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  • 蔚瑞昆森

    Veraguensin

    蔚瑞昆森
    产品编号 CFN00451
    CAS编号 19950-55-1
    分子式 = 分子量 C22H28O5 = 372.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The rhizomes of Acorus tatarinowii
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蔚瑞昆森 CFN00451 19950-55-1 1mg QQ客服:2159513211
    蔚瑞昆森 CFN00451 19950-55-1 5mg QQ客服:2159513211
    蔚瑞昆森 CFN00451 19950-55-1 10mg QQ客服:2159513211
    蔚瑞昆森 CFN00451 19950-55-1 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Goias (UFG) (Brazil)
  • Srinakharinwirot University (Thailand)
  • University of British Columbia (Canada)
  • Kyung Hee University (Korea)
  • University of Parma (Italy)
  • University of Stirling (United Kingdom)
  • Florida International University (USA)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Eastern Finland (Finland)
  • Osmania University (India)
  • University Medical Center Mainz (Germany)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Universidad Miguel Hernández (Spain)
  • University of Limpopo (South Africa)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2022, 23(10):5468.
  • Antioxidants (Basel).2022, 11(12):2411.
  • J Nat Prod.2022, 85(5):1351-1362.
  • Appl. Sci.2020, 10(23), 8729
  • Hum Exp Toxicol.2023, 42:9603271221145386.
  • Int J Mol Med.2019, 43(6):2516-2522
  • Journal of Functional Foods2022, 99: 105331.
  • Pharm Biol.2016, 54(7):1255-62
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Molecules.2019, 24(7):E1290
  • Phytomedicine.2022, 96:153877.
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • FASEB J.2022, 36(7):e22387.
  • J Sep Sci.2022, 45(18):3556-3566.
  • J. Korean Wood Sci. Technol.2022, 50(5):338-352.
  • Food Chem.2023, 404(Pt A):134517.
  • Applied Biological Chemistry2023, 66:42.
  • J Nat Med.2022, 76(1):59-67.
  • J Ethnopharmacol.2017, 206:73-77
  • Industrial Crops and Products2022, 188:115596.
  • Molecules.2022, 27(7):2360.
  • Phytomedicine.2019, 58:152893
  • Horticulturae2021, 7(1),5.
  • ...
  • 生物活性
    Description: Veraguensin shows activity against trypomastigote T. cruzi., it shows high antileishmanial activity. Veraguensin and galgravin can inhibit bone resorption and may offer novel compounds for the development of drugs to treat bone-destructive diseases such as osteoporosis.
    Targets: NF-kB | p38MAPK | Antifection
    In vitro:
    Eur J Med Chem. 2017 Mar 10;128:25-35.
    Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis.[Pubmed: 28152426 ]
    Chagas disease and leishmaniasis are neglected tropical diseases (NTDs) endemic in developing countries. Although there are drugs available for their treatment, efforts on finding new efficacious therapies are continuous.
    METHODS AND RESULTS:
    The natural lignans grandisin (1) and Veraguensin (2) show activity against trypomastigote T. cruzi and their scaffold has been used as inspiration to design new derivatives with improved potency and chemical properties. We describe here the planning and microwave-irradiated synthesis of 26 isoxazole derivatives based on the structure of the lignans 1 and 2. In addition, the in vitro evaluation against culture trypomastigotes and intracellular amastigotes of T. cruzi and intracellular amastigotes of L. amazonensis and L. infantum is reported.
    CONCLUSIONS:
    Among the synthesized derivatives, compounds 17 (IC50 = 5.26 μM for T. cruzi), 29 (IC50 = 1.74 μM for T. cruzi) and 31 (IC50 = 1.13 μM for T. cruzi and IC50 = 5.08 μM for L. amazonensis) were the most active and were also evaluated against recombinant trypanothione reductase of T. cruzi in a preliminary study of their mechanism of action.
    Phytother Res. 2008 Oct;22(10):1307-10.
    In vitro antileishmanial and antimalarial activities of tetrahydrofuran lignans isolated from Nectandra megapotamica (Lauraceae).[Pubmed: 18688887 ]
    Seven tetrahydrofuran lignans, isolated from Nectandra megapotamica (Lauraceae), were evaluated for their in vitro antileishmanial and antimalarial activities.
    METHODS AND RESULTS:
    Among the evaluated compounds, machilin-G (1a) and Veraguensin (2a) showed the highest antileishmanial activities, displaying for both compounds an IC(50) value of 18 microg/mL and an IC(90) value of 36 microg/mL, while galgravin (1b), nectandrin-A (1c), nectandrin-B (1d), calopeptin (2b) and ganshisandrine (3) were inactive against Leishmania donovani. In the antimalarial assay against Plasmodium falciparum, it was observed that calopeptin (2b) displayed moderate activity, with IC(50) values of 3800 ng/mL (D6 clone) and 3900 ng/mL (W2 clone), while the lignans 1a-1d, 2a and 3 were inactive.
    CONCLUSIONS:
    In order to compare the effect on the parasites with toxicity to mammalian cells, the cytotoxic activity of the isolated compounds were evaluated against the Vero cells, showing that all evaluated tetrahydrofuran lignans exhibited no cytotoxicity at the maximum dose tested.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6846 mL 13.4228 mL 26.8456 mL 53.6913 mL 67.1141 mL
    5 mM 0.5369 mL 2.6846 mL 5.3691 mL 10.7383 mL 13.4228 mL
    10 mM 0.2685 mL 1.3423 mL 2.6846 mL 5.3691 mL 6.7114 mL
    50 mM 0.0537 mL 0.2685 mL 0.5369 mL 1.0738 mL 1.3423 mL
    100 mM 0.0268 mL 0.1342 mL 0.2685 mL 0.5369 mL 0.6711 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    襄五脂素; Chicanine CFN90914 78919-28-5 C20H22O5 = 342.39 5mg QQ客服:2056216494
    Futokadsurin C ; Futokadsurin C CFN96728 852459-91-7 C21H24O5 = 356.41 5mg QQ客服:1457312923
    (7S,7'R)-双(3,4-亚甲二氧苯基)-rel-(8R,8'R)-二甲基四氢呋喃; rel-(8R,8'R)-dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan CFN90655 178740-32-4 C20H20O5 = 340.4 20mg QQ客服:1457312923
    翼梗五味子木脂素; Henricine CFN95244 107783-46-0 C22H26O6 = 386.4 5mg QQ客服:1413575084
    (-)-di-de-O-methylgrandisin; (-)-di-de-O-methylgrandisin CFN92890 50393-98-1 C22H28O7 = 404.45 5mg QQ客服:215959384
    Foliachinenoside C; Foliachinenoside C CFN95361 1041180-87-3 C28H38O14 = 598.6 5mg QQ客服:1457312923
    绿皮黄筋竹二聚物A; Phyllostadimer A CFN97098 638203-32-4 C42H50O16 = 810.9 5mg QQ客服:3257982914
    9-O-乙酰基-4,4'-二-O-甲基落叶松树脂醇; 9-O-Acetyl-4,4'-di-O-methyllariciresinol CFN97216 73354-15-1 C24H30O7 = 430.5 5mg QQ客服:1457312923
    肉豆蔻素A2; Fragransin A2 CFN99225 112652-46-7 C20H24O5 = 344.4 5mg QQ客服:2056216494
    肉豆蔻素B1; Fragransin B1 CFN95443 112516-03-7 C22H28O7 = 404.5 5mg QQ客服:1457312923

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