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  • 牡荆素7-O-葡萄糖苷

    Vitexin 7-glucoside

    牡荆素7-O-葡萄糖苷
    产品编号 CFN70343
    CAS编号 35109-95-6
    分子式 = 分子量 C27H30O15 = 594.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Crataegus pinnatifida Bge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    牡荆素7-O-葡萄糖苷 CFN70343 35109-95-6 1mg QQ客服:215959384
    牡荆素7-O-葡萄糖苷 CFN70343 35109-95-6 5mg QQ客服:215959384
    牡荆素7-O-葡萄糖苷 CFN70343 35109-95-6 10mg QQ客服:215959384
    牡荆素7-O-葡萄糖苷 CFN70343 35109-95-6 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universit?t Basel (Switzerland)
  • Universidade Católica Portuguesa (Portugal)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Auckland (New Zealand)
  • University of Padjajaran (Indonesia)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Malaya (Malaysia)
  • University of Mysore (India)
  • MTT Agrifood Research Finland (Finland)
  • VIT University (India)
  • University of Dicle (Turkey)
  • Utrecht University (Netherlands)
  • University of Parma (Italy)
  • University Medical Center Mainz (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2021, 337:128023.
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Nat Plants.2016, 3:16205
  • Research J. Pharm. and Tech.2020, 13(7):3059-3064.
  • JAOCS2021, 98(7):779-794.
  • Int J Mol Sci.2020, 21(9):3239.
  • RSC Advances2017, 86
  • Front Plant Sci.2023, 14:1207940.
  • Phytother Res.2019, 33(4):1104-1113
  • J Ethnopharmacol.2020, 249:112381
  • Cell Death Dis.2019, 10(12):882
  • Exp Mol Med.2020, 52(4):629-642.
  • Chemistry of Plant Materials.2019, 129-136
  • FASEB J.2022, 36(7):e22387.
  • Oncotarget.2017, 8(64):108006-108019
  • Int J Mol Sci.2021, 22(19):10220.
  • Biomed Pharmacother.2021, 139:111585.
  • Front Plant Sci.2020, 10:1705
  • J Breast Cancer.2015, 18(2):112-118
  • Microbiol. Biotechnol. Lett.2022, 50(2): 193-201.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • Food Funct.2022, 13(23):12105-12120.
  • Phytomedicine.2019, 57:95-104
  • ...
  • 生物活性
    Description: Vitexin-7-glucoside exhibits high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.
    In vitro:
    European Journal of Medicinal Chemistry, 2006, 41(5):605-610.
    Prediciton of human absorption of natural compounds by the non-everted rat intestinal model.[Reference: WebLink]
    A major concern in natural drug research is that many substances with potent biological activity in vitro are unable to generate good activity in vivo owing to their poor water-solubility, poor permeability and/or poor stability. The permeability of drug candidates across the intestinal mucosa is one of the most important factors in defining drug bioavailability and biological activity. In order to screen promising compounds for further investigation, a non-everted rat intestinal sac model has been developed successfully to assay the permeability of natural compounds and to predict their human absorption.
    METHODS AND RESULTS:
    In this system, the drug solution was placed in non-everted intestinal sacs (NEIS), which were placed in an acceptor solution and the permeability of drug across intestine walls was determined. The feasibility of this method has been validated and demonstrated for 11 model compounds chosen from currently marketed drugs whose human fraction absorbed (Fa) data have been reported. The results of the studies indicate that a good relationship exists between the permeability of the model drugs and their corresponding Fa data. The permeability of 13 natural compounds was evaluated using this system. Only fraxinellone and vitexin 7-glucoside exhibited high intestinal permeability, and predictive of excellent human absorption, which awaits confirmation from further investigation in vivo.
    CONCLUSIONS:
    This model provides an alternative method to everted intestinal sacs for the evaluation of in vitro permeability in rats, and for estimating human absorption of drugs. It may therefore hold great promise for oral absorption screening of new drug candidates.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6821 mL 8.4104 mL 16.8209 mL 33.6417 mL 42.0521 mL
    5 mM 0.3364 mL 1.6821 mL 3.3642 mL 6.7283 mL 8.4104 mL
    10 mM 0.1682 mL 0.841 mL 1.6821 mL 3.3642 mL 4.2052 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6728 mL 0.841 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    牡荆素精铵酸盐; Vitexin argininate CFN93575 N/A C27H34N4O12 = 606.6 5mg QQ客服:2056216494
    牡荆素7-O-葡萄糖苷; Vitexin 7-glucoside CFN70343 35109-95-6 C27H30O15 = 594.5 5mg QQ客服:2056216494
    2''-O-p-香豆酰基牡荆素; Vitexin 2''-O-p-coumarate CFN90654 59282-55-2 C30H26O12 = 578.5 5mg QQ客服:215959384
    4-甲氧基牡荆素; 4'-O-Methylvitexin CFN90500 2326-34-3 C22H22O10 = 446.12 5mg QQ客服:1413575084
    Margaritene; Margaritene CFN95303 64271-10-9 C28H32O14 = 592.6 10mg QQ客服:2056216494
    砂生槐黄酮 A; Sophoraflavone A CFN95510 105594-08-9 C27H30O13 = 562.5 10mg QQ客服:2056216494
    牡荆素-2''-O-鼠李糖苷; Vitexin-2''-O-rhamnoside CFN98177 64820-99-1 C27H30O14 = 578.52 20mg QQ客服:215959384
    牡荆素-2''-O-葡萄糖苷; Vitexin 2''-glucoside CFN70421 61360-94-9 C27H30O15 = 594.5 5mg QQ客服:3257982914
    牡荆素 2''-O-(4'''-O-乙酰)鼠李糖苷; Vitexin 2''-O-(4'''-O-acetyl)rhamnoside CFN96447 80537-98-0 C29H32O15 = 620.56 5mg QQ客服:3257982914
    牡荆素-4''-O-葡萄糖苷; Vitexin -4''-O-glucoside CFN92072 178468-00-3 C27H30O15 = 594.5 20mg QQ客服:215959384

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