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  • 飞龙掌血内酯

    Toddaculine

    飞龙掌血内酯
    产品编号 CFN92733
    CAS编号 4335-12-0
    分子式 = 分子量 C16H18O4 = 274.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Toddalia asiatica Lam.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    飞龙掌血内酯 CFN92733 4335-12-0 1mg QQ客服:2056216494
    飞龙掌血内酯 CFN92733 4335-12-0 5mg QQ客服:2056216494
    飞龙掌血内酯 CFN92733 4335-12-0 10mg QQ客服:2056216494
    飞龙掌血内酯 CFN92733 4335-12-0 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Copenhagen University (Denmark)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Universidade de Franca (Brazil)
  • Universidad Industrial de Santander (Colombia)
  • Yale University (USA)
  • University of Vigo (Spain)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Biotech R&D Institute (USA)
  • Washington State University (USA)
  • University of Melbourne (Australia)
  • Universit?t Basel (Switzerland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2020, 21(19):7209.
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • University of Central Lancashire2017, 20472
  • Legume Science2021, 3(4): e101.
  • J Food Biochem.2019, 43(9):e12970
  • China Pharmacy2015, 26(27)
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Front Pharmacol.2017, 8:673
  • Sci Rep.2018, 8:15059
  • Korean J. Food Sci. & Technol.2022, 54(2):241-246
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Molecules.2019, 24(24),4583
  • Life Sci.2019, 216:259-270
  • Reprod Toxicol.2020, 96:1-10.
  • Foods.2023, 12(12):2412.
  • Molecules2022, 27(9):2992.
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Sci Rep. 2017, 17332(7)
  • Phytomedicine.2018, 47:48-57
  • Antiviral Res.2013, 98(3):386-93
  • J of L. Chroma.&Related Tech2017, 252-258
  • Planta Med.2022, a-1876-3009.
  • Carbohydrate Polymer Technologies & App.2021, 2:100049.
  • ...
  • 生物活性
    Description: Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can induce differentiation and mineralization of osteoblasts by regulating differentiation factors. Toddaculine also may serve as a pharmacological prototype for the development of novel anti-leukemic agents, it displays a dual effect as a cell differentiating agent and apoptosis inducer in U-937 cells.
    Targets: NF-kB | p38MAPK | ERK | Akt
    In vitro:
    PLoS One. 2015 May 18;10(5):e0127158.
    Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells.[Pubmed: 25993011 ]
    Osteoporosis with bone loss is widely recognized as a major health problem. Bone homeostasis is maintained by balancing bone formation and bone resorption. The imbalance caused by increased bone resorption over bone formation can lead to various bone-related diseases such as osteoporosis and rheumatoid arthritis. Osteoclasts are the principal cells responsible for bone resorption and the main targets of anti-resorptive therapies. However, excessive inhibition of osteoclast differentiation may lead to inhibition of osteoblast differentiation. Therefore, it is important to screen for new compounds capable of inhibiting bone resorption and enhancing bone formation. Toddalia asiatica (L.) Lam. has been utilized traditionally for medicinal purposes such as the treatment of rheumatism. Currently, the extract is considered to be a good source of pharmacological agents for the treatment of bone-related diseases, but the active compounds have yet to be identified.
    METHODS AND RESULTS:
    We investigated whether toddaculin(Toddaculine) , derived from Toddalia asiatica (L.) Lam., affects both processes by inhibiting bone resorption and enhancing bone formation. Towards this end, we used pre-osteoclastic RAW 264 cells and pre-osteoblastic MC3T3-E1 cells. We found that toddaculin(Toddaculine) not only inhibited the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but it also induced differentiation and mineralization of osteoblasts by regulating differentiation factors.
    CONCLUSIONS:
    Thus, toddaculin(Toddaculine) might be beneficial for the prevention and treatment of osteoporosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6456 mL 18.2282 mL 36.4564 mL 72.9129 mL 91.1411 mL
    5 mM 0.7291 mL 3.6456 mL 7.2913 mL 14.5826 mL 18.2282 mL
    10 mM 0.3646 mL 1.8228 mL 3.6456 mL 7.2913 mL 9.1141 mL
    50 mM 0.0729 mL 0.3646 mL 0.7291 mL 1.4583 mL 1.8228 mL
    100 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.7291 mL 0.9114 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    白花前胡醇; Peucedanol CFN99738 28095-18-3 C15H18O5 = 278.30 5mg QQ客服:2056216494
    (R)-白花前胡醇 3'-O-beta-D-吡喃葡萄糖苷; Peucedanol 3'-O-glucoside CFN89411 65891-61-4 C20H26O10 = 426.41 5mg QQ客服:1413575084
    (R)-白花前胡醇 7-O-beta-D-吡喃葡萄糖苷; Peucedanol 7-O-glucoside CFN89412 65853-04-5 C20H26O10 = 426.41 5mg QQ客服:2159513211
    Peujaponiside; Peujaponiside CFN93412 155740-16-2 C25H34O14 = 558.5 5mg QQ客服:2056216494
    当归醇A; Angelol A CFN90999 19625-17-3 C20H24O7 = 376.4 10mg QQ客服:1413575084
    当归醇M; Angelol M CFN95060 1092952-64-1 C20H24O7 = 376.4 5mg QQ客服:1457312923
    当归醇B; Angelol B CFN91000 83156-04-1 C20H24O7 = 376.4 10mg QQ客服:1413575084
    当归醇K; Angelol K CFN80136 169736-93-0 C20H24O7 = 376.15 5mg QQ客服:1413575084
    当归醇G; Angelol G CFN92988 83199-38-6 C20H24O7 = 376.40 10mg QQ客服:2056216494
    当归醇H; Angelol H CFN91925 83247-73-8 C20H24O7 = 376.40 5 mg QQ客服:1457312923

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