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  • 5-甲氧基莨菪亭

    Umckalin

    5-甲氧基莨菪亭
    产品编号 CFN70362
    CAS编号 43053-62-9
    分子式 = 分子量 C11H10O5 = 222.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Pelargonium reniforme
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5-甲氧基莨菪亭 CFN70362 43053-62-9 1mg QQ客服:215959384
    5-甲氧基莨菪亭 CFN70362 43053-62-9 5mg QQ客服:215959384
    5-甲氧基莨菪亭 CFN70362 43053-62-9 10mg QQ客服:215959384
    5-甲氧基莨菪亭 CFN70362 43053-62-9 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Hull (United Kingdom)
  • University of Pretoria (South Africa)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • University of the Basque Country (Spain)
  • Florida International University (USA)
  • Ain Shams University (Egypt)
  • Agricultural Research Organization (ARO) (Israel)
  • Korea Food Research Institute(KFRI) (Korea)
  • John Innes Centre (United Kingdom)
  • University of Virginia (USA)
  • National Cancer Center Research Institute (Japan)
  • Universidad de La Salle (Mexico)
  • Imperial College London (United Kingdom)
  • University Medical Center Mainz (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J of l. Chroma.&Related Tech2020, 43(11-12):414-423.
  • J Plant Biotechnol.2023, 50:070-075.
  • J Mol Recognit.2020, 33(2):e2819
  • Chem. of Vegetable Raw Materials2020, 97-105
  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • Metabolites.2020, 10(11):440.
  • Metabolites.2023, 13(5):625.
  • Molecules.2019, 24(16):E2985
  • Int J Mol Sci.2019, 20(16):E4015
  • Molecules.2022, 27(19):6651.
  • Front Pharmacol.2018, 9:236
  • Heliyon.2022, e12337.
  • Int J Biol Macromol.2021, 199:189-200.
  • J Clin Med.2019, 8(10):E1664
  • UDC.2020, 19(4).
  • Semyung University2017, 149407
  • Sci Rep.2019, 9:19059
  • ACS Omega.2022, 7(44):40009-40020.
  • Acta Edulis Fungi2020, 27(02):63-76.
  • Int J Mol Sci.2020, 21(19),7070.
  • Integr Med Res.2017, 6(4):395-403
  • Front Microbiol.2023, 14:1232039.
  • Journal of Ginseng Research2021, 3 June.
  • ...
  • 生物活性
    Description: Umckalin shows antibacterial activity. Umckalin has antitubercular activity, it exhibited MIC values of 62.5 µg/mL against M. smegmatis.
    Targets: Antifection
    In vitro:
    Phytotherapy Research 22(6):841-845.
    Antitubercular Activity of Compounds Isolated from Pelargonium sidoides.[Reference: WebLink]
    The recent increase in the incidence of tuberculosis with the emergence of multidrug-resistant (MDR) cases has lead to the search for new drugs that are effective against MDR strains of Mycobacterium tuberculosis. and can augment the potential of existing drugs against tuberculosis.
    METHODS AND RESULTS:
    Pelargonium sidoides. DC (Geraniaceae) is highly valued by traditional healers for its curative properties and is well-known to treat coughs, diarrhea, and tuberculosis. The butanol root extract was found have bioactive inhibitory activity against M. tuberculosis. at a concentration of 2.5 × 103 µg/mL. Phytochemical analysis of the active fraction from the root of P. sidoides. led to the isolation and identification of six compounds: coumarins (umckalin, scopoletin, 6,8-dihydroxy-5.7-dimethoxy-2H.-benzopyran-2-one, and 6,8-dihydroxy-7-methoxy-2H.-benzopyran-2-one) and flavonoids (catechin and epigallocatechin, which is reported for the first time from P. sidoides.). The isolated compounds were evaluated for antitubercular activity with M. smegmatis. and M. tuberculosis.. Intracellular activity of these compounds was also investigated using THP-1 human macrophages infected with M. tuberculosis..
    CONCLUSIONS:
    The isolated compounds did not show activity inhibitory against M. tuberculosis., intracellularly and extracellularly, at the highest concentration tested in the current study. Epigallocatechin and scopoletin showed good inhibitory activity against M. smegmatis., exhibiting a minimum inhibitory concentration (MIC) of 7.8 µg/mL. Catechin and umckalin exhibited MIC values of 31.25 and 62.5 µg/mL, respectively.
    Planta Medica, 1998, 63(6):508-510.
    Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme.[Reference: WebLink]

