(-)-Variabilin

	产品编号	CFN97945
	CAS编号	370102-93-5
	分子式 = 分子量	C₁₇H₁₆O₅ = 300.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The roots of Angelica sinensis
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
(-)-Variabilin	CFN97945	370102-93-5	1mg	QQ客服：3257982914
(-)-Variabilin	CFN97945	370102-93-5	5mg	QQ客服：3257982914
(-)-Variabilin	CFN97945	370102-93-5	10mg	QQ客服：3257982914
(-)-Variabilin	CFN97945	370102-93-5	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

National Hellenic Research Foundation (Greece)

Universidad Industrial de Santander (Colombia)

Mendel University in Brno (Czech Republic)

Universidade Federal de Santa Catarina (Brazil)

University of Maryland (USA)

S.N.D.T. Women's University (India)

Tokyo Woman's Christian University (Japan)

Subang Jaya Medical Centre (Malaysia)

Sant Gadge Baba Amravati University (India)

University of Otago (New Zealand)

Istanbul University (Turkey)

The Vancouver Prostate Centre (VPC) (Canada)

Universidad de Antioquia (Colombia)

Universite Libre de Bruxelles (Belgium)

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Description:

Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro and shows anti-inflammatory activity after topical or p.o. administration to mice.

Targets:

Phospholipase (e.g. PLA) | Immunology & Inflammation related

In vitro:

J. Biol. Chem., 1996, 271(30):17785-90.

Variabilin, a Novel RGD-containing Antagonist of Glycoprotein IIb-IIIa and Platelet Aggregation Inhibitor from the Hard Tick Dermacentor variabilis*[Reference: WebLink]

METHODS AND RESULTS:
A novel inhibitor of human platelet aggregation, named variabilin, was isolated from salivary glands of the hard tick Dermacentor variabilis using a combination of gel filtration and high pressure liquid chromatography. Variabilin was a potent antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3. Amino acid sequence analysis by Edman degradation revealed that it has 47 residues, with a molecular weight of 4968.5. Like many other naturally occurring antagonists of GPIIb-IIIa, variabilin contains the RGD (Arg-Gly-Asp) motif. However, unlike the RGD-containing antagonists of GPIIb-IIIa, the RGD sequence of variabilin is not positioned in a loop bracketed by cysteine residues.
CONCLUSIONS:
It has little sequence homology to the other known naturally occurring antagonists of GPIIb-IIIa, including the disintegrins from snakes, decorsin and ornatin from leeches, and disagregin from soft ticks. Variabilin is the first RGD-containing antagonist isolated from ticks.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
红车轴草根甙；三叶豆紫檀苷; Trifolirhizin	CFN97160	6807-83-6	C₂₂H₂₂O₁₀ = 446.4	20mg	QQ客服：2159513211
6alpha-羟基高丽槐素; 6alpha-Hydroxymaackiain	CFN96037	61218-44-8	C₁₆H₁₂O₆ = 300.3	5mg	QQ客服：1413575084
豌豆素; Pisatin	CFN96000	20186-22-5	C₁₇H₁₄O₆ = 314.3	5mg	QQ客服：1457312923
Sophoracarpan A ; Sophoracarpan A	CFN96672	1674359-82-0	C₁₇H₁₆O₅ = 300.31	5mg	QQ客服：2056216494
Sophoracarpan B ; Sophoracarpan B	CFN96671	1674359-84-2	C₁₇H₁₄O₆ = 314.30	5mg	QQ客服：1413575084
Meliotocarpan D; Meliotocarpan D	CFN95401	83013-81-4	C₁₇H₁₆O₆ = 316.3	5mg	QQ客服：2159513211
1,11B-二氢-11B-羟基美迪紫檀素; 1,11b-Dihydro-11b-hydroxymedicarpin	CFN96002	210537-04-5	C₁₆H₁₆O₅ = 288.3	5mg	QQ客服：215959384
1,11B-二氢-11B-羟基高丽槐素; 1,11b-Dihydro-11b-hydroxymaackiain	CFN96003	210537-05-6	C₁₆H₁₄O₆ = 302.3	5mg	QQ客服：215959384
Pterocarpadiol D; Pterocarpadiol D	CFN89484	2055882-23-8	C₁₆H₁₆O₆ = 304.29	5mg	QQ客服：2056216494
Pterocarpadiol C; Pterocarpadiol C	CFN89483	2055882-22-7	C₁₆H₁₄O₇ = 318.27	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.33 mL	16.65 mL	33.3 mL	66.6001 mL	83.2501 mL
5 mM	0.666 mL	3.33 mL	6.66 mL	13.32 mL	16.65 mL
10 mM	0.333 mL	1.665 mL	3.33 mL	6.66 mL	8.325 mL
50 mM	0.0666 mL	0.333 mL	0.666 mL	1.332 mL	1.665 mL
100 mM	0.0333 mL	0.1665 mL	0.333 mL	0.666 mL	0.8325 mL