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  • 毡毛美洲茶素

    Velutin

    毡毛美洲茶素
    产品编号 CFN98290
    CAS编号 25739-41-7
    分子式 = 分子量 C17H14O6 = 314.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Vernonia flexuosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    毡毛美洲茶素 CFN98290 25739-41-7 1mg QQ客服:215959384
    毡毛美洲茶素 CFN98290 25739-41-7 5mg QQ客服:215959384
    毡毛美洲茶素 CFN98290 25739-41-7 10mg QQ客服:215959384
    毡毛美洲茶素 CFN98290 25739-41-7 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Mendel University in Brno (Czech Republic)
  • Heidelberg University (Germany)
  • Almansora University (Egypt)
  • Agricultural Research Organization (ARO) (Israel)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Medizinische Universit?t Wien (Austria)
  • Georgia Institute of Technology (USA)
  • University of Indonesia (Indonesia)
  • CSIRO - Agriculture Flagship (Australia)
  • Chinese University of Hong Kong (China)
  • University of Virginia (USA)
  • Pennsylvania State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem Toxicol.2023, 176:113785.
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • Korean Herb. Med. Inf.2020, 8(2):205-213
  • Food Res Int.2021, 148:110607.
  • Molecules.2020, 25(3):734
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Br J Pharmacol.2016, 173(2):396-410
  • J Nat Med.2017, 71(4):745-756
  • Chem Res Toxicol.2023, 36(2):213-229.
  • J Med Food.2019, 22(10):1067-1077
  • Foods.2023, 12(12):2412.
  • TCI CO.2019, US20190151257A1
  • Front Nutr.2021, 8: 687851.
  • Food Science and Biotechnology2023, 2023:1007
  • Cell Death Dis.2019, 10(12):882
  • Chem Biodivers.2023, 20(10):e202300741.
  • Plant Archives2020, 2(1),2929-2934
  • Research Square2023, 2883170.
  • Phytother Res.2018, 32(5):923-932
  • Korean J. Food Preserv.2023, 30(4):663-668.
  • Appl. Sci. 2021, 11(22),10569
  • Chem Biol Interact.2016, 258:59-68
  • ...
  • 生物活性
    Description: Velutin has strong anti-inflammatory activity, it can effectively inhibit the expression of proinflammatory cytokines TNF-α and IL-6 in low micromole levels by inhibiting NF-κB activation and p38 and JNK phosphorylation. Velutin controls HIF-1α activity during PgLPS-activated osteoclastogenesis probably through modulation of the NF-κB pathway, perhaps it could be used therapeutically to prevent bone loss seen in periodontitis.Velutin can induce apoptosis in tumor cells.
    Targets: TNF-α | IL Receptor | NF-kB | p38MAPK | JNK | HIF | IkB | IKK
    In vitro:
    J Nutr Biochem. 2012 Sep;23(9):1184-91.
    The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway.[Pubmed: 22137267]
    Recent studies have shown that some flavonoids are modulators of proinflammatory cytokine production.
    METHODS AND RESULTS:
    In this study, velutin, a unique flavone isolated from the pulp of açaí fruit (Euterpe oleracea Mart.), was examined for its effects in reducing lipopolysaccharide-induced proinflammatory cytokine tumor necrosis factor (TNF)-α and interleukin (IL)-6 production in RAW 264.7 peripheral macrophages and mice peritoneal macrophages. Three other structurally similar and well-studied flavones, luteolin, apigenin and chrysoeriol, were included as controls and for comparative purposes. Velutin exhibited the greatest potency among all flavones in reducing TNF-α and IL-6 production. Velutin also showed the strongest inhibitory effect in nuclear factor (NF)-κB activation (as assessed by secreted alkaline phosphatase reporter assay) and exhibited the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation; all of these are important signaling pathways involved in production of TNF-α and IL-6.
