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  • 曲克芦丁

    Troxerutin

    曲克芦丁
    产品编号 CFN93196
    CAS编号 7085-55-4
    分子式 = 分子量 C33H42O19 = 742.7
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The fruits of Styphnolobium japonicum (L.) Schott
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    曲克芦丁 CFN93196 7085-55-4 10mg QQ客服:2056216494
    曲克芦丁 CFN93196 7085-55-4 20mg QQ客服:2056216494
    曲克芦丁 CFN93196 7085-55-4 50mg QQ客服:2056216494
    曲克芦丁 CFN93196 7085-55-4 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Macau University of Science and Technology (China)
  • University of Hertfordshire (United Kingdom)
  • Stanford University (USA)
  • CSIRO - Agriculture Flagship (Australia)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of the Basque Country (Spain)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Parma (Italy)
  • Indian Institute of Science (India)
  • The Ohio State University (USA)
  • Heidelberg University (Germany)
  • Ateneo de Manila University (Philippines)
  • Calcutta University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Cosmet Sci.2023, 45(2):155-165.
  • Plants (Basel).2020, 9(11):1555.
  • Biomed Pharmacother.2020, 125:109784.
  • BMC Complement Med Ther. 2020, 20(1):91.
  • Kasetsart University2022, ethesis.1144.
  • Molecules.2022, 27(22):7997.
  • Nutrients.2018, 10(10)
  • University of Central Lancashire2017, 20472
  • BMC Microbiol.2019, 19(1):78
  • BMC Complement Altern Med.2019, 19(1):339
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • South African J of Plant&Soil2018, 29-32
  • Data Science for Genomics2023, 107-128.
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Appl. Sci. 2021, 11(1),14.
  • J Food Sci.2021, 86(9):3810-3823.
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Antioxidants (Basel).2020, 9(6):526.
  • Separations2021, 8(7),90.
  • Biomed Sci Letters.2020, 26:319-326
  • Chin Med.2022, 17(1):66.
  • Food Research2022, 6(6): 30-38.
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • ...
  • 生物活性
    Description: Troxerutin protects against high cholesterol-induced cognitive deficits in mice, it could be recommended as a possible candidate for the prevention and therapy of cognitive deficits in type 2 diabetes mellitus and Alzheimer's disease. Troxerutin can attenuate renal injury induced by D-galactose probably through its antioxidant and anti-inflammation properties, it also has efficacy on streptozotocin-induced rat model in the early stage of diabetic retinopathy.
    Targets: VEGFR | Wnt/β-catenin | NF-kB | SOD | PI3K | Akt
    In vivo:
    Arzneimittelforschung. 2005;55(10):573-80.
    Efficacy of troxerutin on streptozotocin-induced rat model in the early stage of diabetic retinopathy.[Pubmed: 16294503 ]
    The vascular changes associated with early diabetic retinopathy, which include the formation of microaneurysms and acellular capillaries, vessel dilation, vascular endothelial growth factor expression, were investigated experimentally in streptozotocin-induced diabetic rats treated with antioxidants: Troxerutin (trihydroxy-ethylrutoside, CAS 7085-55-4), Vaccinium myrtillus, and calcium dobesilate (hydroquinone calcium sulfonate, CAS 20123-80-2).
    METHODS AND RESULTS:
    The development and progression of retinopathy was followed using fundus photography. After 3 months, the rats were sacrificed and half of the eyes were prepared for neovascularization analysis, and the other half were used for VEGF (vascular endothelial growth factor) analysis. However, there were no significant differences between the groups. The VEGF-mRNA density showed a increasing tendency by 20% in the diabetic rats compared with the non-diabetic rats (1.0 +/- 0.1 vs 1.2 +/- 0.1 VEGF/beta-actin), and this increase was corrected by 10 mg/kg Troxerutin (1.0 +/- 0.1 VEGF/beta-actin), 50 mg/kg Troxerutin (0.9 +/- 0.1 VEGF/beta-actin) and Vaccinium myrtillus (1.1 +/- 0.1 VEGF/beta-actin). Oxidative stress might be involved in the upregulation of retinal VEGF during early diabetes, and it is likely that Troxerutin has comparatively effective antioxidant properties.
