg	QQ客服：215959384
d-Laserpitin	CFN92710	134002-17-8	10mg	QQ客服：215959384
d-Laserpitin	CFN92710	134002-17-8	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Reference standards.

In vitro:

J Chromatogr A. 2013 Oct 4;1310:66-73.

Application of stepwise gradients in counter-current chromatography: a rapid and economical strategy for the one-step separation of eight coumarins from Seseli resinosum.[Pubmed: 23992840]

The targeted purification of compounds with a broad polarity range from traditional medicinal plants is a big challenge for counter-current chromatography (CCC). Gradient elution was introduced in CCC to address this problem. However, once a suitable solvent system is selected, the separation process requires optimization of operational parameters.
METHODS AND RESULTS:
The present study was conducted to optimize various operational parameters to integrate the flow rate and solvent gradients for the rapid isolation of eight coumarins from Seseli resinosum in a single run. An increase in the system temperature from 15°C to 35°C increased the stationary phase retention and solubility of the sample, whereas the operation time and viscosity of the system were decreased. The high purity of each compound was ensured by collecting the fractions from the main peaks while all the shoulder peaks were mixed and separated under the same conditions with semi-preparative CCC. GC-FID was used to analyze the components of each phase, which was prepared without presaturation to save the time and solvent consumption. Finally, eight coumarins were purified, including (1) d-laserpitin, (2) (3'S,4'S)-3'-angeloyloxy-4'-hydroxy-3',4'-dihydroseselin, (3) (+)-samidin, (4) (3'S,4'S)-3'-acetoxy-4'-angeloyloxy-3',4'-dihydroseselin, (5) deltoin (6), calipteryxin, (7) (3'S,4'S)-3',4'-disenecioyloxy-3',4'-dihydroseselin, and (8) (-)-anomalin.
CONCLUSIONS:
The present technique has successfully accomplished the goal of one-step separation of these compounds with high purity and recovery in an economic and time efficient manner.

In vivo:

Z Naturforsch C. 2009 Jan-Feb;64(1-2):56-62.

Anti-inflammatory and antinociceptive activity of coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae).[Pubmed: 19323267]

n-Hexane and ethyl acetate extracts as well as coumarin derivatives obtained from the n-hexane extract of the aerial parts of Seseli gummiferum Pall. ex Sm. subsp. corymbosum (Boiss. & Heldr.) P.H. Davis (Apiaceae) were evaluated in vivo for their anti-inflammatory and antinociceptive activities.
METHODS AND RESULTS:
The n-hexane and ethyl acetate extracts of the species were shown to possess significant inhibitory activity against the carrageenan-induced hind paw edema and p-benzoquinone-induced writhing models in mice. Among the isolated coumarin derivatives; (-)-(3'S,4'S)-3'-acetoxy-4'-isovaleryloxy-3',4'-dihydroseselin (1), (-)-(3'S,4'S)-3'-acetoxy-4'-angeloyloxy-3',4'-dihydroseselin (2), (+)-(3'S,4'S)-3'-hydroxy-4'-angeloyloxy-3',4'-dihydroseselin (D-laserpitin) (3), (-)-(3'S,4'S)-3'-angeloyloxy-4'-hydroxy-3',4'-dihydroseselin (4), and osthole (5), only the 3'-acetoxy derivatives 1 and 2 were found to possess potent antinociceptive and anti-inflammatory activities, per os, without inducing any apparent acute toxicity as well as gastric damage, while all other compounds and extracts were found to be ineffective in the TPA-induced mouse ear edema model assay.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
顺式凯尔消旋内酯; cis-Khellactone	CFN92799	15645-11-1	C₁₄H₁₄O₅ = 262.3	5mg	QQ客服：1413575084
d-Laserpitin; d-Laserpitin	CFN92710	134002-17-8	C₁₉H₂₀O₆ = 344.4	5mg	QQ客服：1413575084
(+)-白花前胡甲素; (+)-Praeruptorin A	CFN98141	73069-27-9	C₂₂H₂₂O₈ = 414.41	5mg	QQ客服：215959384
白花前胡丁素，(+)-川白芷内酯; Praeruptorin D	CFN98142	73069-28-0	C₂₄H₂₆O₇ = 426.46	5mg	QQ客服：1413575084
白花前胡素E; Praeruptorin E	CFN90449	78478-28-1	C₂₄H₂₈O₇ = 428.47	5mg	QQ客服：3257982914
北美芹素; (+)-Pteryxin	CFN92559	13161-75-6	C₂₁H₂₂O₇ = 386.4	20mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9036 mL	14.518 mL	29.036 mL	58.072 mL	72.59 mL
5 mM	0.5807 mL	2.9036 mL	5.8072 mL	11.6144 mL	14.518 mL
10 mM	0.2904 mL	1.4518 mL	2.9036 mL	5.8072 mL	7.259 mL
50 mM	0.0581 mL	0.2904 mL	0.5807 mL	1.1614 mL	1.4518 mL
100 mM	0.029 mL	0.1452 mL	0.2904 mL	0.5807 mL	0.7259 mL

d-Laserpitin

d-Laserpitin

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