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  • 花椒毒酚,花椒毒醇

    Xanthotoxol

    花椒毒酚,花椒毒醇
    产品编号 CFN98016
    CAS编号 2009-24-7
    分子式 = 分子量 C11H6O4 = 202.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The fruits of Cnidium monnieri.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    花椒毒酚,花椒毒醇 CFN98016 2009-24-7 10mg QQ客服:1457312923
    花椒毒酚,花椒毒醇 CFN98016 2009-24-7 20mg QQ客服:1457312923
    花椒毒酚,花椒毒醇 CFN98016 2009-24-7 50mg QQ客服:1457312923
    花椒毒酚,花椒毒醇 CFN98016 2009-24-7 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University Sunway Campus (Malaysia)
  • University of Amsterdam (Netherlands)
  • Universidad Industrial de Santander (Colombia)
  • University of Indonesia (Indonesia)
  • The University of Newcastle (Australia)
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  • University of Madras (India)
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  • Universidade Federal de Goias (UFG) (Brazil)
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  • Stanford University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Natural Product Communications2022, 7(3):1-7.
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Industrial Crops and Products2021, 163:113313.
  • Inflammation.2020, 43(5):1716-1728.
  • J Appl Toxicol.2020, 40(7):965-978.
  • Nutrients.2023, 15(3):753.
  • The Korea Journal of Herbology2016, 29-35
  • Pharmacol Rep.2022, 74(1):175-188.
  • Am J Chin Med.2015, 30:1-22
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • Neuropharmacology.2018, 131:68-82
  • Eur J Neurosci.2021, 53(11):3548-3560.
  • Phytochem Anal.2021, 32(6):970-981.
  • Mol Med Rep.2015, 12(5):7789-95
  • BMC Plant Biol.2018, 18(1):122
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  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Acta Physiologiae Plantarum2016, 38:7
  • Molecules.2021, 26(18):5665.
  • Food Science and Biotechnology2015, 2205-2212
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • FEBS Lett.2015, 589(1):182-7
  • Food Chem.2020, 327:126992.
  • ...
  • 生物活性
    Description: Xanthotoxol shows strong pharmacological activities as anti-inflammatory, antioxidant, cytotoxic, dose-graded sedative, 5-HT antagonistic, and neuroprotective effects.Xanthotoxol also has calcium antagonistic effects, it blocks not only the voltage dependent calcium channel, but also the receptor operated calcium channel in the isolated guinea pig atria.
    Targets: IL Receptor | TNF-α | NO | NOS | COX | p65 | NF-kB | DNA/RNA Synthesis | 5-HT Receptor
    In vitro:
    Pol J Pharmacol Pharm. 1992 Jan-Feb;44(1):51-7.
    Cytotoxic effect of xanthotoxol (8-hydroxypsoralen) on TCTC cells in vitro.[Pubmed: 1437852 ]
    The effect of xanthotoxol (8-hydroxypsoralen) on proliferation of TCTC cells in vitro has been studied.
    METHODS AND RESULTS:
    Xanthotoxol at concentrations of 5 to 50 micrograms/ml inhibited the growth of cells. In cultures with xanthotoxol, decreased amount of cell protein, mitotic index, and decreased ability to form a colony, were observed. Moreover, xanthotoxol disturbed mitoses elevating the number of mitotic cells in the telophase stage. An increase of giant and multinuclear cells was also found. On the basis of these results it can be concluded, that 8-hydroxypsoralen which in comparison with other psoralens is not sensitive to photostimulation, inhibits the cell proliferation anyway.
    CONCLUSIONS:
    This fact shows that the mechanism of the psoralens activity is to some extent independent from the photostimulation.
    Evid Based Complement Alternat Med . 2016;2016:5416509.
    Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes[Pubmed: 27034690]
    Abstract Cytochrome p450 (CYP450) enzymes are predominantly involved in Phase I metabolism of xenobiotics. In this study, the CYP450 isoforms involved in xanthotoxol metabolism were identified using recombinant CYP450s. In addition, the inhibitory effects of xanthotoxol on eight CYP450 isoforms and its pharmacokinetic parameters were determined using human liver microsomes. CYP1A2, one of CYP450s, played a key role in the metabolism of xanthotoxol compared to other CYP450s. Xanthotoxol showed stronger inhibition on CYP3A4 and CYP1A2 compared to other isoenzymes with the IC50 of 7.43 μM for CYP3A4 and 27.82 μM for CYP1A2. The values of inhibition kinetic parameters (Ki) were 21.15 μM and 2.22 μM for CYP1A2 and CYP3A4, respectively. The metabolism of xanthotoxol obeyed the typical monophasic Michaelis-Menten kinetics and V max, K m , and CLint values were calculated as 0.55 nmol·min(-1)·mg(-1), 8.46 μM, and 0.06 mL·min(-1)·mg(-1). In addition, the results of molecular docking showed that xanthotoxol was bound to CYP1A2 with hydrophobic and π-π bond and CYP3A4 with hydrogen and hydrophobic bond. We predicted the hepatic clearance (CL H ) and the CL H value was 15.91 mL·min(-1)·kg(-1) body weight. These data were significant for the application of xanthotoxol and xanthotoxol-containing herbs.
