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  • 三叶甙

    Trilobatin

    三叶甙
    产品编号 CFN98658
    CAS编号 4192-90-9
    分子式 = 分子量 C21H24O10 = 436.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The herbs of Lithocarpus pachyphyllus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三叶甙 CFN98658 4192-90-9 10mg QQ客服:2056216494
    三叶甙 CFN98658 4192-90-9 20mg QQ客服:2056216494
    三叶甙 CFN98658 4192-90-9 50mg QQ客服:2056216494
    三叶甙 CFN98658 4192-90-9 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Aarhus University (Denmark)
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  • Center for protein Engineering (CIP) (Belgium)
  • Celltrion Chemical Research Institute (Korea)
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  • Istanbul University (Turkey)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2020, 9(11):1121.
  • Nutrients.2018, 10(12):E1998
  • Anal Chim Acta.2021, 1180:338874.
  • Journal of Ginseng Research2019, 10.1016
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Elife.2021, 10:e68058.
  • Neurochem Res.2021, s11064-021-03449-0
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • J Ethnopharmacol.2016, 192:370-381
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • J Ethnopharmacol.2017, 206:73-77
  • J Mol Recognit.2020, 33(2):e2819
  • Int J Mol Sci.2020, 21(22):8816.
  • Front Microbiol.2023, 14:1232039.
  • J Control Release.2021, 336:159-168.
  • Front Pharmacol.2021, 12:607403.
  • J Biomol Struct Dyn.2023, 1-21.
  • Analytical Letters 2021, 54(4).
  • SRM Institute of Sci&Tech2022, 34(1): 32-37
  • Hum Exp Toxicol.2023, 42:9603271221145386.
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Int J Mol Sci.2020, 21(6):2190.
  • J Nat Prod.2019, 82(4):1002-1008
  • ...
  • 生物活性
    Description: Trilobatin has anti-oxidant, and anti-inflammatory effects, it can increase superoxide dismutase (SOD) activity, and it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory response by suppressing the NF-κB signaling pathway. Trilobatin shows a strong inhibitory activity against α-glucosidase and a moderate inhibitory activity against α-amylase for management of postprandial hyperglycemia with less side effect.
    Targets: TNF-α | IL Receptor | IkB | NF-kB | p65 | IKK | SOD
    In vitro:
    Food Chem. 2015 Jan 1;166:609-15.
    Trilobatin attenuates the LPS-mediated inflammatory response by suppressing the NF-κB signaling pathway.[Pubmed: 25053100 ]
    We investigated the anti-inflammatory effect of trilobatin, the flavonoid isolated from the leaves of Lithocarpus polystachyus Rehd, as well as the underlying molecular mechanisms.
    METHODS AND RESULTS:
    Treatment with trilobatin (0.005-5 μM) dose-dependently inhibited the lipopolysaccharide (LPS)-induced mRNA expression and secretion of pro-inflammatory cytokines, including tumor necrosis factor α (TNFα), interleukin-1β (IL-1β) and interleukin-6 (IL-6), in RAW 264.7 macrophages. However, no further inhibition was detected when the concentration of trilobatin was increased to 50 μM. Western blot analysis confirmed that the mechanism of the anti-inflammatory effect was correlated with the inhibition of LPS-induced inhibitor of nuclear factor-kappa B α (IκBα) degradation and nuclear factor-kappa B (NF-κB) p65 phosphorylation. In addition, trilobatin also showed a significant inhibition of LPS-induced TNFα and IL-6 at both the mRNA and protein levels in a mouse model.
    CONCLUSIONS:
    Our results suggest that trilobatin potentially inhibits the LPS-induced inflammatory response by suppressing the NF-κB signaling pathway.
    Z Naturforsch C. 2004 Jul-Aug;59(7-8):481-4.
    Antioxidant activities of three dihydrochalcone glucosides from leaves of Lithocarpus pachyphyllus.[Pubmed: 15813365]
    In vitro antioxidant activities of three sweet dihydrochalcone glucosides from the leaves of Lithocarpus pachyphyllus (Kurz) Rehd. (Fagaceae), trilobatin 2"-acetate (1), phloridzin (2) and trilobatin (3), were investigated.
    METHODS AND RESULTS:
    The IC50 (50% inhibitory concentration) values for compounds 1-3 of lipid peroxidation in rat liver homogenate were 261, 28, 88 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 (50% effective concentration) values of 575, 167, 128 microM, and glutathione peroxidase (GSH-Px) activity with EC50 values of 717, 347, 129 microM, respectively, and showed only weak DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2915 mL 11.4574 mL 22.9148 mL 45.8295 mL 57.2869 mL
    5 mM 0.4583 mL 2.2915 mL 4.583 mL 9.1659 mL 11.4574 mL
    10 mM 0.2291 mL 1.1457 mL 2.2915 mL 4.583 mL 5.7287 mL
    50 mM 0.0458 mL 0.2291 mL 0.4583 mL 0.9166 mL 1.1457 mL
    100 mM 0.0229 mL 0.1146 mL 0.2291 mL 0.4583 mL 0.5729 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Asebotin; Asebotin CFN96929 11075-15-3 C22H26O10 = 450.44 5mg QQ客服:2159513211
    三叶甙; Trilobatin CFN98658 4192-90-9 C21H24O10 = 436.4 20mg QQ客服:2159513211
    三叶甙2''-乙酸酯; Trilobatin 2''-acetate CFN97111 647853-82-5 C23H26O11 = 478.5 5mg QQ客服:1457312923
    Nothofagin; Nothofagin CFN92888 11023-94-2 C21H24O10 = 436.4 5mg QQ客服:1457312923
    根皮素-3',5'-二-C-β-葡萄糖苷; Phloretin 3',5'-Di-C-glucoside CFN95306 357401-40-2 C27H34O15 = 598.2 10mg QQ客服:2159513211
    柚皮苷二氢查尔酮; Naringin dihydrochalcone CFN90437 18916-17-1 C27H34O14 = 582.55 20mg QQ客服:2056216494
    3-羟基根皮苷; Sieboldin CFN70294 18777-73-6 C21H24O11 = 452.4 5mg QQ客服:215959384
    新橙皮苷二氢查尔酮; Neosperidin dihydrochalcone CFN98168 20702-77-6 C28H36O15 = 612.58 20mg QQ客服:215959384
    橙皮苷甲基查尔酮; Hesperidin methylchalcone CFN80405 24292-52-2 C29H36O15 = 624.59 20mg QQ客服:3257982914
    地奥司明杂质5; Diosmin Impurity 5 CFN95311 122087-66-5 C30H38O15 = 638.6 10mg QQ客服:2056216494

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