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  • 硫酸长春碱

    Vinblastine Sulfate

    硫酸长春碱
    产品编号 CFN90146
    CAS编号 143-67-9
    分子式 = 分子量 C46H58N4O9.H2SO4 = 909.06
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Catharanthus roseus (L.)G. Don
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    硫酸长春碱 CFN90146 143-67-9 10mg QQ客服:2159513211
    硫酸长春碱 CFN90146 143-67-9 20mg QQ客服:2159513211
    硫酸长春碱 CFN90146 143-67-9 50mg QQ客服:2159513211
    硫酸长春碱 CFN90146 143-67-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Sao Paulo (Brazil)
  • Gyeongsang National University (Korea)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • University of South Australia (Australia)
  • Monash University Malaysia (Malaysia)
  • University of Vigo (Spain)
  • Auburn University (USA)
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  • University of Toronto (Canada)
  • University of Illinois at Chicago (USA)
  • University of Minnesota (USA)
  • Sri Ramachandra University (India)
  • Chiang Mai University (Thailand)
  • University of Wollongong (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • J Inflamm Res.2022, 15:5347-5359.
  • Sci Rep.2023, 13(1):14594.
  • J Sep Sci.2020, 201901140
  • Natural Product Communications2020, doi: 10.1177.
  • Nutrients.2021, 13(10):3414.
  • J. Pharm. Res. Int.2022, 34(58): pp.1-14.
  • APMIS.2019, 127(10):688-695
  • Exp Parasitol.2017, 183:160-166
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Tropical Journal of Pharmaceutical Research 2021, 20(6):1165-1170.
  • Phytother Res.2018, 32(5):923-932
  • Antiviral Res.2021, 193:105142.
  • Int J Nanomedicine.2022, 17:6513-6525.
  • Appl. Sci. 2021, 11(22),10569
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Int. J. of Food Properties2017, S108-S118
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • J Cosmet Dermatol.2022, 21(1):396-402.
  • Journal of Food Quality2022, P:13, 6256310.
  • Mol Pharm.2018, 15(8):3285-3296
  • PLoS One.2017, 12(3):e0173585
  • ...
  • 生物活性
    Description: Vinblastine Sulfate has anticancer activity, using FA-BSANPs as a drug carrier system could be effective in targeting Vinblastine Sulfate-sensitive tumors in the future. Vinblastine Sulfate could offer protection to the normal tissues against gamma-radiation-induced DNA strand breaks. The changes induced on the rabbit OM by Vinblastine sulphate are transient and that regenerative recovery leads to the restoration of the normal structure of the mucosa.
    Targets: DNA/RNA Synthesis
    In vitro:
    Mutat Res. 2003 Apr 20;536(1-2):15-25.
    Effect of vinblastine sulfate on gamma-radiation-induced DNA single-strand breaks in murine tissues.[Pubmed: 12694742]
    The effect of vinblastine sulfate on gamma-radiation-induced DNA strand breaks in different tissues of tumour bearing mice, was studied by single-cell gel electrophoresis.
    METHODS AND RESULTS:
    Intraperitonial administration of different doses (0.25-2.0mg/kg body weight) of vinblastine sulfate 30 min prior to 4 Gy gamma-radiation exposure showed a dose-dependent decrease in the yield of DNA strand breaks in murine fibrosarcoma, blood leukocytes and bone marrow cells. The dose-dependent protection of cellular DNA against radiation-induced strand breaks as evidenced from comet tail length, tail moment and percent DNA in the tail, was more pronounced in bone marrow cells than in the cells of the tumor fibrosarcoma. In fibrosarcoma cells, the decrease in comet tail length, tail moment and percent DNA in the tail was detected at lower doses of vinblastine sulfate administration and these parameters were not significantly altered at higher doses, from that of the control irradiated.
    CONCLUSIONS:
    From this study, it appears that in addition to anticancer activity, vinblastine sulfate could offer protection to the normal tissues against gamma-radiation-induced DNA strand breaks.
    In vivo:
    Anat Histol Embryol. 2012 Oct;41(5):374-87.
    Anticancer drug vinblastine sulphate induces transient morphological changes on the olfactory mucosa of the rabbit.[Pubmed: 22443492]
    Vinblastine Sulfate (VBS) is an anticancer drug that acts by disrupting microtubule dynamics of highly mitotic tissue cells. The consequences of Vinblastine sulphate on the olfactory mucosa (OM), a tissue with high mitotic numbers, are not clearly understood.
    METHODS AND RESULTS:
    We used qualitative and quantitative methods to determine the structural changes that may be produced on the rabbit OM by Vinblastine sulphate. Following a single dose (0.31 mg/kg) of this drug, the structure of the mucosa was greatly altered on the first 3-5 days. The alteration was characterized by disarrangement of the normal layering of nuclei of the epithelia, degeneration of axonal bundles, occurrence of blood vessels within the bundles, localized death of cells of Bowman's glands and glandular degeneration. Surprisingly on or after day 7 and progressively to day 15 post-exposure, the OM was observed to regenerate and acquire normal morphology, and the vessels disappeared from the bundles. Relative to control values, bundle diameters, olfactory cell densities and cilia numbers decreased to as low as 53.1, 75.2 and 71.4%, respectively, on day 5. Volume density for the bundles, which was 28.6% in controls, decreased to a lowest value of 16.8% on day 5. In contrast, the volume density for the blood vessels was significantly lower in controls (19.9%) than in treated animals at day 2 (25.8%), day 3 (34.3%) and day 5 (31.5%).
    CONCLUSIONS:
    These findings suggest that the changes induced on the rabbit OM by Vinblastine sulphate are transient and that regenerative recovery leads to the restoration of the normal structure of the mucosa.
    Can Med Assoc J. 1970 Feb 14;102(3):278-80.
    A comparison of nitrogen mustard and vinblastine sulfate in the treatment of patients with Hodgkin's disease.[Pubmed: 5414540]

