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  • 托品酮

    Tropinone

    托品酮
    产品编号 CFN00220
    CAS编号 532-24-1
    分子式 = 分子量 C8H13NO = 139.19
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Atropa belladonna
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    托品酮 CFN00220 532-24-1 10mg QQ客服:2159513211
    托品酮 CFN00220 532-24-1 20mg QQ客服:2159513211
    托品酮 CFN00220 532-24-1 50mg QQ客服:2159513211
    托品酮 CFN00220 532-24-1 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Nanjing University of Chinese Medicine (China)
  • National Research Council of Canada (Canada)
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  • The Vancouver Prostate Centre (VPC) (Canada)
  • Aarhus University (Denmark)
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  • University of Toulouse (France)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Phytomedicine.2019, 58:152893
  • Journal of Apicultural Research2021, 60(1)
  • Processes2021, 9(11),2065.
  • Antioxidants (Basel).2020, 9(6):526.
  • J Ethnopharmacol.2022, 289:115018.
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Molecules.2022, 27(7):2116.
  • Primary and Industrial.2018, 52(11)
  • Sci Rep.2019, 9(1):6429
  • Viruses.2021, 13(11):2118.
  • J-STAGE2015, 249-255
  • Phytomedicine.2022, 110:154597.
  • Nutrients.2018, 10(10)
  • Appl. Sci.2020, 10(16),5482.
  • Toxicol In Vitro.2023, 86:105521.
  • Nat Chem Biol.2018, 14(8):760-763
  • Nutrients.2020, 12(12):3607.
  • Front Pharmacol.2022, 13:883475.
  • Environ Toxicol.2021, 36(9):1848-1856.
  • Life Sci.2021, 286:120019.
  • Anal Chim Acta.2018, 1039:162-171
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • ...
  • 生物活性
    Description: Tropinone is a decane alkaloid, used as an intermediate in the synthesis of atropine sulfate.
    In vitro:
    Bioorg Chem. 2014 Apr;53:37-49.
    Substrate flexibility and reaction specificity of tropinone reductase-like short-chain dehydrogenases.[Pubmed: 24583623]
    Annotations of protein or gene sequences from large scale sequencing projects are based on protein size, characteristic binding motifs, and conserved catalytic amino acids, but biochemical functions are often uncertain.
    METHODS AND RESULTS:
    In the large family of short-chain dehydrogenases/reductases (SDRs), functional predictions often fail. Putative tropinone reductases, named tropinone reductase-like (TRL), are SDRs annotated in many genomes of organisms that do not contain tropane alkaloids. SDRs in vitro often accept several substrates complicating functional assignments. Cochlearia officinalis, a Brassicaceae, contains tropane alkaloids, in contrast to the closely related Arabidopsis thaliana. TRLs from Arabidopsis and the tropinone reductase isolated from Cochlearia (CoTR) were investigated for their catalytic capacity. In contrast to CoTR, none of the Arabidopsis TRLs reduced tropinone in vitro. NAD(H) and NADP(H) preferences were relaxed in two TRLs, and protein homology models revealed flexibility of amino acid residues in the active site allowing binding of both cofactors. TRLs reduced various carbonyl compounds, among them terpene ketones. The reduction was stereospecific for most of TRLs investigated, and the corresponding terpene alcohol oxidation was stereoselective. Carbonyl compounds that were identified to serve as substrates were applied for modeling pharmacophores of each TRL. A database of commercially available compounds was screened using the pharmacophores. Compounds identified as potential substrates were confirmed by turnover in vitro.
    CONCLUSIONS:
    Thus pharmacophores may contribute to better predictability of biochemical functions of SDR enzymes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 7.1844 mL 35.9221 mL 71.8442 mL 143.6885 mL 179.6106 mL
    5 mM 1.4369 mL 7.1844 mL 14.3688 mL 28.7377 mL 35.9221 mL
    10 mM 0.7184 mL 3.5922 mL 7.1844 mL 14.3688 mL 17.9611 mL
    50 mM 0.1437 mL 0.7184 mL 1.4369 mL 2.8738 mL 3.5922 mL
    100 mM 0.0718 mL 0.3592 mL 0.7184 mL 1.4369 mL 1.7961 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    托品酮; Tropinone CFN00220 532-24-1 C8H13NO = 139.19 20mg QQ客服:1413575084
    6-羟基托品酮; 6-Hydroxytropinone CFN00477 5932-53-6 C8H13NO2 = 155.2 20mg QQ客服:1457312923
    Physoperuvine; Physoperuvine CFN00221 60723-27-5 C8H15NO = 141.21 5mg QQ客服:1413575084
    东莨菪醇; Scopine CFN00226 498-45-3 C8H13NO2 = 155.20 20mg QQ客服:215959384
    托品醇; 品托碱; Tropine CFN00205 120-29-6 C8H15NO = 141.21 20mg QQ客服:215959384
    乙酰托品醇; Tropine acetate CFN00206 3423-27-6 C10H17NO2 = 183.25 5mg QQ客服:2056216494
    托品醇异丁酯; Tropine isobutyrate CFN00207 495-80-7 C12H21NO2 = 211.30 5mg QQ客服:2056216494
    托品醇壬酸酯; Tropine nonanoate CFN00209 146018-90-8 C17H31NO2 = 281.44 5mg QQ客服:3257982914
    β-托品醇; Pseudotropine CFN00217 135-97-7 C8H15NO = 141.21 20mg QQ客服:3257982914
    3-乙酰莨菪烷; 3-Acetoxytropane CFN00218 3423-26-5 C10H17NO2 = 183.25 5mg QQ客服:2056216494

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