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  • 丹参酮IIA

    Tanshinone IIA

    丹参酮IIA
    产品编号 CFN98952
    CAS编号 568-72-9
    分子式 = 分子量 C19H18O3 = 294.4
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    丹参酮IIA CFN98952 568-72-9 10mg QQ客服:1413575084
    丹参酮IIA CFN98952 568-72-9 20mg QQ客服:1413575084
    丹参酮IIA CFN98952 568-72-9 50mg QQ客服:1413575084
    丹参酮IIA CFN98952 568-72-9 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Worcester Polytechnic Institute (USA)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • National Chung Hsing University (Taiwan)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Hamdard University (India)
  • Florida A&M University (USA)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University Medical Center Mainz (Germany)
  • Ateneo de Manila University (Philippines)
  • Universidad Miguel Hernández (Spain)
  • Julius Kühn-Institut (Germany)
  • Yale University (USA)
  • University of Maryland School of Medicine (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Inflammation2015, 38(1):445-55
  • Food Research International2016, 106-113
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Integr Med Res.2017, 6(4):395-403
  • Front Immunol.2017, 8:1542
  • Front Pharmacol.2017, 8:205
  • ACS Nano.2018, 12(4):3385-3396
  • PLoS One.2018, 13(4):e0195642
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Mol Pharm.2018, 15(8):3285-3296
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Academic J of Second Military Medical University2018, 39(11)
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Mol Cells.2018, 41(8):771-780
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • Front Pharmacol.2018, 9:756
  • Nutrients.2019, 11(4):E936
  • Comput Biol Chem.2019, 83:107096
  • Sci Rep.2019, 9:12132
  • J Sep Sci.2020, 201901140
  • J Ethnopharmacol.2020, 249:112396
  • ...
  • 生物活性
    Description: Tanshinone IIA is an estrogen receptor partial agonist with antiandrogenic properties, it has neuroprotective effects against cerebral ischemia/reperfusion injury and traumatic injury of the spinal cord in rats. Tanshinone IIA has anti-leukemia, anti-inflammatory and anti-oxidative properties, inhibits the release of inflammatory cytokines, such as, IL-1 β, IL-6 α, TNF-α.
    Targets: Estrogen receptor | NADPH-oxidase | NOS | ROS | JNK | ERK | Bcl-2/Bax | Caspase | p53 | p38MAPK | IL Receptor | TNF-α | PARP | Progestogen receptor
    In vitro:
    Ann Plast Surg. 2015 Jun 20.
    Tanshinone IIA Inhibits Proliferation and Induces Apoptosis Through the Downregulation of Survivin in Keloid Fibroblasts.[Pubmed: 26101974]
    Keloids are considered benign dermal fibroproliferative tumors. Keloid fibroblasts (KFs) persistently proliferate and fail to undergo apoptosis, and no treatment is completely effective against these lesions. Tanshinone IIA induces apoptosis and inhibits the proliferation of various tumor cell types. In this study, we investigated the effect of tanshinone IIA on the regulation of proliferation, cell cycle, and apoptosis in KFs, and investigated potential mechanisms involved in the effects.
    METHODS AND RESULTS:
    First, KFs and normal skin fibroblasts (NSFs) were treated with various concentrations of tanshinone IIA. Cell counting kit-8 (CCK-8) was used to assess the proliferative activity of KFs and NSFs, and flow cytometry was used to investigate the cell cycle and apoptosis in KFs. We found that the proliferation of all tanshinone IIA-treated KFs was significantly decreased after treatment for 72 hours (P < 0.001). Also, NSFs treated with tanshinone IIA did not exhibit noticeable effects compared with KFs. In addition, the percentages of G0/G1 cells in all tanshinone IIA-treated KFs were significantly increased after treatment for 72 hours (P < 0.001). And the percentages of cells undergoing early apoptosis in all tanshinone IIA-treated KFs were significantly increased after treatment for 120 hours (P < 0.001). Furthermore, the apoptosis antibody array kit and Western blot analysis revealed that tanshinone IIA decreased survivin expression in KFs (P < 0.001).
