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  • 丹参酮IIA-磺酸钠

    Tanshinone IIA-sulfonic sodium

    丹参酮IIA-磺酸钠
    产品编号 CFN90399
    CAS编号 69659-80-9
    分子式 = 分子量 C19H17O6S.Na = 396.39
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹参酮IIA-磺酸钠 CFN90399 69659-80-9 10mg QQ客服:3257982914
    丹参酮IIA-磺酸钠 CFN90399 69659-80-9 20mg QQ客服:3257982914
    丹参酮IIA-磺酸钠 CFN90399 69659-80-9 50mg QQ客服:3257982914
    丹参酮IIA-磺酸钠 CFN90399 69659-80-9 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universita' Degli Studi Di Cagliari (Italy)
  • Wroclaw Medical University (Poland)
  • National Cancer Institute (USA)
  • Osmania University (India)
  • University of Vigo (Spain)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Universidade Federal de Santa Catarina (Brazil)
  • Washington State University (USA)
  • University of Canterbury (New Zealand)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Vienna (Austria)
  • Medical University of South Carolina (USA)
  • Almansora University (Egypt)
  • Wageningen University (Netherlands)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Phytopathology2021, 169,Issue11-12.
  • American Association for Anatomy2020, doi: 10.1002.
  • Chem Biodivers.2023, 20(10):e202300741.
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • J Ethnopharmacol.2020, 249:112381
  • Phytomedicine2022, 104:154337.
  • Int J Mol Med.2019, 43(6):2516-2522
  • Int J Mol Sci.2022, 23(5):2796.
  • Data Science for Genomics2023, 107-128.
  • Am J Chin Med.2016, 44(6):1255-1271
  • Int J Mol Sci.2020, 21(7):2530.
  • The Korea Journal of Herbology2016, 29-35
  • Int J Mol Sci.2022, 23(21):12816.
  • J Ginseng Res.2020, 44(4):611-618.
  • Horticulture Research2022, uhac276.
  • Phytother Res.2016, 30(12):2020-2026
  • Horticulturae2021, 7(1),5.
  • Phytomedicine.2019, 62:152962
  • Cell Prolif.2021, 54(8):e13083.
  • BMC Complement Altern Med.2019, 19(1):367
  • Molecules.2019, 24(10):E1930
  • Nutrients.2019, 11(4):E936
  • J Biomed Sci.2020, 27(1):60.
  • ...
  • 生物活性
    Description: Tanshinone IIA sulfonate (sodium) is a water-soluble derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.Sodium tanshinone IIA sulfonate pretreatment reduces infarct size and improves cardiac function in an ischemia-reperfusion-induced rat myocardial injury model via activation of Akt/FOXO3A/Bim-mediated signal pathway.
    Targets: Akt | FOXO3A | Bim | Calcium Channel
    In vitro:
    Food Chem Toxicol. 2009 Jul;47(7):1538-44.
    Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.[Pubmed: 19358873 ]
    Although doxorubicin (DXR) is an effective antineoplastic agent; the serious cardiotoxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. Our hypothesis is that Tanshinone IIA-sulfonic sodium (TSNIIA-SS), which holds significant affects on cardioprotection in clinic, protects against DXR-induced cardiotoxicity.
    METHODS AND RESULTS:
    In vitro investigation on H9c2 cell line, as well as in vivo study in animal model of DXR-induced chronic cardiomyopathy were performed. TSNIIA-SS significantly increased cell viability and ameliorated apoptosis of DXR-injured H9c2 cells using CCK-8 assay and Hoechst 33342 stain respectively. Furthermore, the cardio-protective effects of TSNIIA-SS were confirmed with decreasing ST-interval and QRS interval by electrocardiography (ECG); improving appearance of myocardium with haematoxylin and eosin (H&E) stain; increasing myocardial tensile strength using tension to rupture (TTR) assay and decreasing fibrosis through picric-sirius red staining comparing with those receiving DXR alone.
    CONCLUSIONS:
    These data have provided the considerable evidences that TSNIIA-SS is a protective agent against DXR-induced cardiac injury.
    In vivo:
    《Strait Pharmaceutical Journal》 2010-05
    Influence of tanshinone on glutamic acid content in spinal cord and serum in a rat model of spinal cord ischemia/reperfusion injury[Reference: WebLink]
    To explore the interventional effect of tanshinone on glutamic acid content in spinal cord and in serum and neurological function in a rat model of spinal cord ischemia/reperfusion injury.
    METHODS AND RESULTS:
    A total of 88 Sprague Dawley rats were randomly divided into a sham operation(n=8),model(n=40),and tanshinone(n=40) groups.Abdominal aorta occlusion was performed along the right renal arterial root using a Scoville-Lewis clamp to induce spinal cord ischemia.Blood flow was recovered 30 minutes following occlusion to establish models of spinal cord ischemia/reperfusion injury.Abdominal aorta occlusion was not performed in the sham operation group.An intraperitoneal injection of Tanshinone IIA-sulfonic sodium solution was administered to rats in the tanshinone group,preoperatively.In addition,rats in the sham operation and model groups were treated with an intraperitoneal injection of the same concentration of saline,preoperatively.Tirty minutes after ischemia,rats in the model and tanshinone groups were observed at 30min,hour1,4,8,and 12 following perfusion,with eight rats for each time point.After cutting the spinal cord and drawing the blood from inferior vena cava at each time point we detected glutamic acid content in spinal cord and glutamic acid content in serum.At hour 4,8,and 12 following perfusion,evaluated neurological fuction using Tarlov method in model and tanshinone groups. All 88 rats were included in the final analysis.Glutamic acid content in spinal and serum of model and tanshinone groups rose ischemia/reperfusion injury 30min later,reached a peak 4 hours after reperfusion,fall-off thenceforth,and put back 12 hours after reperfusion.
    CONCLUSIONS:
    Tanshinone could reduce glutamic acid content in spinal cord and protected neurological function in a rat model of spinal cord ischemia/reperfusion injury.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5228 mL 12.6138 mL 25.2277 mL 50.4554 mL 63.0692 mL
    5 mM 0.5046 mL 2.5228 mL 5.0455 mL 10.0911 mL 12.6138 mL
    10 mM 0.2523 mL 1.2614 mL 2.5228 mL 5.0455 mL 6.3069 mL
    50 mM 0.0505 mL 0.2523 mL 0.5046 mL 1.0091 mL 1.2614 mL
    100 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.5046 mL 0.6307 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新化合物20; New compound 20 CFN95545 N/A C30H42O7 = 514.7 5mg QQ客服:215959384
    6,9,10-三羟基-7-巨豆烯-3-酮; 6,9,10-Trihydroxy-7-megastigmen-3-one CFN98717 476682-97-0 C13H22O4 = 242.3 5mg QQ客服:215959384
    5,8-Epidioxyergosta-6,9(11),22-trien-3-ol; 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol CFN93118 86363-50-0 C28H42O3 = 426.63 5mg QQ客服:2056216494
    花椒素; Xanthoxylin CFN97465 90-24-4 C10H12O4 = 196.2 20mg QQ客服:1413575084

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