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  • Vitisin B

    Vitisin B

    Vitisin B
    产品编号 CFN93805
    CAS编号 184362-10-5
    分子式 = 分子量 C25H25O12 = 517.45
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The fruits of Vitis thunbergii var. taiwaniana.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Vitisin B CFN93805 184362-10-5 1mg QQ客服:2056216494
    Vitisin B CFN93805 184362-10-5 5mg QQ客服:2056216494
    Vitisin B CFN93805 184362-10-5 10mg QQ客服:2056216494
    Vitisin B CFN93805 184362-10-5 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Max Rubner-Institut (MRI) (Germany)
  • Universidade do Porto (Portugal)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Sapienza University of Rome (Italy)
  • Amity University (India)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • University of Hertfordshire (United Kingdom)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Chinese University of Hong Kong (China)
  • Anna University (India)
  • VIT University (India)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biomolecules.2020, 10(2):E184
  • BMC Complement Altern Med.2018, 18(1):303
  • Korean Journal of Pharmacognosy2018, 49(3):270-277
  • Arch Biochem Biophys.2020, 687:108363.
  • Analytical Letters.2020, doi 10.1008
  • Heliyon.2023, e12778.
  • J.Pharm. & Biome. Anal.2023, 2: 100018.
  • Biomed Pharmacother.2019, 111:262-269
  • Asian Pac J Tropical Bio.2020, 10(6):239-247
  • Front. Plant Sci.2022, 13:757852.
  • Korean J. Food Sci. & Technol.2022, 54(2):241-246
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • Molecules.2018, 23(7):E1817
  • Chemistry of Plant Materials.2016, 33-46
  • Cancers (Basel).2023, 15(1):293.
  • Separation Science Plus2022, sscp.202200048.
  • Pharmacol Rep.2020, 72(2):472-480.
  • Int J Mol Sci.2022, 23(10):5813.
  • Anticancer Res.2018, 38(4):2127-2135
  • ...
  • 生物活性
    Description: Vitisin B can stimulate osteoblastogenesis via estrogen receptor-mediated pathway, it can inhibits migration through inhibition of PDGF signaling and enhancement of cell adhesiveness in cultured vascular smooth muscle cells. (-)-Vitisin B can significantly inhibit cell proliferation through inducing cell apoptosis in human HL-60 promyelocytic leukemia cells, it induces apoptosis of leukemia cells might be mediated through activation of JNK and Fas death-signal transduction.
    Targets: Estrogen receptor | JNK | Caspase | PARP | PDGFR | Bcl-2/Bax | Progestogen receptor
    In vitro:
    Toxicol Appl Pharmacol. 2011 Oct 15;256(2):198-208.
    Vitisin B, a resveratrol tetramer, inhibits migration through inhibition of PDGF signaling and enhancement of cell adhesiveness in cultured vascular smooth muscle cells.[Pubmed: 21871475 ]
    Vascular smooth muscle cells (VSMCs) play an important role in normal vessel formation and in the development and progression of cardiovascular diseases. Grape plants contain resveratrol monomer and oligomers and drinking of wine made from grape has been linked to "French Paradox". In this study we evaluated the effect of Vitisin B, a resveratrol tetramer, on VSMC behaviors.
    METHODS AND RESULTS:
    Vitisin B inhibited basal and PDGF-induced VSMC migration. Strikingly, it did not inhibit VSMC proliferation but inversely enhanced cell cycle progression and proliferation. Among the tested resveratrol oligomers, Vitisin B showed an excellent inhibitory activity and selectivity on PDGF signaling. The anti-migratory effect by Vitisin B was due to direct inhibition on PDGF signaling but was independent of interference with PDGF binding to VSMCs. Moreover, the enhanced VSMC adhesiveness to matrix contributed to the anti-migratory effect by Vitisin B. Fluorescence microscopy revealed an enhanced reorganization of actin cytoskeleton and redistribution of activated focal adhesion proteins from cytosol to the peripheral edge of the cell membrane. This was confirmed by the observation that enhanced adhesiveness was repressed by the Src inhibitor. Finally, among the effects elicited by Vitisin B, only the inhibitory effect toward basal migration was partially through estrogen receptor activation.
    CONCLUSIONS:
    We have demonstrated here that a resveratrol tetramer exhibited dual but opposite actions on VSMCs, one is to inhibit VSMC migration and the other is to promote VSMC proliferation. The anti-migratory effect was through a potent inhibition on PDGF signaling and novel enhancement on cell adhesion.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9326 mL 9.6628 mL 19.3255 mL 38.6511 mL 48.3138 mL
    5 mM 0.3865 mL 1.9326 mL 3.8651 mL 7.7302 mL 9.6628 mL
    10 mM 0.1933 mL 0.9663 mL 1.9326 mL 3.8651 mL 4.8314 mL
    50 mM 0.0387 mL 0.1933 mL 0.3865 mL 0.773 mL 0.9663 mL
    100 mM 0.0193 mL 0.0966 mL 0.1933 mL 0.3865 mL 0.4831 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    氯化矮牵牛素; Petunidin chloride CFN92036 1429-30-7 C16H13ClO7 = 352.7 5mg QQ客服:2056216494
    氯化矮牵牛素-3-O-阿拉伯糖苷; Petunidin-3-O-arabinoside chloride CFN92044 28500-03-0 C21H21ClO11 = 484.8 5mg QQ客服:215959384
    氯化矮牵牛素-3-O-半乳糖苷; Petunidin-3-O-galactoside chloride CFN92042 28500-02-9 C22H23ClO12 = 514.9 5mg QQ客服:1457312923
    氯化矮牵牛素-3-O-葡萄糖苷; Petunidin-3-O-glucoside chloride CFN92043 6988-81-4 C22H23ClO12 = 514.9 5mg QQ客服:2056216494
    氯化锦葵色素; Malvidin chloride CFN92035 643-84-5 C17H15ClO7 = 366.8 10mg QQ客服:2056216494
    氯化锦葵色素-3-O-阿拉伯糖苷; Malvidin-3-O-arabinoside chloride CFN92050 28500-04-1 C22H23ClO11 = 498.9 5mg QQ客服:1413575084
    氯化锦葵色素-3-O-半乳糖苷; Malvidin-3-O-galactoside chloride CFN92048 30113-37-2 C23H25ClO12 = 528.9 10mg QQ客服:2056216494
    氯化锦葵色素-3-O-葡萄糖苷; Malvidin-3-O-glucoside chloride CFN92049 7228-78-6 C23H25ClO12 = 528.9 10mg QQ客服:1457312923
    氯化锦葵色素-3,5-O-双葡萄糖苷; Malvidin-3,5-O-diglucoside chloride CFN91867 16727-30-3 C29H35ClO17 = 691.0 10mg QQ客服:2159513211
    Vitisin B; Vitisin B CFN93805 184362-10-5 C25H25O12 = 517.45 5mg QQ客服:1457312923

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