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  • 花椒素

    Xanthoxylin

    花椒素
    产品编号 CFN97465
    CAS编号 90-24-4
    分子式 = 分子量 C10H12O4 = 196.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The roots of Zanthoxylum simulans.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    花椒素 CFN97465 90-24-4 10mg QQ客服:2056216494
    花椒素 CFN97465 90-24-4 20mg QQ客服:2056216494
    花椒素 CFN97465 90-24-4 50mg QQ客服:2056216494
    花椒素 CFN97465 90-24-4 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • John Innes Centre (United Kingdom)
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  • Deutsches Krebsforschungszentrum (Germany)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • University of Zurich (Switzerland)
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  • Stanford University (USA)
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  • Instituto de Investigaciones Agropecuarias (Chile)
  • Utrecht University (Netherlands)
  • Tohoku University (Japan)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Chulalongkorn University (Thailand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. Korean Wood Sci. Technol.2022, 50(5):338-352.
  • J Korean Society of Food Science & Nutrition2021, 50(9): 962-970
  • Pol J Microbiol.2021, 70(1):117-130.
  • Nutrients.2021, 13(8):2901.
  • Saudi Pharm J2020, 10.1016
  • Biochem Biophys Res Commun.2020, 522(4):1052-1058
  • Pharmaceuticals.2022, 15(4), 402.
  • Heliyon.2023, 9:e21652.
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • Phytother Res.2022, 10.1002:ptr.7592.
  • The Journal of Korean Medicine2022, 43(3): 79-93.
  • BMC Plant Biol.2020, 20(1):214.
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Phytomedicine.2019, 59:152785
  • J Ethnopharmacol.2022, 289:115018.
  • Food Chem.2017, 228:301-314
  • Research Square2020, doi: 10.21203.
  • FEBS Lett.2021, 595(20):2608-2615.
  • Nutrients.2020, 12(3):595.
  • Antioxidants.2022, 11(3):592.
  • J Ethnopharmacol.2016, 194:219-227
  • Chemistry of Plant Materials.2016, 33-46
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  • ...
  • 生物活性
    Description: Xanthoxyline has antispasmodic, fungistatic, antinociceptive and antioedematogenic activities. Xanthoxylin has inhibitory effect on blood platelet aggregation; it induces melanogenesis mainly via cAMP-mediated PKA activation, other signaling pathways may also play a role in xanthoxylin-induced melanogenesis.
    Targets: PKA | cAMP | PKC | Antifection
    In vitro:
    Asian Biomed., 2012, 6(3):413-22.
    Effect of xanthoxylin on melanin content and melanogenic protein expression in B16F10 melanoma[Reference: WebLink]
    Reduced production of melanin and decreased or absence of melanocytes leads to various hypopigmentation disorders. Melanin synthesis is regulated by melanogenic proteins such as tyrosinase, tyrosinase-related protein 1 (TRP-1) and tyrosinase-related protein 2 (TRP -2), as well as their transcription factors. This study elucidated the effects of Xanthoxylin on melanin content, dendriticity, melanogenic protein expression and its signal transduction pathways in mouse B16F10 melanoma cells (B16F10 cells).
    METHODS AND RESULTS:
    Melanin production of B16F10 cells was measured by using a melanin content assay. The effect of Xanthoxylin on the dendriticity of B16F10 cells was determined by a melanocyte dendricity assay. RT-PCR was used to investigate the effects of Xanthoxylin on the melanogenic protein expression. We found that Xanthoxylin increased melanin production, number of dendrites, tyrosinase, and microphthalmia-associated transcription factor (MITF) expression in cultured B16F10 cells. In addition, PKA and PKC inhibitor decreased melanin production, tyrosinase, and MITF expression in Xanthoxylin-treated cells. However, Xanthoxylin did not inhibit TRP-1 and TRP-2 expression.
    CONCLUSIONS:
    These results indicated that Xanthoxylin induces melanogenesis mainly via cAMP-mediated PKA activation. Other signaling pathways may also play a role in Xanthoxylin-induced melanogenesis.
    J Pharm Sci. 1995 Apr;84(4):473-5.
    Antispasmodic activity of xanthoxyline derivatives: structure-activity relationships.[Pubmed: 7629739]