    CONCLUSIONS:
    Therefore, Troxerutin might be a useful treatment for attenuating diabetic retinopathy.
    Brain. 2011 Mar;134(Pt 3):783-97.
    Troxerutin protects against high cholesterol-induced cognitive deficits in mice.[Pubmed: 21252113 ]
    Recent findings suggest that neurotoxicity is the mechanism underlying the induction of neuronal insulin resistance by a high cholesterol diet. Troxerutin, a naturally occurring flavonoid, has been reported to possess biological activity beneficial to human health. Our recent studies have demonstrated that troxerutin attenuates cognitive impairment and oxidative stress induced by D-galactose in mouse brain through decreasing advanced glycation end products, reactive oxygen species and protein carbonyl levels and enhancing phosphoinositide 3-kinase/Akt activation.
    METHODS AND RESULTS:
    In this study, we evaluated the effect of troxerutin on cognitive impairment induced by brain insulin resistance in mice fed a high-cholesterol diet, and explored its potential mechanism. Our results showed that oral administration of troxerutin to these mice significantly improved behavioural performance in a step-through passive avoidance task and a Morris water maze task, at least in part, by decreasing the levels of reactive oxygen species, protein carbonyl and advanced glycation end products and blocking endoplasmic reticulum stress via reduced phosphorylation of the pancreatic endoplasmic reticulum-resident kinase and eukaryotic translation initiation factor 2α. Furthermore, troxerutin significantly inhibited the activation of c-jun N-terminal kinase 1 and IκB kinase β/nuclear factor-κB induced by endoplasmic reticulum stress and enhanced insulin signalling pathway, which prevented obesity, restored normal levels of blood glucose, fatty acids and cholesterol and increased the phosphorylation of cyclic adenosine monophosphate response element-binding protein and the expression levels of c-fos in the hippocampus. Moreover, troxerutin significantly inhibited endoplasmic reticulum stress-induced apoptosis and decreased the activation of caspase-12 and caspase-3, and reduced the mean optical density of the terminal deoxyribonucleotidyl transferase-mediated dUTP-digoxigenin nick end label-positive cells in the hippocampus. However, intra-cerebroventricular infusion of PI-103, a specific phosphoinositide 3-kinase 110α inhibitor, significantly inhibited the expression levels of phosphoinositide 3-kinase 110α and phosphoinositide 3-kinase downstream signalling in the hippocampus of mice co-treated with high cholesterol and troxerutin and vehicle control mice.
    CONCLUSIONS:
    These results suggest that troxerutin could be recommended as a possible candidate for the prevention and therapy of cognitive deficits in type 2 diabetes mellitus and Alzheimer's disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3464 mL 6.7322 mL 13.4644 mL 26.9288 mL 33.661 mL
    5 mM 0.2693 mL 1.3464 mL 2.6929 mL 5.3858 mL 6.7322 mL
    10 mM 0.1346 mL 0.6732 mL 1.3464 mL 2.6929 mL 3.3661 mL
    50 mM 0.0269 mL 0.1346 mL 0.2693 mL 0.5386 mL 0.6732 mL
    100 mM 0.0135 mL 0.0673 mL 0.1346 mL 0.2693 mL 0.3366 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黄肉楠碱; Actein CFN99864 18642-44-9 C37H56O11 = 676.9 5mg QQ客服:1413575084
    6(1H)-Azulenone, 2,3-dihydro-1,4-dimethyl; 6(1H)-Azulenone, 2,3-dihydro-1,4-dimethyl CFN92790 71305-89-0 C12H14O = 174.2 5mg QQ客服:3257982914
    Go 6983; Go 6983 CFN60112 133053-19-7 C26H26N4O3 = 442.51 5mg QQ客服:215959384
    虎皮楠生物碱A; Daphniyunnine A CFN97447 881388-87-0 C23H31NO3 = 369.5 5mg QQ客服:3257982914

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