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  • Triptoquinone A

    • Triptoquinone A

    Triptoquinone A

    Triptoquinone A
    		产品编号 CFN96475
    CAS编号 142950-86-5
    分子式 = 分子量 C20H24O4 = 328.40
    产品纯度 >=98%
    物理属性 Orange powder
    化合物类型 Quinones
    植物来源 The roots of Tripterygium wilfordii Hook.f.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Triptoquinone A CFN96475 142950-86-5 1mg QQ客服：2159513211
    Triptoquinone A CFN96475 142950-86-5 5mg QQ客服：2159513211
    Triptoquinone A CFN96475 142950-86-5 10mg QQ客服：2159513211
    Triptoquinone A CFN96475 142950-86-5 20mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Universiti Malaysia Pahang (Malaysia)
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  • Julius Kühn-Institut (Germany)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int. J. Mol. Sci.2023, 24(20),15294.
  • Am J Chin Med.2016, 44(6):1255-1271
  • J Nat Prod.2023, 86(2):264-275.
  • Phytochemistry.2021, 181:112539.
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • Food and Fermentation Industries2019, 45(7):45-51
  • BMC Complement Altern Med.2019, 19(1):367
  • Antioxidants (Basel).2020, 9(2):E120
  • Pharmacognosy Journal.2022, 14,4,327-337.
  • Plant Cell Physiol.2018, 59(1):128-141
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • Exp Parasitol.2017, 183:160-166
  • Nat Commun.2021, 12(1):681.
  • J Nat Prod.2019, 82(4):1002-1008
  • Internoational J of Toxicology2020, 10.1177.
  • Antioxidants (Basel).2021, 10(10):1620.
  • University of Central Lancashire2017, 20472
  • Neurotoxicology.2022, 91:218-227.
  • Sci Rep.2023, 13(1):21690.
  • BMC Complement Altern Med.2019, 19(1):11
  • J Biomol Struct Dyn.2023, 1-21.
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  • ...
    • 生物活性
    Description: Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory activity, it prevents ndotoxin-or interleukin-1 beta-promoted induction of nitric oxide synthase in vascular smooth muscle, thus inhibiting development of L-arginine-induced vasorelaxation.
    Targets: NO | NOS | IL Receptor
    In vitro:
    Biochem Biophys Res Commun. 1996 Jul 16;224(2):579-85.
    Suppression of inducible nitric oxide synthase mRNA expression by tryptoquinone A.[Pubmed: 8702429 ]
    Triptoquinone A (TQA), which is an anti-inflammatory constituent in plants, was studied for its suppressive effect on nitric oxide production by LPS.
    METHODS AND RESULTS:
    TQA significantly suppressed smooth muscle relaxation and increase in cyclic GMP levels by nitric oxide (NO) in an L-arginine-induced relaxation experiment. The mechanistic studies showed that TQA did not directly inhibit NO radicals and inducible nitric oxide synthase (iNOS) enzyme but suppressed IL-1 beta and iNOS mRNA expression by LPS. The suppression level of iNOS gene expression by TQA was comparable to that by dexamethasone.
    CONCLUSIONS:
    TQA may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression.
    In vivo:
    Life Sci. 1996;59(3):PL49-54.
    Inhibition by triptoquinone-A of LPS- and IL-1 beta-primed induction of NO synthase in rat thoracic aorta.[Pubmed: 8699928]

    METHODS AND RESULTS:
    We investigated the effect of Triptoquinone A (TQA), an active principal of Triptergium wilfordii, on the induction of nitric oxide synthase (NOS) promoted by endotoxin (LPS) and interleukin-1 beta (IL-1 beta). Prophylactic application of TQA selectively prevented LPS-primed initiation of L-arginine (Arg)-induced relaxation, and cGMP formation of rat thoracic aorta, and LPS-stimulated nitrite production by cultured aortic smooth muscle cells, which appear to be mediated by NOS expressed by LPS in vascular smooth muscle. TQA also prevented IL-1 beta-triggered initiation of Arg-induced relaxation and nitrite accumulation.
    CONCLUSIONS:
    These results suggest that TQA prevents LPS-or IL-1 beta-promoted induction of NOS in vascular smooth muscle, thus inhibiting development of Arg-induced vasorelaxation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0451 mL 15.2253 mL 30.4507 mL 60.9013 mL 76.1267 mL
    5 mM 0.609 mL 3.0451 mL 6.0901 mL 12.1803 mL 15.2253 mL
    10 mM 0.3045 mL 1.5225 mL 3.0451 mL 6.0901 mL 7.6127 mL
    50 mM 0.0609 mL 0.3045 mL 0.609 mL 1.218 mL 1.5225 mL
    100 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.609 mL 0.7613 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    雷藤二萜醌B; Triptoquinone B CFN99474 142937-50-6 C20H26O4 = 330.4 5mg QQ客服：1457312923
    Triptoquinone A; Triptoquinone A CFN96475 142950-86-5 C20H24O4 = 328.40 5mg QQ客服：215959384
    雷公藤宁B; Triptinin B CFN96479 189389-05-7 C20H26O3 = 314.42 5mg QQ客服：1413575084
    Triptobenzene H; Triptobenzene H CFN96478 146900-55-2 C21H28O4 = 344.45 5mg QQ客服：215959384
    雷酚萜; Triptonoterpene CFN91646 99694-87-8 C20H28O2 = 300.4 5mg QQ客服：3257982914
    雷公藤乙素; Tripdiolide CFN99197 38647-10-8 C20H24O7 = 376.40 5mg QQ客服：215959384
    雷公藤内酯酮; Triptonide CFN99134 38647-11-9 C20H22O6 = 358.39 20mg QQ客服：2159513211
    雷公藤氯内酯醇; Tripchlorolide CFN91653 132368-08-2 C20H25ClO6 = 396.86 5mg QQ客服：3257982914
    雷酚内酯; Triptophenolide CFN90404 74285-86-2 C20H24O3 = 312.4 20mg QQ客服：2159513211
    雷醌内酯酮; Triptoquinonide CFN99690 163513-81-3 C20H22O4 = 326.4 5mg QQ客服：3257982914

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