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  • 齿阿米素; 甲氧呋豆素

    Visnagin

    齿阿米素; 甲氧呋豆素
    产品编号 CFN97314
    CAS编号 82-57-5
    分子式 = 分子量 C13H10O4 = 230.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Ammi visnaga.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    齿阿米素; 甲氧呋豆素 CFN97314 82-57-5 10mg QQ客服:1413575084
    齿阿米素; 甲氧呋豆素 CFN97314 82-57-5 20mg QQ客服:1413575084
    齿阿米素; 甲氧呋豆素 CFN97314 82-57-5 50mg QQ客服:1413575084
    齿阿米素; 甲氧呋豆素 CFN97314 82-57-5 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Calcutta University (India)
  • Amity University (India)
  • Lodz University of Technology (Poland)
  • University of Illinois at Chicago (USA)
  • Medical University of Gdansk (Poland)
  • University of Pretoria (South Africa)
  • University of Madras (India)
  • Kyoto University (Japan)
  • University of Toronto (Canada)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University of Vigo (Spain)
  • Monash University Sunway Campus (Malaysia)
  • The University of Newcastle (Australia)
  • Utah State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Drug Des Devel Ther.2020, 14:61-71
  • Sci Rep. 2018, 462(8)
  • Microorganisms.2021, 9(12):2514.
  • Academic J of Second Military Medical University2018, 39(11)
  • Phytomedicine.2019, 65:153089
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Pharmaceuticals (Basel). 2021, 14(10):986.
  • Microchemical Journal2018, 137:168-173
  • J Korean Society of Food Science & Nutrition2021, 50(9): 962-970
  • FASEB J.2019, 33(2):2026-2036
  • Phytomedicine2022, 104:154337.
  • J Nat Prod.2019, 82(4):1002-1008
  • Chem Biol Interact.2022, 368:110248.
  • Biochem Systematics and Ecology2017, 11-18
  • Antioxidants (Basel).2020, 9(6):544.
  • J Biochem Mol Toxicol.2020, 34(7):e22489.
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • J. Pharm. Res. Int.2022, 34(58): pp.1-14.
  • BMC Complement Altern Med.2016, 16:213
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • Int J Mol Sci.2022, 23(20):12516.
  • Journal of Analytical Chemistry2017, 854-861
  • Antioxidants (Basel).2020, 9(4):284.
  • ...
  • 生物活性
    Description: Visnagin has acute hypotensive, anti-inflammatory, and neuroprotective effects, it protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Visnagin can relax aortae previously contracted by noradrenaline, and weakly inhibit the hydrolytic activity of the cyclic nucleotide phosphodiesterase (PDE) isozymes (PDE5, PDE4, PDE3, cyclic GMP activated PDE2 and PDE1).
    Targets: IL Receptor | TNF-α | COX | P450 (e.g. CYP17) | NOS | AP-1 | NF-kB | IFN-γ | PDE
    In vitro:
    PLoS One. 2013 Sep 19;8(9):e74917.
    Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells.[Pubmed: 24069365]
    Khellin and Visnagin are two furanochromones that can be frequently found in ethnomedical formulations in Asia and the Middle East. Both compounds possess anti-inflammatory and analgesic properties, therefore modern medicine uses these compounds or structurally related derivatives for treatment of vitiligo, bronchial asthma and renal colics. Despite their frequent usage, the potential toxic properties of Visnagin and khellin are not well characterized up-to-now.
    METHODS AND RESULTS:
    The observed induction of several other members of the AHR gene battery, whose gene products are involved in regulation of cell growth, differentiation and migration, indicates that a further toxicological characterization of Visnagin and khelllin is urgently required in order to minimize potential drug-drug interactions and other toxic side-effects that may occur during therapeutic usage of these furanochromones.
    In vivo:
    Korean J Physiol Pharmacol. 2010 Oct;14(5):257-63.
    Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus.[Pubmed: 21165322 ]
    Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g][1]-benzopyran-5-one), which is an active principle extracted from the fruits of Ammi visnaga, has been used as a treatment for low blood-pressure and blocked blood vessel contraction by inhibition of calcium influx into blood cells. However, the neuroprotective effect of Visnagin was not clearly known until now.
    METHODS AND RESULTS:
    Thus, we investigated whether Visnagin has a neuroprotective effect against kainic acid (KA)-induced neuronal cell death. In the cresyl violet staining, pre-treatment or post-treatment Visnagin (100 mg/kg, p.o. or i.p.) showed a neuroprotective effect on KA (0.1 μg) toxicity. KA-induced gliosis and proinflammatory marker (IL-1β, TNF-α, IL-6, and COX-2) inductions were also suppressed by Visnagin administration.
    CONCLUSIONS:
    These results suggest that Visnagin has a neuroprotective effect in terms of suppressing KA-induced pathogenesis in the brain, and that these neuroprotective effects are associated with its anti-inflammatory effects.
    Planta Med. 2000 Feb;66(1):35-9.