    METHODS AND RESULTS:
    The antispasmodic activity of several Xanthoxyline derivatives against acetylcholine-induced contraction of the guinea pig ileum was evaluated in vitro. The acetophenones with two methoxyl groups, mainly in the 3,4 positions, exhibited potent antispasmodic activity. Modification of the hydroxyl group in Xanthoxyline by the introduction of benzoyl, acetyl, or tosyl groups produced inactive compounds, whereas the introduction of benzyl or p-methoxybenzyl groups furnished compounds that were four- to eight-fold more potent than Xanthoxyline. In marked contrast, the introduction of a methyl group gave a compound that caused contractant activity. Modification of the carbonyl group of Xanthoxyline lead to inactive compounds, whereas the condensation of Xanthoxyline with benzaldehydes gave chalkones that were about fivefold more potent than Xanthoxyline. The introduction of benzyl and styrene groups, on the basis of the similarity with papaverine, improves the antispasmodic action of the Xanthoxyline derivates.
    CONCLUSIONS:
    Our results suggest that the methoxyl and carbonyl groups are critical structural points for the antispasmodic activity of Xanthoxyline derivatives. The hydroxyl group improves antispasmodic activity, but is not fundamental to its manifestation.
    Arzneimittelforschung. 1999 Dec;49(12):1039-43.
    In vitro antifungal evaluation and studies on the mode of action of xanthoxyline derivatives.[Pubmed: 10635452]

    METHODS AND RESULTS:
    This study describes the fungistatic effect of xanthoxyline (CAS 90-24-4) and its derivatives against a panel of yeasts, filamentous fungi and dermatophytes, by using the agar dilution method. Results indicated that simple structural modifications led to more potent derivatives, especially in relation with dermatophytes. The most active compound tested (10), which is a benzenesulphonyl derivative, was 12-fold more potent than xanthoxyline itself against Trichophyton rubrum.
    CONCLUSIONS:
    The evaluation of the mode of action with the whole cell Neurospora crassa assay, suggested that some selected compounds may be acting by the inhibition of fungal cell-wall polymers synthesis or assembly.
    In vivo:
    Traditional Chinese Drug Research & Clinical Pharmacology,2000, 11(6):352-3.
    Inhibitory Effect of Xanthoxylin on Blood Platelet Aggregation in Rabbits.[Reference: WebLink]
    Turbidimetry was used to examine the inhibitory effect of Xanthoxyin on adenosine diphosphate (ADP)-, arachidic acid (AA )- and thrombin-induced platelet aggregation in rabbits.
    METHODS AND RESULTS:
    In-vitro experiment showed that Xanthoxyin 0.037,0.l85,0.924,9.240,92.40μmol. L -1 , can significantly inhibit ADP-, AA- and thrombin-induced platelet aggregation. The inhibition rates were 22.4%-70.l%,l5.3%-68.2% and 25.8%-74.6% respectively. In-vivo experiment showed that Xanthoxylin (ig. 5 mg/kg) cand also inhibited ADP-, AA-and throbin-induced platelet aggregations. The inhibition rates were 2l.0%,35.7%,50.9% and 32.7% in ADP-induced group,23.2%,46.3%,52.4% and 4l.6% in AA-induced group, and 26.7%, 44.5%,6l.6% and 54.2% in thrombin-induced group respectively l5,30, 60 and 90 minutes after ig. Xanthoxylin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.0968 mL 25.4842 mL 50.9684 mL 101.9368 mL 127.421 mL
    5 mM 1.0194 mL 5.0968 mL 10.1937 mL 20.3874 mL 25.4842 mL
    10 mM 0.5097 mL 2.5484 mL 5.0968 mL 10.1937 mL 12.7421 mL
    50 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.0387 mL 2.5484 mL
    100 mM 0.051 mL 0.2548 mL 0.5097 mL 1.0194 mL 1.2742 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2,4-二羟基-6-甲基甲酸乙酯; Ethyl orsellinate CFN97773 2524-37-0 C10H12O4 = 196.20 20mg QQ客服:3257982914
    花椒素; Xanthoxylin CFN97465 90-24-4 C10H12O4 = 196.2 20mg QQ客服:2056216494
    2',4',6'-三甲氧基苯乙酮; 2',4',6'-Trimethoxyacetophenone CFN97980 832-58-6 C11H14O4 = 210.2 20mg QQ客服:2159513211
    母丁香酚; Bancroftinone CFN91180 14964-98-8 C11H14O4 = 210.2 20mg QQ客服:215959384
    苯基甲基甲酮; Acetophenone CFN92881 90536-47-3 C9H10O4 = 182.2 5mg QQ客服:2159513211
    Ebracteolata cpd B; Ebracteolata cpd B CFN92882 83459-37-4 C10H12O4 = 196.2 10mg QQ客服:1457312923
    2,4-二羟基-6-甲氧基-3-乙酰基苯甲醛; 2,4-Dihydroxy-6-methoxy-3-formylacetophenone CFN92880 52117-67-6 C10H10O5 = 210.2 5mg QQ客服:2056216494
    6-[(3’,3’-二甲基烯丙基)氧基]-4-甲氧基-5-甲基苯酞; 3-Deoxyzinnolide CFN97927 17811-32-4 C15H18O4 = 262.3 5mg QQ客服:215959384

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