    CONCLUSIONS:
    In conclusion, tanshinone IIA downregulates survivin and deactivates KFs, thus suggesting that tanshinone IIA could serve as a potential clinical keloid treatment.
    Planta Med. 2015 May;81(7):578-85.
    Anabolic Effect of the Traditional Chinese Medicine Compound Tanshinone IIA on Myotube Hypertrophy Is Mediated by Estrogen Receptor.[Pubmed: 26018796]
    Skeletal muscle loss during menopause is associated with a higher risk of developing diabetes type II and the general development of the metabolic syndrome. Therefore, strategies combining nutritional and training interventions to prevent muscle loss are necessary. Danshen Si Wu is a traditional Chinese medicine used for menopausal complains. One of the main compounds of Danshen Si Wu is tanshinone IIA. Physiological effects of tanshinone IIA have been described as being mediated via the estrogen receptor. Therefore, it was the aim of this study to determine its tissue specific ERα- and ERβ-mediated estrogenic activity, to investigate its antiestrogenic properties, and, particularly, to study estrogen receptor-mediated biological responses to tanshinone IIA on skeletal muscle cells.
    METHODS AND RESULTS:
    The purity of tanshinone IIA was analyzed by LC-DAD-MS/MS analysis. ERα/ERβ-mediated activity was dose-dependently analyzed in HEK 239 cells transfected with ERα or ERβ expression vectors and respective reporter genes. Androgenic, antiandrogenic, and antiestrogenic properties of tanshinone IIA were analyzed in a yeast reporter gene assay. The effects of tanshinone IIA on proliferation and cell cycle distribution were investigated in ERα positive T47D breast cancer cells. The ability of tanshinone IIA to stimulate estrogen receptor-mediated myotube hypertrophy was studied in C2C12 myoblastoma cells. Our data show that tanshinone IIA is quite potent at stimulating ERα and ERβ reporter genes with comparable efficacy. Tanshinone IIA displayed antiestrogenic and also antiandrogenic properties in a yeast reporter gene assay. It inhibited the growth of T47D breast cancer cells by suppressing proliferation and arresting the cells in G0/G1. Tanshinone IIA also stimulated the hypertrophy of C2C12 myotubes via an estrogen receptor-mediated mechanism.
    CONCLUSIONS:
    Summarizing our results, tanshinone IIA can be characterized as an estrogen receptor partial agonist with antiandrogenic properties. It seems to inhibit ERα-mediated cell proliferation but induces ERβ-related biological responses like hypertrophy of myotubes. These findings are interesting with respect to the treatment of a variety of complains of postmenopausal females, including muscle wasting.
    Eur J Pharmacol. 2007 Jul 30;568(1-3):213-21.
    Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis.[Pubmed: 17537428]
    Tanshinone IIA (tan), a derivative of phenanthrenequinone, is one of the key components of Salvia miltiorrhiza Bunge. Previous reports showed that tan inhibited the apoptosis of cultured PC12 cells induced by serum withdrawal or ethanol. However, whether tan has a cardioprotective effect against apoptosis remains unknown.
    METHODS AND RESULTS:
    In this study, we investigated the effects of tan on cardiac myocyte apoptosis induced both by in vitro incubation of neonatal rat ventricular myocytes with H(2)O(2) and by in vivo occlusion followed by reperfusion of the left anterior descending coronary artery in adult rats. In vitro, as revealed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay, treatment with tan prior to H(2)O(2) exposure significantly increased cell viability. Tan also markedly inhibited H(2)O(2)-induced cardiomyocyte apoptosis, as detected by ladder-pattern fragmentation of genomic DNA, chromatin condensation, and hypodioloid DNA content. In vivo, tan significantly inhibited ischemia/reperfusion-induced cardiomyocyte apoptosis by attenuating morphological changes and reducing the percentage of terminal transferase dUTP nick end-labeling (TUNEL)-positive myocytes and caspase-3 cleavage. These effects of tan were associated with an increased ratio of Bcl-2 to Bax protein in cardiomyocytes, an elevation of serum superoxide dismutase (SOD) activity and a decrease in serum malondialdehyde (MDA) level.
