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  • 藜芦胺

    Veratramine

    藜芦胺
    产品编号 CFN90929
    CAS编号 60-70-8
    分子式 = 分子量 C27H39NO2 = 409.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Veratrum nigrum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    藜芦胺 CFN90929 60-70-8 10mg QQ客服:1457312923
    藜芦胺 CFN90929 60-70-8 20mg QQ客服:1457312923
    藜芦胺 CFN90929 60-70-8 50mg QQ客服:1457312923
    藜芦胺 CFN90929 60-70-8 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • University of Dicle (Turkey)
  • Charles University in Prague (Czech Republic)
  • Medizinische Universit?t Wien (Austria)
  • Yale University (USA)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Mendel University in Brno (Czech Republic)
  • Universiti Malaysia Pahang (Malaysia)
  • University of Wollongong (Australia)
  • University of Brasilia (Brazil)
  • Sri Ramachandra University (India)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Medicine and Pharmacy (Romania)
  • University of Minnesota (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Appl. Sci. 2021, 11(22), 10552
  • Bulletin of Health Research2016, 44(4):279-286
  • J Nat Med.2022, 76(1):59-67.
  • Int Immunopharmacol.2019, 71:361-371
  • Bioorg Med Chem.2020, 28(12):115553.
  • Research Square2021, 10.21203.
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Inflammation.2015, 38(4):1502-16
  • Sci Rep.2019, 9:12132
  • Phytomedicine.2018, 41:62-66
  • Foods.2021, 10(12):2929.
  • Front Pharmacol.2020, 11:566490.
  • Journal of Food Composition and Analysis2021, 100:103905.
  • Plants (Basel).2021, 10(6):1119.
  • Metabolites.2020, 11(1):E11.
  • Antioxidants (Basel).2020, 9(2):E120
  • Food Analytical Methods2017, 10:3225-3234
  • Int J Mol Sci.2017, 18(5)
  • Cytotechnology.2017, 69(5):765-773
  • Neuropharmacology.2018, 131:68-82
  • Int J Cosmet Sci.2023, 45(2):155-165.
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):1-20.
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • ...
  • 生物活性
    Description: Veratramine exhibits cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249. Veratramine shows hypotensive effect, the effect is directly positively correlated with the dosage.
    In vitro:
    Phytother Res. 2008 Aug;22(8):1093-6.
    Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum.[Pubmed: 18570211 ]

    METHODS AND RESULTS:
    The antitumor activity of six extracts (ethanol extract, petroleum ether fraction, CHCl(3) fraction, ethyl acetate fraction, n-butanol fraction and total alkaloids) from the rhizomes of Veratrum dahuricum, and six compounds (veratramine (1), jervine (2), germine (3), veramitaline (4), veratrosine (5) and cyclopamine (6)) from the ethanol extract were investigated in vitro. The 12 samples exhibited cytotoxic activity against human tumor cell lines A549, PANC-1, SW1990 and NCI-H249.
    CONCLUSIONS:
    Among these samples, CHCl(3) fraction, the total alkaloids, compounds 1 and 6 showed higher inhibitory activity, compound 3 selectively exhibited significant cytotoxicity to SW1990 and NCI-H249.
    In vivo:
    Pharmazie. 2008 Aug;63(8):606-10.
    Hypotensive effect and toxicology of total alkaloids and veratramine from roots and rhizomes of Veratrum nigrum L. in spontaneously hypertensive rats.[Pubmed: 18771011]