    METHODS AND RESULTS:
    In a crossover study the effectiveness of intermittent maintenance doses of nitrogen mustard was compared to that of vinblastine sulfate in the treatment of 61 patients with advanced Hodgkin's disease. Forty-five of the patients had had previous radiation therapy. Nine of 29 patients who received nitrogen mustard as the first drug had a complete response and five had a partial response. The comparative results in 32 patients receiving vinblastine sulfate first were nine complete responses and 13 partial responses. The median duration of the complete responses to each drug was 43 weeks. The partial responses were of shorter duration. When the second drug was given in adequate doses, almost as many patients responded with a similar median duration of response.
    CONCLUSIONS:
    It is concluded that nitrogen mustard and vinblastine sulfate are equally effective single agents in the treatment of patients with advanced Hodgkin's disease and that patient preference would favour vinblastine sulfate because of its negligible side effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1 mL 5.5002 mL 11.0004 mL 22.0007 mL 27.5009 mL
    5 mM 0.22 mL 1.1 mL 2.2001 mL 4.4001 mL 5.5002 mL
    10 mM 0.11 mL 0.55 mL 1.1 mL 2.2001 mL 2.7501 mL
    50 mM 0.022 mL 0.11 mL 0.22 mL 0.44 mL 0.55 mL
    100 mM 0.011 mL 0.055 mL 0.11 mL 0.22 mL 0.275 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    酒石酸长春瑞滨; Vinorelbine Tartrate CFN90142 125317-39-7 C53H66N4O20 = 1079.11 20mg QQ客服:1457312923
    硫酸长春碱; Vinblastine Sulfate CFN90146 143-67-9 C46H58N4O9.H2SO4 = 909.06 20mg QQ客服:1457312923
    长春碱; Vinblastine CFN90230 865-21-4 C46H58N4O9 = 810.96 20mg QQ客服:3257982914
    脱水长春碱; 3',4'-Anhydrovinblastine CFN90246 38390-45-3 C46H56N4O8 = 792.96 5mg QQ客服:2056216494
    硫酸长春新碱; Vincristine sulfate CFN90400 2068-78-2 C46H58N4O14S = 923.04 20mg QQ客服:1457312923
    长春瑞滨; Vinorelbine CFN90401 71486-22-1 C45H54N4O8 = 778.93 20mg QQ客服:2056216494
    长春地辛; Vindesine CFN90465 53643-48-4 C43H55N5O7 = 753.92 5mg QQ客服:2159513211
    环氧长春碱,长春素; Vinleurosine CFN90466 23360-92-1 C46H56N4O9 = 808.95 5mg QQ客服:215959384
    长春新碱; Vincristine CFN98589 57-22-7 C46H56N4O10 = 824.96 20mg QQ客服:2159513211

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