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  • 苜蓿素

    Tricin

    苜蓿素
    产品编号 CFN98841
    CAS编号 520-32-1
    分子式 = 分子量 C17H14O7 = 330.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Avena sativa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苜蓿素 CFN98841 520-32-1 1mg QQ客服:215959384
    苜蓿素 CFN98841 520-32-1 5mg QQ客服:215959384
    苜蓿素 CFN98841 520-32-1 10mg QQ客服:215959384
    苜蓿素 CFN98841 520-32-1 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Stanford University (USA)
  • University of Wisconsin-Madison (USA)
  • Kyushu University (Japan)
  • University of Sao Paulo (Brazil)
  • Wageningen University (Netherlands)
  • The University of Newcastle (Australia)
  • Seoul National University of Science and Technology (Korea)
  • John Innes Centre (United Kingdom)
  • Georgia Institute of Technology (USA)
  • Universidade do Porto (Portugal)
  • Almansora University (Egypt)
  • Heidelberg University (Germany)
  • Universidad Miguel Hernández (Spain)
  • University of Toulouse (France)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • J Pharm Anal.2016, 6(6):363-373
  • Food Analytical Methods2017, 10:3225–3234
  • Free Radic Biol Med.2017, 112:191-199
  • FEMS Microbiol Lett.2017, 364(11)
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • J Nat Med.2017, 71(2):457-462
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • PLoS One.2018, 13(4):e0195642
  • Neuropharmacology.2018, 131:68-82
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Mol Pharm.2018, 15(8):3285-3296
  • Exp Parasitol.2018, 194:67-78
  • J Sep Sci.2018, 41(11):2488-2497
  • Biochemistry.2018, 57(40):5886-5896
  • Pathogens.2018, 7(3):E62
  • BMC Complement Altern Med.2019, 19(1):325
  • J Funct Foods2019, 54:449-456
  • Ann Transl Med.2019, 7(23):731
  • Biomed Chromatogr.2019, 8:e4774
  • Biosci. Rep.2020, 10.1024
  • ...
  • 生物活性
    Description: Tricin is evaluated as a type of tyrosinase inhibitor, it exerts anti-inflammatory effect via a mechanism involving the TLR4/NF-κB/STAT signaling cascade, tricin derivatives conveys allergy and inflammation treatment ability to Z. latifolia.Tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication, it may be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis.
    Targets: TLR | p38MAPK | JNK | NF-kB | Phospholipase (e.g. PLA) | Tyrosinase | COX | JAK | STAT | HSC
    In vitro:
    Biosci Biotechnol Biochem. 2015 May;79(5):700-6.
    Tricin derivatives as anti-inflammatory and anti-allergic constituents from the aerial part of Zizania latifolia.[Pubmed: 25559019]

    METHODS AND RESULTS:
    Methanol extract of Zizania latifolia was partitioned with EtOAc, n-BuOH, and H2O. From the EtOAc layers, a new flavonolignan along with a known flavone and three known flavonolignans, Tricin (1), salcolin A (2), salcolin B (3), and salcolin C (4), were isolated through repeated silica gel and ODS column chromatography. The chemical structure of the new flavonolignan was determined to be Tricin-4'-O-[erythro-β-guaiacyl-(7″-O-methyl)-glyceryl] ether and was named salcolin D (5) based on physicochemical and spectroscopic data, including FT-NMR and ESI-MS. All compounds were isolated for the first time from this plant. Compounds 2-5, Tricin derivatives, all exhibited higher anti-inflammatory and anti-allergy activities than Tricin. In particular, salcolin D (5) was shown to have the strongest inhibitory activity against LPS-induced NO production in RAW 264.7 cells as well as β-hexosaminidase release in IgE-sensitized RBL-2H3 cells.
    CONCLUSIONS:
    These results suggest that the presence of Tricin derivatives conveys allergy and inflammation treatment ability to Z. latifolia.
    Microbes Infect. 2012 Oct;14(12):1086-92.
    Anti-cytomegalovirus effects of tricin are dependent on CXCL11.[Pubmed: 22683667]
    It has been reported that treatment with Tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection significantly suppressed both infectious virus production and HCMV replication in the human embryonic fibroblast cell line MRC-5.
    METHODS AND RESULTS:
    In this paper, we examined the mechanisms for the anti-HCMV effects of Tricin in MRC-5 cells. Exposure of fibroblasts to Tricin inhibited infectious HCMV production, with concomitant decreases in levels of transcripts of the CXC chemokine IFN-inducible T cell alpha chemoattractant (I-TAC or CXCL11) gene. We also found that the transcripts of the HCMV immediate early (IE) gene and replication of HCMV were lower in CXCL11 gene-knockdown cells.
    CONCLUSIONS:
    These results suggest that Tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. In addition, it is possible that CXCL11 is the one of the targets of Tricin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0276 mL 15.1378 mL 30.2755 mL 60.551 mL 75.6888 mL
    5 mM 0.6055 mL 3.0276 mL 6.0551 mL 12.1102 mL 15.1378 mL
    10 mM 0.3028 mL 1.5138 mL 3.0276 mL 6.0551 mL 7.5689 mL
    50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.211 mL 1.5138 mL
    100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黄芩黄酮II; Skullcapflavone II CFN92216 55084-08-7 C19H18O8 = 374.4 10mg QQ客服:1413575084
    3',5,5',7-四羟基-4',6-二甲氧基黄酮; 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone CFN99369 125537-92-0 C17H14O8 = 346.3 5mg QQ客服:2159513211
    5,7,3'-三羟基-6,4',5'-三甲氧基黄酮; 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone CFN90939 78417-26-2 C18H16O8 = 360.3 5mg QQ客服:1413575084
    三粒小麦黄酮; Tricetin CFN70392 520-31-0 C15H10O7 = 302.2 5mg QQ客服:215959384
    苜蓿素; Tricin CFN98841 520-32-1 C17H14O7 = 330.3 5mg QQ客服:2932563308
    4',5-二羟基-3',5',6,7-四甲氧基黄酮; 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone CFN97322 83133-17-9 C19H18O8 = 374.4 5mg QQ客服:3257982914
    5,3'-二羟基-6,7,4',5'-四甲氧基黄酮; 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone CFN99214 111537-41-8 C19H18O8 = 374.4 5mg QQ客服:1148253675
    5,7-二羟基-3',4',5'-三甲氧基黄酮; 5,7-Dihydroxy-3',4',5'-trimethoxyflavone CFN96493 18103-42-9 C18H16O7 = 344.32 5mg QQ客服:3257982914
    伞房花耳草素; Corymbosin CFN96498 18103-41-8 C19H18O7 = 358.34 5mg QQ客服:2932563308
    奇蒿黄酮; Arteanoflavone CFN96510 68710-17-8 C19H18O8 = 374.35 5mg QQ客服:215959384

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