    METHODS AND RESULTS:
    Total alkaloids (VTA) and veratramine of Veratrum nigrum L. were tested for hypotensive effect using spontaneously hypertensive rats (SHR). Acute toxicities were also evaluated. There was a dose-dependent reduction in blood pressure and heart rate after a single ingestion (1.0 to 4.0 mg/kg, intragastric administration) of VTA. A single oral ingestion (0.56 to 2.24 mg/kg) of veratramine, the major component of VTA, dose-dependently decreased blood pressure and heart rate, suggesting that veratramine was involved in the hypotensive effect of VTA in SHR.
    CONCLUSIONS:
    The hypotensive effects of VTA and veratramine are directly positively correlated with the dosage. Side effects were not obvious.
    AAPS J. 2016 Mar;18(2):432-44.
    Gender-Dependent Pharmacokinetics of Veratramine in Rats: In Vivo and In Vitro Evidence.[Pubmed: 26791530]
    Veratramine, a major alkaloid from Veratrum nigrum L., has distinct anti-tumor and anti-hypertension effects. Our previous study indicated that veratramine had severe toxicity toward male rats.
    METHODS AND RESULTS:
    In order to elucidate the underling mechanism, in vivo pharmacokinetic experiments and in vitro mechanistic studies have been conducted. Veratramine was administrated to male and female rats intravenously via the jugular vein at a dose of 50 μg/kg or orally via gavage at 20 mg/kg. As a result, significant pharmacokinetic differences were observed between male and female rats after oral administration with much lower concentrations of veratramine and 7-hydroxyl-veratramine and higher concentrations of veratramine-3-O-sulfate found in the plasma and urine of female rats. The absolute bioavailability of veratramine was 0.9% in female rats and 22.5% in male rats. Further experiments of veratramine on Caco-2 cell monolayer model and in vitro incubation with GI content or rat intestinal subcellular fractions demonstrated that its efficient passive diffusion mediated absorption with minimal intestinal metabolism, suggesting no gender-related difference during its absorption process. When veratramine was incubated with male or female rat liver microsomes/cytosols, significant male-predominant formation of 7-hydroxyl-veratramine and female-predominant formation of veratramine-3-O-sulfate were observed.
    CONCLUSIONS:
    In conclusion, the significant gender-dependent hepatic metabolism of veratramine could be the major contributor to its gender-dependent pharmacokinetics.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4414 mL 12.207 mL 24.4141 mL 48.8281 mL 61.0352 mL
    5 mM 0.4883 mL 2.4414 mL 4.8828 mL 9.7656 mL 12.207 mL
    10 mM 0.2441 mL 1.2207 mL 2.4414 mL 4.8828 mL 6.1035 mL
    50 mM 0.0488 mL 0.2441 mL 0.4883 mL 0.9766 mL 1.2207 mL
    100 mM 0.0244 mL 0.1221 mL 0.2441 mL 0.4883 mL 0.6104 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    澳洲茄胺; 澳州茄胺; Solasodine CFN90200 126-17-0 C27H43NO2 = 413.62 20mg QQ客服:215959384
    澳洲茄碱; Solasonine CFN90156 19121-58-5 C45H73NO16 = 884.06 20mg QQ客服:2056216494
    澳洲茄边碱; Solamargine CFN90159 20311-51-7 C45H73NO15 = 868.06 20mg QQ客服:3257982914
    beta-澳洲茄边碱; Khasianine CFN90387 32449-98-2 C39H63NO11 = 721.93 20mg QQ客服:1457312923
    Beta-茄边碱; Beta-Solamarine CFN90552 3671-38-3 C45H73NO15 = 868.07 5mg QQ客服:3257982914
    澳茄新碱; Solasurine CFN90553 27028-76-8 C39H63NO11 = 721.92 5mg QQ客服:2159513211
    澳洲边茄碱; Solamarine CFN93102 20318-30-3 C45H73NO16 = 884.1 5mg QQ客服:2056216494
    番茄碱苷; Tomatine CFN90930 17406-45-0 C50H83NO21 = 1034.2 20mg QQ客服:1457312923
    垂茄啶; Demissidine CFN70371 474-08-8 C27H45NO = 399.7 5mg QQ客服:1457312923
    茄啶; Solanidine CFN70454 80-78-4 C27H43NO = 397.6 5mg QQ客服:215959384

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