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  • 巴豆酰戈米辛 H

    Tigloylgomisin H

    巴豆酰戈米辛 H
    产品编号 CFN96618
    CAS编号 66069-55-4
    分子式 = 分子量 C28H36O8 = 500.59
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Schisandra chinensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    巴豆酰戈米辛 H CFN96618 66069-55-4 1mg QQ客服:1457312923
    巴豆酰戈米辛 H CFN96618 66069-55-4 5mg QQ客服:1457312923
    巴豆酰戈米辛 H CFN96618 66069-55-4 10mg QQ客服:1457312923
    巴豆酰戈米辛 H CFN96618 66069-55-4 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Aging Neurosci.2018, 10:269
  • J Nat Prod.2017, 80(4):854-863
  • Food and Fermentation Industries2019, 45(7):45-51
  • Applied Biological Chem. 2020, 26(63).
  • Acta horticulturae2017, 1158:257-268
  • Int J Mol Sci.2020, 21(19),7070.
  • Plants (Basel).2023, 12(22):3877.
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  • Enzyme Microb Technol.2022, 161:110111.
  • Cancer Manag Res.2019, 11:483-500
  • Plant Cell Tiss Org2017, 479-486
  • South African Journal of Botany2021, 142:114-123.
  • Microb Biotechnol.2021, 14(5):2009-2024.
  • J Pharm Anal.2016, 6(6):363-373
  • Antioxidants (Basel).2022, 11(12):2327.
  • Journal of Apiculture2019, 34(2):131-136
  • Front Pharmacol.2022, 13:906763.
  • Int J Mol Sci.2022, 23(11):6172.
  • Sci Rep.2020, 10:4495(2020)
  • Oncotarget.2016, 8(51):88386-88400
  • Planta Med.2023, 2192-2281
  • Int Immunopharmacol.2023, 7:127:111322.
  • J Food Sci Technol.2022, 59(1):212-219.
  • ...
  • 生物活性
    Description: Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells, it functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway.
    Targets: Nrf2 | ARE
    In vitro:
    Planta Med. 2009 Oct;75(12):1314-8.
    Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2.[Pubmed: 19452436]
    The upregulation of phase II detoxification genes is believed to play an important role in cancer prevention. The molecular mechanism underlying the changes in gene expression that accompany cancer prevention involves activation of the transcription factor, NF-E2-related factor 2 (Nrf2). In traditional medicine, the fruit of Schisandra chinensis Baill is used as a tonic, an anti-tussive and an anti-aging drug.
    METHODS AND RESULTS:
    In the current study, nine lignans were isolated from S. chinensis and tested for their ability to induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H (TGH) and angeloylgomisin H (AGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) (10.80 and 4.59, respectively) as compared to control. TGH also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, TGH significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2.
    CONCLUSIONS:
    The results of the current study suggest that TGH functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway. TGH thus represents a potential liver cancer prevention agent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9976 mL 9.9882 mL 19.9764 mL 39.9529 mL 49.9411 mL
    5 mM 0.3995 mL 1.9976 mL 3.9953 mL 7.9906 mL 9.9882 mL
    10 mM 0.1998 mL 0.9988 mL 1.9976 mL 3.9953 mL 4.9941 mL
    50 mM 0.04 mL 0.1998 mL 0.3995 mL 0.7991 mL 0.9988 mL
    100 mM 0.02 mL 0.0999 mL 0.1998 mL 0.3995 mL 0.4994 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    南五味子素; Kadsurin CFN92728 51670-40-7 C25H30O8 = 458.5 5mg QQ客服:1457312923
    表戈米辛O; Epigomisin O CFN90733 73036-31-4 C23H28O7 = 416.46 5mg QQ客服:1457312923
    戈米辛O; Gomisin O CFN90751 72960-22-6 C23H28O7 = 416.46 10mg QQ客服:1413575084
    当归酰基戈米辛 O; Angeloylgomisin O CFN89067 83864-69-1 C28H34O8 = 498.57 10mg QQ客服:1413575084
    鹤庆五味子癸素; Schisanwilsonin I CFN98732 1181216-84-1 C28H34O9 = 514.6 5mg QQ客服:3257982914
    内南五味子酯 C; Interiotherin C CFN92730 460090-65-7 C30H36O10 = 556.6 5mg QQ客服:1457312923
    滇藏五味子素G; Negsehisandrin G CFN90533 1023744-69-5 C28H36O7 = 484.6 10mg QQ客服:2159513211
    五味子酯乙; Schisantherin B CFN99924 58546-55-7 C28H34O9 = 514.57 20mg QQ客服:3257982914
    五味子酯甲; Schisantherin A CFN99925 58546-56-8 C30H32O9 = 536.56 20mg QQ客服:2159513211
    戈米辛D; Gomisin D CFN90122 60546-10-3 C28H34O10 = 530.56 20mg QQ客服:1413575084

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