    METHODS AND RESULTS:
    The antibacterial activity of extracts and isolated constituents (scopoletin, umckalin, 5,6,7-trimethoxycoumarin, 6,8-dihydroxy-5,7-dimethoxycoumarin, (+)-catechin, gallic acid and its methyl ester) of Pelargonium sidoides and Pelargonium reniforme (Geraniaceae), plant species used in folk medicine by the Southern African native population, was evaluated against 8 microorganisms, including 3 Gram-positive (Staphylococcus aureus, Streptococcus pneumoniae, and beta-hemolytic Streptococcus 1451) and 5 Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Haemophilus influenzae).
    CONCLUSIONS:
    Minimum inhibitory concentrations (MICs) varied with the preparation of the extracts and microorganisms tested, from about 0.6 mg/ml for aqueous phases to over 10 mg/ml for crude Pelargonium extracts. With the exception of the ineffective (+)-catechin, all the potentially active compounds exhibited antibacterial activities with MICs of 200-1000 micrograms/ml. The results provide for a rational basis of the traditional use of the titled Pelargonium species.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5005 mL 22.5023 mL 45.0045 mL 90.009 mL 112.5113 mL
    5 mM 0.9001 mL 4.5005 mL 9.0009 mL 18.0018 mL 22.5023 mL
    10 mM 0.45 mL 2.2502 mL 4.5005 mL 9.0009 mL 11.2511 mL
    50 mM 0.09 mL 0.45 mL 0.9001 mL 1.8002 mL 2.2502 mL
    100 mM 0.045 mL 0.225 mL 0.45 mL 0.9001 mL 1.1251 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    白蜡树精; Fraxinol CFN98768 486-28-2 C11H10O5 = 222.2 5mg QQ客服:215959384
    5-甲氧基莨菪亭; Umckalin CFN70362 43053-62-9 C11H10O5 = 222.2 5mg QQ客服:1413575084
    5-羟基-6,7-二甲氧基香豆素; Tomentin CFN98347 28449-62-9 C11H10O5 = 222.2 5mg QQ客服:1413575084
    5,6,7-三甲氧基香豆素; 5,6,7-Trimethoxycoumarin CFN89309 55085-47-7 C12H12O5 = 236.22 5mg QQ客服:2056216494
    5-羟基-6,7,8-甲氧基香豆素; 5-Hydroxy-6,7,8-trimethoxycoumarin CFN89182 1581248-32-9 C12H12O6 = 252.22 5mg QQ客服:3257982914
    5,6,7,8-四甲氧基香豆素; 5,6,7,8-Tetramethoxycoumarin CFN98941 56317-15-8 C13H14O6 = 266.3 5mg QQ客服:2056216494
    8-乙酰基-7-羟基香豆素; 8-Acetyl-7-hydroxycoumarin CFN70438 6748-68-1 C11H8O4 = 204.2 5mg QQ客服:1413575084
    8-乙酰基-7-甲氧基香豆素; 8-Acetyl-7-methoxycoumarin CFN70467 89019-07-8 C12H10O4 = 218.2 5mg QQ客服:215959384
    5,7,8-三甲氧基香豆素; 5,7,8-Trimethoxycoumarin CFN97036 60796-65-8 C12H12O5 = 236.2 5mg QQ客服:2159513211
    Artanin; Artanin CFN97547 96917-26-9 C16H18O5 = 290.3 5mg QQ客服:215959384

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