    Cardiovascular effects of visnagin on rats.[Pubmed: 10705731]
    The present article describes the effects of visnagin on systolic blood pressure and heart rate in the anaesthetized rat.
    METHODS AND RESULTS:
    Intravenous administration of visnagin (0.3-5 mg kg-1) produced dose-related decreases in blood pressure with no significative changes in heart rate. Under nitric oxide synthase inhibition (L-NAME, 50 mg kg-1) the hypotensive effects of visnagin (5 mg kg-1) were not affected. Visnagin (5 x 10(-6) M-10(-4) M) produced a weak decrease in the rate and amplitude of spontaneous contractions in right atria. Visnagin also caused a weak decrease in peak contractile force and the df/dtmax with no significant changes in the time to peak tension or the time for total contraction in left atria driven at a basal rate of 1 Hz. Visnagin (10(-5) M, 5 x 10(-5) M and 10(-4) M) concentration-dependently decreased pressor response to KCl (IC50 = 5.1 +/- 2.5 x 10(-5) M) and noradrenaline (IC50 = 2.6 +/- 0.9 x 10(-5) M) in rat isolated mesenteric beds. Visnagin (3 x 10(-7) M-10(-4) M) induced a concentration-dependent relaxation of isolated mesenteric arteries contracted by noradrenaline (IC50 = 1.7 +/- 0.8 x 10(-5) M). The relaxant effects in the absence of functional endothelium were not significantly different (IC50 = 1.5 +/- 0.3 x 10(-5) M, P > 0.05) from those observed in segments with intact endothelium.
    CONCLUSIONS:
    In conclusion, the main mechanism responsible for the acute hypotensive effect of visnagin is the vasorelaxant response induced by this drug in resistance arteries.
    Biomed Pharmacother . 2019 Apr;112:108629.
    Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction[Pubmed: 30798137]
    Abstract Acute pancreatitis (AP) is an exocrine dysfunction of the pancreas where oxidative stress and inflammatory cytokines play a key role in induction and progression of the disease. Studies have demonstrated that antioxidant phytochemicals have been effective in improving pancreatitis condition, but there are no clinically approved drugs till date. Our study aims to assess the preventive activity of visnagin, a novel phytochemical isolated from Ammi visnaga against cerulein induced AP. Male Swiss albino mice were divided into six groups (n = 6, each group) comprising of normal control, cerulein control, seven day pre-treatment with visnagin at three dose levels; visnagin low dose (10 mg/kg), visnagin mid dose (30 mg/kg), visnagin high dose (60 mg/kg) and visnagin control (60 mg/kg). AP was induced by six injections of cerulein (50 μg/kg, i.p.) on the 7th day and the animals were sacrificed after 6 h of last cerulein dose. Various markers of pancreatic function, oxidative stress and inflammation were assessed. Visnagin was found to be effective in reducing plasma amylase and lipase levels, reduced cerulein induced oxidative stress. Visnagin dose dependently decreased the expression of IL-1β, IL-6, TNF-α and IL-17. It attenuated the levels of nuclear p65-NFκB. Visnagin improved the antioxidant defence by improving Nrf2 expression and halted pancreatic inflammation by suppressing NFκB and nitrotyrosine expression in the acinar cells. Further, it attenuated the expression of markers of multiple organ dysfunction syndrome and reduced inflammatory cytokines in lungs and intestine. Cumulatively, these findings indicate that visnagin has substantial potential to prevent cerulein induced AP. Keywords: Acute pancreatitis; Inflammation; NFκB; Nitrotyrosine; Nrf2; Visnagin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.344 mL 21.7202 mL 43.4405 mL 86.881 mL 108.6012 mL
    5 mM 0.8688 mL 4.344 mL 8.6881 mL 17.3762 mL 21.7202 mL
    10 mM 0.4344 mL 2.172 mL 4.344 mL 8.6881 mL 10.8601 mL
    50 mM 0.0869 mL 0.4344 mL 0.8688 mL 1.7376 mL 2.172 mL
    100 mM 0.0434 mL 0.2172 mL 0.4344 mL 0.8688 mL 1.086 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6-O-呋喃芹糖基-5-O-甲基维斯阿米醇苷; 6-O-apiosyl-5-O-Methylvisammioside CFN90982 139446-82-5 C27H36O14 = 584.57 5mg QQ客服:1413575084
    升麻素 4'-O-beta-D-葡萄糖苷; Cimifugin 4'-O-beta-D-glucopyranoside CFN90976 1632110-81-6 C22H28O11 = 468.45 5mg QQ客服:2056216494
    亥茅酚; Hamaudol CFN95115 735-46-6 C15H16O5 = 276.3 10mg QQ客服:2056216494
    3'-O-当归酰基亥茅酚; 3'-O-Angeloylhamaudol CFN91666 84272-84-4 C20H22O6 = 358.39 5mg QQ客服:1457312923
    亥茅酚苷; Sec-O-Glucosylhamaudol CFN99743 80681-44-3 C21H26O10 = 438.43 20mg QQ客服:2159513211
    Isoapetalic acid; Isoapetalic acid CFN98450 34366-34-2 C22H28O6 = 388.5 5mg QQ客服:2056216494
    齿阿米素; 甲氧呋豆素; Visnagin CFN97314 82-57-5 C13H10O4 = 230.2 20mg QQ客服:2056216494
    4-羟基-7-(羟基甲基)-5H-呋喃并[3,2-g][1]苯并吡喃-5-酮; Norkhellol CFN98679 4439-68-3 C12H8O5 = 232.2 5mg QQ客服:215959384
    当归碱; Angelicain CFN98789 49624-66-0 C15H16O6 = 292.3 5mg QQ客服:1413575084
    升麻素; Cimifugin CFN98612 37921-38-3 C16H18O6 = 306.3 20mg QQ客服:215959384

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