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  • 3,4,5-三甲氧基苯甲酸

    Trimethylgallic acid

    3,4,5-三甲氧基苯甲酸
    产品编号 CFN92508
    CAS编号 118-41-2
    分子式 = 分子量 C10H12O5 = 212.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The branches of Eucalyptus globulus Labill.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3,4,5-三甲氧基苯甲酸 CFN92508 118-41-2 10mg QQ客服:1413575084
    3,4,5-三甲氧基苯甲酸 CFN92508 118-41-2 20mg QQ客服:1413575084
    3,4,5-三甲氧基苯甲酸 CFN92508 118-41-2 50mg QQ客服:1413575084
    3,4,5-三甲氧基苯甲酸 CFN92508 118-41-2 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Siksha O Anusandhan University (India)
  • University of Sao Paulo (Brazil)
  • MTT Agrifood Research Finland (Finland)
  • University of Wollongong (Australia)
  • Medizinische Universit?t Wien (Austria)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • FORTH-IMBB (Greece)
  • Charles University in Prague (Czech Republic)
  • Lodz University of Technology (Poland)
  • University of Hull (United Kingdom)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • University of Toronto (Canada)
  • University of Minnesota (USA)
  • Washington State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2020, 25(17):3783.
  • Molecules.2018, 23(3):E615
  • Journal of Life Science2018, 917-922
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • Viruses2023, 15(6), 1377
  • Food and Chemical Toxicology2020, 111221
  • Int J Mol Sci.2018, 19(9):E2681
  • BMC Microbiol.2019, 19(1):78
  • Mutlu Yanic S, Ates EG. JOTCSA.2023, 10(4);893-902.
  • Cell Rep.2022, 39(1):110643.
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Environ Toxicol.2019, 34(4):513-520.
  • Cells.2021, 10(10):2633.
  • The Korea Society of Pha.2014, 300-314
  • Foods.2022, 11(6):882.
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • Eur J Pharmacol.2021, 899:174010.
  • Integr Med Res.2021, 10(3):100723.
  • Food Science and Biotechnology2015, 2205-2212
  • Enzyme Microb Technol.2019, 122:64-73
  • Onco Targets Ther.2017, 10:3467-3474
  • J Nat Prod.2022, doi: 10.1021
  • J Biochem Mol Toxicol.2020, 34(7):e22489.
  • ...
  • 生物活性
    Description: Trimethylgallic acid esters are potent antioxidants and inhibitor of cytokine production, can ameliorate chronic stress-induced various behavioral and biochemical alterations in mice, showing protective effects against chronic stress; they also exert hepatoprotective effects in CCl4-induced rats, specifically by modulating oxidative-nitrosative stress and inflammation.
    Targets: TNF-α
    In vivo:
    Pharmacological Reports Pr, 2014, 66(4): 606-12.
    Effect of trimethylgallic acid esters against chronic stress-induced anxiety-like behavior and oxidative stress in mice.[Pubmed: 24948061 ]

    METHODS AND RESULTS:
    Chronic treatment with Trimethylgallic acid esters for 15 days significantly reversed the chronic stress-induced behavioral (impaired locomotor activity, anxiety-like behavior, and decreased percentage of memory retention), biochemical (increased lipid peroxidation and nitrite levels; decreased glutathione levels, superoxide dismutase and catalase activities), and inflammation surge (serum TNF-α) in stressed mice.
    CONCLUSIONS:
    The study revealed that Trimethylgallic acid esters could ameliorate chronic stress-induced various behavioral and biochemical alterations in mice, showing protective effects against chronic stress.
    Indian J. Exp. Biol., 2015, 53(12):803-9.
    Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats.[Pubmed: 26742325]
    Gallic acid and its derivatives are potential therapeutic agents for treating various oxidative stress mediated disorders.
    METHODS AND RESULTS:
    In the present study, we investigated the hepatoprotective effects of newly synthesized conjugated Trimethylgallic acid (TMGA) esters against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Animals were pre-treated with TMGA esters at their respective doses for 7 days against CCl4-induced hepatotoxicity. The histopathological changes were evaluated to find out degenerative fatty changes including vacuole formation, inflammation and tissue necrosis. Various biomarkers of oxidative stress (lipid peroxidation, glutathione levels, and endogenous antioxidant enzyme activities), liver enzymes (AST and ALT), triacylglycerol and cholesterol were evaluated.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.7125 mL 23.5627 mL 47.1254 mL 94.2507 mL 117.8134 mL
    5 mM 0.9425 mL 4.7125 mL 9.4251 mL 18.8501 mL 23.5627 mL
    10 mM 0.4713 mL 2.3563 mL 4.7125 mL 9.4251 mL 11.7813 mL
    50 mM 0.0943 mL 0.4713 mL 0.9425 mL 1.885 mL 2.3563 mL
    100 mM 0.0471 mL 0.2356 mL 0.4713 mL 0.9425 mL 1.1781 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,4-二甲氧基-5-羟基苯甲酸甲酯; Methyl 3-hydroxy-4,5-dimethoxybenzoate CFN97319 83011-43-2 C10H12O5 = 212.2 20mg QQ客服:2056216494
    3,4,5-三甲氧基苯甲酸; Trimethylgallic acid CFN92508 118-41-2 C10H12O5 = 212.2 20mg QQ客服:1457312923
    3,4,5-三甲氧基苯甲酸甲酯; Trimethylgallic acid methyl ester CFN92412 1916-07-0 C11H14O5 = 226.2 20mg QQ客服:215959384
    2,3-二羟基-4-甲氧基苯甲酸; 2,3-Dihydroxy-4-methoxybenzoic acid CFN94481 3934-81-4 C8H8O5 = 184.1 5mg QQ客服:2056216494
    2-羟基-3,4-二甲氧基苯甲酸; 2-Hydroxy-3,4-dimethoxybenzoic acid CFN94461 5653-46-3 C9H10O5 = 198.17 5mg QQ客服:1413575084
    3,4-二甲氧基-2-羟基苯甲酸甲酯; Methyl 2-hydroxy-3,4-dimethoxybenzoate CFN95383 6395-23-9 C10H12O5 = 212.2 5mg QQ客服:215959384
    没食子酸; 3,4,5-三羟基苯甲酸; Gallic acid CFN99624 149-91-7 C7H6O5 = 170.1 20mg QQ客服:2056216494
    没食子酸甲酯; Methyl gallate CFN93180 99-24-1 C8H8O5 = 184.15 20mg QQ客服:2056216494
    丁香酸; Syringic acid CFN98884 530-57-4 C9H10O5 = 198.2 20mg QQ客服:3257982914
    丁香酸甲酯; Methyl syringate CFN97450 884-35-5 C10H12O5 = 212.2 20mg QQ客服:2159513211

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