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  • Tilifodiolide

    • Tilifodiolide

    Tilifodiolide

    Tilifodiolide
    		产品编号 CFN99378
    CAS编号 126724-95-6
    分子式 = 分子量 C20H16O5 = 336.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Salvia tiliaefolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Tilifodiolide CFN99378 126724-95-6 1mg QQ客服：2159513211
    Tilifodiolide CFN99378 126724-95-6 5mg QQ客服：2159513211
    Tilifodiolide CFN99378 126724-95-6 10mg QQ客服：2159513211
    Tilifodiolide CFN99378 126724-95-6 20mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Utah State University (USA)
  • Aveiro University (Portugal)
  • University of Indonesia (Indonesia)
  • Amity University (India)
  • Charles University in Prague (Czech Republic)
  • Kazusa DNA Research Institute (Japan)
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  • Almansora University (Egypt)
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  • Universita' Degli Studi Di Cagliari (Italy)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • RSC Advances2017, 86
  • J AOAC Int.2023, 106(1):56-64.
  • Phytother Res.2019, 33(4):1104-1113
  • Planta Med.2018, 84(6-07):465-474
  • Int J Mol Sci.2021, 22(14):7324.
  • Int J Biol Macromol.2020, 169:342-351
  • Eur J Pharmacol.2021, 899:174010.
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • Med Sci Monit.2019, 25:9499-9508
  • J Ethnopharmacol.2017, 209:305-316
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Oxid Med Cell Longev2020, 12
  • Int J Nanomedicine.2022, 17:6513-6525.
  • Pharmacognosy Journal, 2021, 13(5).
  • Biomolecules2021, 11(10),1513.
  • J of Food Quality2020, 8851285.
  • Pest Manag Sci.2023, 79(8):2675-2685.
  • Sci Rep.2019, 9:12132
  • Processes2021, 9(5),831.
  • Plant Biotechnology Reports 2021, 15:117-124.
  • Molecules.2020, 25(15):3353.
  • Molecules.2021, 26(9):2765.
  • Molecules2022, 27(12):3824.
  • ...
    • 生物活性
    Description: Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effects mediated by nitric oxide and cyclic guanosine monophosphate, it also showed anxiolytic and antidepressant effects by the partial involvement of gamma-Aminobutyric acid (GABA) receptors and the possible participation of α2-adrenoreceptors, respectively.
    Targets: TNF-α | IL-6 | GABA Receptor
    In vivo:
    Drug Development Research, 2018, 79(4):165.
    Anti-inflammatory and antinociceptive effects of tilifodiolide, isolated from Salvia tiliifolia Vahl (Lamiaceae).[Reference: WebLink]
    Salvia tiliifolia Vahl (Lamiaceae) is used for the empirical treatment of pain and inflammation. The diterpenoid tilifodiolide (TFD) was isolated from Salvia tiliifolia.
    METHODS AND RESULTS:
    The in vitro anti-inflammatory effects of TFD (0.1-200 µM) were assessed using murine macrophages stimulated with LPS and estimating the levels of pro-inflammatory mediators for 48 h. The in vivo anti-inflammatory activity of TFD was assessed using the carrageenan-induced paw edema test for 6 h. The antinociceptive effects of TFD were evaluated using the formalin test and the acetic acid induced-writhing test. The effects of TFD on locomotor activity were assessed using the open field test and the rotarod test. TFD inhibited the production of TNF-α (IC50  = 5.66 µM) and IL-6 (IC50  = 1.21 µM) in macrophages. TFD (200 mg/kg) showed anti-inflammatory effects with similar activity compared to 10 mg/kg indomethacin. The administration of TFD induced antinociception in the phase 1 (ED50  = 48.2 mg/kg) and the phase 2 (ED50  = 28.9 mg/kg) of the formalin test. In the acetic acid assay, TFD showed antinociceptive effects (ED50  = 32.3 mg/kg) with similar potency compared to naproxen (ED50  = 36.2 mg/kg).
    CONCLUSIONS:
    In the presence of different inhibitors in the acetic acid assay, only the co-administration of TFD and naloxone reverted the antinociceptive activity shown by TFD alone. TFD did not affect locomotor activity in mice. TFD exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9735 mL 14.8677 mL 29.7354 mL 59.4707 mL 74.3384 mL
    5 mM 0.5947 mL 2.9735 mL 5.9471 mL 11.8941 mL 14.8677 mL
    10 mM 0.2974 mL 1.4868 mL 2.9735 mL 5.9471 mL 7.4338 mL
    50 mM 0.0595 mL 0.2974 mL 0.5947 mL 1.1894 mL 1.4868 mL
    100 mM 0.0297 mL 0.1487 mL 0.2974 mL 0.5947 mL 0.7434 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Isosalvipuberulin; Isosalvipuberulin CFN99251 115321-32-9 C20H14O5 = 334.3 5mg QQ客服：3257982914
    Tilifodiolide; Tilifodiolide CFN99378 126724-95-6 C20H16O5 = 336.3 5mg QQ客服：1413575084
    Dodonolide; Dodonolide CFN97753 349534-73-2 C20H24O3 = 312.41 5mg QQ客服：1413575084
    黄独素D; Diosbulbin D CFN97140 66756-57-8 C19H20O6 = 344.4 5mg QQ客服：1457312923
    8-表黄药子素E乙酸酯; 8-Epidiosbulbin E acetate CFN90907 91095-48-6 C21H24O7 = 388.40 20mg QQ客服：2159513211
    黄独素I; Diosbulbin I CFN99288 1187951-05-8 C29H30O8 = 506.6 5mg QQ客服：215959384
    黄独素 L; Diosbulbin L CFN89003 1236285-87-2 C19H22O7 = 362.37 5mg QQ客服：1457312923
    黄独素J; Diosbulbin J CFN99289 1187951-06-9 C19H22O8 = 378.4 5mg QQ客服：1457312923
    Borapetoside A; Borapetoside A CFN95658 100202-29-7 C26H34O12 = 538.6 10mg QQ客服：1457312923
    Borapetoside B; Borapetoside B CFN96298 104901-05-5 C27H36O12 = 552.6 5mg QQ客服：3257982914

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