(+)-花旗松素

(+)-Taxifolin

	产品编号	CFN99183
	CAS编号	17654-26-1
	分子式 = 分子量	C₁₅H₁₂O₇ = 304.25
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The herbs of Silybum marianum (L.) Gaertn.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
(+)-花旗松素	CFN99183	17654-26-1	10mg	QQ客服：2056216494
(+)-花旗松素	CFN99183	17654-26-1	20mg	QQ客服：2056216494
(+)-花旗松素	CFN99183	17654-26-1	50mg	QQ客服：2056216494
(+)-花旗松素	CFN99183	17654-26-1	100mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sanford Burnham Prebys Medical Discovery Institute (USA)

University of Auckland (New Zealand)

Tohoku University (Japan)

University of Wollongong (Australia)

Auburn University (USA)

Monash University Malaysia (Malaysia)

Universidade Católica Portuguesa (Portugal)

Universidade Federal de Goias (UFG) (Brazil)

University of Leipzig (Germany)

Technical University of Denmark (Denmark)

University of Wisconsin-Madison (USA)

Max-Planck-Insitut (Germany)

Amity University (India)

Seoul National University of Science and Technology (Korea)

More...

Description:

(+)-Taxifolin is an inhibitor of aggregation of the 42-residue amyloid β-protein, it has preventive effects against Alzheimer's disease-like pathogenesis in vivo. It is also a weak inhibitor of cytochrome b5 reduction (IC50=9.8μM).

Targets:

Beta Amyloid

In vitro:

Toxicology. 2013 Jun 7;308:34-40.

In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase.[Pubmed: 23567315 ]

The microsomal NADH-dependent electron transport system consisting of cytochrome b5 reductase and cytochrome b5 participates in a number of physiologically important processes including lipid metabolism as well as is involved in the metabolism of various drug and xenobiotics.
METHODS AND RESULTS:
In the present study, we assessed the inhibitory effects of eight dietary flavonoids representing five distinct chemical classes on cytochrome b5 reduction by purified cytochrome b5 reductase. From the flavonoids tested, myricetin was the most potent in inhibiting cytochrome b5 reduction with an IC50 value of 0.35μM. Myricetin inhibited b5 reductase noncompetitively with a Ki of 0.21μM with respect to cofactor NADH, and exhibited a non-linear relationship indicating non-Michaelis-Menten kinetic binding with respect to cytochrome b5. In contrast to the potent inhibitory activity of myricetin, (+)-Taxifolin was found to be a weak inhibitor (IC50=9.8μM). The remaining flavonoids were inactive within the concentration range tested (1-50μM). Analysis of structure-activity data suggested that simultaneous presence of three OH groups in ring B is a primary structural determinant for a potent enzyme inhibition.
CONCLUSIONS:
Our results suggest that inhibition of the activity of this system by myricetin or myricetin containing diets may influence the metabolism of therapeutic drugs as well as detoxification of xenobiotics.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
茯苓酸AM; Poricoic acid AM	CFN91538	151200-92-9	C₃₂H₄₈O₅ = 512.7	5mg	QQ客服：3257982914
氯化飞燕草素-3,5-O-二葡萄糖苷; Delphinidin-3,5-O-diglucoside chloride	CFN92137	17670-06-3	C₂₇H₃₁O₁₇Cl = 663.0	5mg	QQ客服：2159513211
大豆皂苷Ac; Soyasaponin Ac	CFN90774	133882-74-3	C₆₇H₁₀₄O₃₂ = 1421.6	5mg	QQ客服：215959384
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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2868 mL	16.4339 mL	32.8677 mL	65.7354 mL	82.1693 mL
5 mM	0.6574 mL	3.2868 mL	6.5735 mL	13.1471 mL	16.4339 mL
10 mM	0.3287 mL	1.6434 mL	3.2868 mL	6.5735 mL	8.2169 mL
50 mM	0.0657 mL	0.3287 mL	0.6574 mL	1.3147 mL	1.6434 mL
100 mM	0.0329 mL	0.1643 mL	0.3287 mL	0.6574 mL	0.8217 mL