环氧长春碱,长春素
Vinleurosine
|
产品编号 |
CFN90466 |
CAS编号 |
23360-92-1 |
分子式 = 分子量 |
C46H56N4O9 = 808.95 |
产品纯度 |
>=98% |
物理属性 |
Cryst. |
化合物类型 |
Alkaloids |
植物来源 |
The herbs of Catharanthus roseus (L.) G. Don |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
环氧长春碱,长春素 |
CFN90466 |
23360-92-1 |
1mg |
QQ客服:1457312923 |
环氧长春碱,长春素 |
CFN90466 |
23360-92-1 |
5mg |
QQ客服:1457312923 |
环氧长春碱,长春素 |
CFN90466 |
23360-92-1 |
10mg |
QQ客服:1457312923 |
环氧长春碱,长春素 |
CFN90466 |
23360-92-1 |
20mg |
QQ客服:1457312923 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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MTT Agrifood Research Finland (Finland)
Uniwersytet Medyczny w ?odzi (Poland)
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Rio de Janeiro State University (Brazil)
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国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
Vinleurosine can partially inhibit the energy dependent transport of alpha-aminoisobutyric acid in Ehrlich ascites tumor cells. |
In vitro: |
J Cell Physiol. 1975 Oct;86(2 Pt 1):201-11. | A reduction in energy-dependent amino acid transport by microtubular inhibitors in Ehrlich ascites tumor cells.[Pubmed: 1194361] | Vincristine, other periwinkle alkaloids, and colchicine partially inhibit the energy dependent transport of alpha-aminoisobutyric acid in Ehrlich ascites tumor cells. The properties of this phenomenon were characterized in detail for vincristine. Maximum depression of the steady-state intracellular alpha-aminoisobutyric acid level was achieved with a vincristine concentration of less than 0.5 muM. The inhibitory effect of vincristine increases as the extracellular alpha-aminoisobutyric acid concentration is increased reaching a maximum, however, of only approximately to 25% at a level of 5 mM, leaving a large gradient for alpha-aminoisobutyric acid across the cell membrane. Vincristine produced an asymmetrical uptake rate, while increasing the efflux of alpha-aminoisobutyric acid. Inhibition of net alpha-aminoisobutyric acid transport by vincristine was partially reversible (approximately to 40%). Colchicine (50 muM) reduced the steady-state alpha-aminoisobutyric acid level by 30%, an effect that was not reversible. Inhibition by vinleurosine and vinrosidine was comparable to that of vincristine. Addition of glucose to the medium resulted in a small, but significant, decrease in the inhibitory effects of both vincristine and colchicine. The data indicate that these agents inhibit a small component of the uphill transport of alpha-aminoisobutyric acid in Ehrlich ascites tumor cells. The inhibitory effect of vincristine cannot be attributed to an increase in the passive permeability of the cell membrane to this agent. Rather, the data along with other studies from this laboratory suggest that vincristine reduces the energy-dependent transport of alpha-aminoisobutyric acid by either inhibiting cellular energy metabolism or by inhibiting cellular energy metabolism or by inhibiting the coupling of energy-metabolism to the transport of this amino acid and raises the possibility that cellular microtubules play a role in these processes. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
1.2362 mL |
6.1809 mL |
12.3617 mL |
24.7234 mL |
30.9043 mL |
5 mM |
0.2472 mL |
1.2362 mL |
2.4723 mL |
4.9447 mL |
6.1809 mL |
10 mM |
0.1236 mL |
0.6181 mL |
1.2362 mL |
2.4723 mL |
3.0904 mL |
50 mM |
0.0247 mL |
0.1236 mL |
0.2472 mL |
0.4945 mL |
0.6181 mL |
100 mM |
0.0124 mL |
0.0618 mL |
0.1236 mL |
0.2472 mL |
0.309 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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