    CONCLUSIONS:
    Taken together, these data for the first time provide convincing evidence that tan protects cardiac myocytes against oxidative stress-induced apoptosis. The in vivo protection is mediated by increased scavenging of oxygen free radicals, prevention of lipid peroxidation and upregulation of the Bcl-2/Bax ratio.
    In vivo:
    J Neurol Sci. 2015 Jan 15;348(1-2):142-52.
    Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson's disease.[Pubmed: 25491263 ]
    Tanshinone IIA is one of the major constituents of Salvia miltiorrhiza Bunge known as Danshen. Recent reports have shown that Tanshinone IIA has neuroprotective effects against cerebral ischemia/reperfusion injury and traumatic injury of the spinal cord in rats. However, whether Tanshinone IIA has any neuroprotective effect in Parkinson's disease remains unknown.
    METHODS AND RESULTS:
    In this study, we evaluated whether Tanshinone IIA promotes the survival of nigrostriatal dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. MPTP induced degeneration of nigrostriatal DA neurons and microglial activation as visualized by tyrosine hydroxylase and CD11b immunoreactivity. The results of Western blot and immunohistochemistry showed upregulation of NADPH oxidase and iNOS in the MPTP-treated substantia nigra pars compacta. Treatment with Tanshinone IIA prevented degeneration of nigrostriatal DA neurons and increased the level of striatal dopamine content. This neuroprotection afforded by Tanshinone IIA was associated with the suppression of microglial activation and reduced expression of NADPH oxidase and iNOS.
    CONCLUSIONS:
    The present findings show that Tanshinone IIA may possess anti-inflammatory and anti-oxidative properties and may have therapeutic value in the treatment of Parkinson's disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3967 mL 16.9837 mL 33.9674 mL 67.9348 mL 84.9185 mL
    5 mM 0.6793 mL 3.3967 mL 6.7935 mL 13.587 mL 16.9837 mL
    10 mM 0.3397 mL 1.6984 mL 3.3967 mL 6.7935 mL 8.4918 mL
    50 mM 0.0679 mL 0.3397 mL 0.6793 mL 1.3587 mL 1.6984 mL
    100 mM 0.034 mL 0.1698 mL 0.3397 mL 0.6793 mL 0.8492 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去氢丹参酮IIA; 1,2-Didehydrotanshinone IIA CFN92165 119963-50-7 C19H16O3 = 292.3 5mg QQ客服:2932563308
    丹参酮IIA; Tanshinone IIA CFN98952 568-72-9 C19H18O3 = 294.4 20mg QQ客服:2932563308
    羟基丹参酮IIA; Hydroxytanshinone IIA CFN90353 18887-18-8 C19H18O4 = 310.35 5mg QQ客服:1148253675
    紫丹参酮甲; Przewaquinone A CFN92022 76843-23-7 C19H18O4 = 310.4 5mg QQ客服:2159513211
    3alpha-羟基丹参酮IIA; 3alpha-Hydroxytanshinone IIA CFN90352 97399-71-8 C19H18O4 = 310.35 5mg QQ客服:2159513211
    丹参酮IIB; Tanshinone IIB CFN99820 17397-93-2 C19H18O4 = 310.4 5mg QQ客服:2932563308
    丹参酸甲酯; Methyltanshinonate CFN92148 18867-19-9 C20H18O5 = 338.4 5mg QQ客服:2159513211
    丹参酮IIA磺酸钠; Sulfotanshinone IIA Sodium CFN99162 N/A C19H17NaO6S = 396.39 20mg QQ客服:1148253675

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