    CONCLUSIONS:
    The present study led to the discovery of a strong anti-inflammatory flavone, velutin. This compound effectively inhibited the expression of proinflammatory cytokines TNF-α and IL-6 in low micromole levels by inhibiting NF-κB activation and p38 and JNK phosphorylation.
    Toxicol In Vitro. 2010 Jun;24(4):1250-7.
    Differential abilities of the mushroom ribosome-inactivating proteins hypsin and velutin to perturb normal development of cultured mouse embryos.[Pubmed: 20149862]
    The teratogenicity of two fungal ribosome-inactivating proteins, hypsin from Hypsizigus mamoreus and velutin from Flammulina velutipes, was examined in this investigation using microinjection and postimplantation whole-embryo culture.
    METHODS AND RESULTS:
    The results demonstrated that hypsin induced abnormal embryonic development at 2.5 microM during the organogenesis period from E8.5 to E9.5. As its dosage increased, there was an increase in the total number of abnormal embryos, a drop in the final somite number, and a rise of abnormal structures. Structural abnormalities were detected: open cranial neural tube, abnormal branchial arches, absence of forelimb buds and twisted body axis. The otic and optic placodes were, however, less affected.
    CONCLUSIONS:
    Histological study of the abnormal embryos revealed a correlation of increased cell death with abnormal structures, suggesting that induction of cell death by hypsin may account for its teratogenicity. In contrast, velutin did not exert any adverse influence on mouse development.
    Yoo Y C, Lee K B. Korea Society of Laboratory Animals, 2003,6: 101-101.
    Velutin and betulinic acid isolated from Korean mistletoe induce apoptosis in tumor cells[Reference: WebLink]
    Velutin and betulinic acid isolated from Korean mistletoe induce apoptosis in tumor cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1817 mL 15.9084 mL 31.8167 mL 63.6335 mL 79.5418 mL
    5 mM 0.6363 mL 3.1817 mL 6.3633 mL 12.7267 mL 15.9084 mL
    10 mM 0.3182 mL 1.5908 mL 3.1817 mL 6.3633 mL 7.9542 mL
    50 mM 0.0636 mL 0.3182 mL 0.6363 mL 1.2727 mL 1.5908 mL
    100 mM 0.0318 mL 0.1591 mL 0.3182 mL 0.6363 mL 0.7954 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异泽兰黄素; 泽兰林素; Eupatilin CFN90190 22368-21-4 C18H16O7 = 344.31 20mg QQ客服:3257982914
    5-去甲基甜橙黄酮; 5-Demethylsinensetin CFN95415 21763-80-4 C19H18O7 = 358.34 10mg QQ客服:215959384
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮; Sinensetin CFN99599 2306-27-6 C20H20O7 = 372.37 20mg QQ客服:2159513211
    异橙黄酮; Isosinensetin CFN90806 17290-70-9 C20H20O7 = 372.4 20mg QQ客服:1413575084
    去甲基川陈皮素; 5-O-Demethylnobiletin CFN90921 2174-59-6 C20H20O8 = 388.4 20mg QQ客服:215959384
    川陈皮素; 蜜橘黄素; 川皮亭; Nobiletin CFN98726 478-01-3 C21H22O8 = 402.4 20mg QQ客服:2056216494
    3,5,6,7,8,4'-六甲氧基黄酮; 3,5,6,7,8,4'-hexamethoxyflavone CFN91805 34170-18-8 C21H22O8 = 402.4 5mg QQ客服:1457312923
    3,3',4',5,6,7,8-七甲氧基黄酮; 3,3',4',5,6,7,8-heptamethoxyflavone CFN95021 1178-24-1 C22H24O9 = 432.4 10mg QQ客服:2159513211
    4'-羟基黄烷酮; 4'-Hydroxyflavone CFN91544 4143-63-9 C15H10O3 = 238.2 20mg QQ客服:215959384
    4'-甲氧基黄酮; 4'-Methoxyflavone CFN70361 4143-74-2 C16H12O3 = 252.3 5mg QQ客服:3257982914

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