    In vivo:
    Cell Mol Neurobiol. 2013 Jul;33(5):715-22.
    Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia.[Pubmed: 23619720]
    We previously found that xanthotoxol, one of the major active ingredients in Cnidium monnieri (L.) Cusson, exerts protective effects in a rat model of focal cerebral ischemia/reperfusion injury by alleviating brain edema, inhibiting the neutrophil infiltration, and decreasing the expression of intercellular adhesion molecule-1 (ICAM-1) and E-selectin.
    METHODS AND RESULTS:
    The present study was designed to further determine the possible mechanisms of action of neuroprotective properties of xanthotoxol after cerebral ischemia. Transient focal cerebral ischemia/reperfusion model in male Sprague-Dawley rats was induced by 2-h middle cerebral artery occlusion followed by 24-h reperfusion. Xanthotoxol (5 and 10 mg/kg) or vehicle were administered intraperitoneally at 1 and 12 h after the onset of ischemia. At 24 h after reperfusion, we assessed the effect of xanthotoxol on the blood-brain barrier (BBB) permeability, the production of pro-inflammatory mediators such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-8, nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and the p65 subunit of the transcription factor, nuclear factor-κB (NF-κB) in the cortex after ischemic insult. The results showed that xanthotoxol treatment significantly attenuated BBB disruption, reduced the IL-1β, TNF-α, IL-8 and NO level, and attenuated the iNOS activity compared with vehicle-treated animals. Further, xanthotoxol treatment also significantly prevented the ischemia/reperfusion-induced increase in the protein expression of iNOS, COX-2, and the nuclear NF-κB p65.
    CONCLUSIONS:
    These results, taken together with those of our previous study, suggest that the neuroprotection may be attributed to the ability of xanthotoxol to attenuate the expression of pro-inflammatory mediators and thereby inhibit the inflammatory response after cerebral ischemia.
    Zhong Yao Cai. 2005 Apr;28(4):319-21.
    Calcium antagonistic effect of Xanthotoxol on isolated guinea pig atria.[Pubmed: 16104510]
    To study the mechanism of depressant effect of xanthotoxol (XT) on contractility in the isolated guinea pig atria.
    METHODS AND RESULTS:
    The contractile force of the isolated left atria was determined by tension recording method. In the experiments on contractility of the left atria XT and Verapamil (Ver) significantly depressed the positive staircase phenomena, which was reversed by Ver but not by XT. However, the post-rest potentiation of myocardial contraction in the left atria was only markedly decreased by XT but not by Ver. Furthermore, XT not only attenuated the positive inotropic action, but also delayed the following toxicity response induced by ouabain in the isolated left atria.
    CONCLUSIONS:
    XT blocked not only the voltage dependent calcium channel, but also the receptor operated calcium channel in the isolated guinea pig atria.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.9456 mL 24.728 mL 49.456 mL 98.912 mL 123.64 mL
    5 mM 0.9891 mL 4.9456 mL 9.8912 mL 19.7824 mL 24.728 mL
    10 mM 0.4946 mL 2.4728 mL 4.9456 mL 9.8912 mL 12.364 mL
    50 mM 0.0989 mL 0.4946 mL 0.9891 mL 1.9782 mL 2.4728 mL
    100 mM 0.0495 mL 0.2473 mL 0.4946 mL 0.9891 mL 1.2364 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    三甲沙林; Trioxsalen CFN70355 3902-71-4 C14H12O3 = 228.2 5mg QQ客服:1457312923
    花椒毒酚,花椒毒醇; Xanthotoxol CFN98016 2009-24-7 C11H6O4 = 202.2 20mg QQ客服:2056216494
    花椒毒素; 8-甲氧基补骨脂素; Xanthotoxin CFN98372 298-81-7 C12H8O4 = 216.2 20mg QQ客服:3257982914
    佛手酚葡萄糖苷; Bergaptol-beta-glucopyranoside CFN95186 131623-13-7 C17H16O9 = 364.3 10mg QQ客服:1457312923
    8-羟基-5-O-beta-D-吡喃葡萄糖补骨脂素; 8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen CFN98663 425680-98-4 C17H16O10 = 380.3 5mg QQ客服:1457312923
    香柑醇; 5-羟基-6,7-呋喃并香豆素; Bergaptol CFN98772 486-60-2 C11H6O4 = 202.2 20mg QQ客服:1413575084
    佛手苷内酯; Bergapten CFN98766 484-20-8 C12H8O4 = 216.2 20mg QQ客服:2056216494
    8-羟基佛手苷内酯; 8-Hydroxybergapten CFN90591 1603-47-0 C12H8O5 = 232.19 10mg QQ客服:2056216494
    异茴芹灵; Isopimpinellin CFN98752 482-27-9 C13H10O5 = 246.2 20mg QQ客服:215959384
    Rivulobirin B; Rivulobirin B CFN99893 194145-29-4 C23H12O9 = 432.3 5mg QQ客服:1413575084

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