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  • 丹参酮I

    Tanshinone I

    丹参酮I
    产品编号 CFN98953
    CAS编号 568-73-0
    分子式 = 分子量 C18H12O3 = 276.3
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    丹参酮I CFN98953 568-73-0 10mg QQ客服:3257982914
    丹参酮I CFN98953 568-73-0 20mg QQ客服:3257982914
    丹参酮I CFN98953 568-73-0 50mg QQ客服:3257982914
    丹参酮I CFN98953 568-73-0 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Gyeongsang National University (Korea)
  • University of Ioannina (Greece)
  • University of Liège (Belgium)
  • Universite Libre de Bruxelles (Belgium)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Deutsches Krebsforschungszentrum (Germany)
  • The Institute of Cancer Research (United Kingdom)
  • Uniwersytet Gdański (Poland)
  • Kamphaengphet Rajabhat University (Thailand)
  • Max-Planck-Insitut (Germany)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Georgia Institute of Technology (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • J Chromatogr A.2017, 1518:46-58
  • J Ethnopharmacol.2017, 196:75-83
  • J Ethnopharmacol.2017, 198:87-90
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • J of L. Chroma.&Related Tech2017, 252-258
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Pharmacol Rep.2017, 69(6):1224-1231
  • ACS Nano.2018, 12(4):3385-3396
  • Molecules.2018, 23(3):E615
  • Chemistry of Natural Compounds2018, 54(3):572–576
  • Front Immunol.2018, 9:2091
  • BMC Complement Altern Med.2019, 19(1):339
  • Molecules.2019, 24(22):E4022
  • Chem Biol Interact.2019, 298:1-7
  • Journal of Apiculture2019, 34(2):131-136
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Int Immunopharmacol.2019, 71:22-31
  • Front Plant Sci.2020, 10:1705
  • Nutrients2020, 12(2):488
  • ...
  • 生物活性
    Description: Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM). Tanshinone I possesses hepatocyte protective, anticancer, neuroprotection, and nephroprotective properties. Tanshinone I pretreatment causes significant suppression of skin cell death induces by solar simulated UV and riboflavin-sensitized UVA.
    Targets: NO | IL Receptor | TNF-α | COX | NF-kB | P450 (e.g. CYP17) | ERK | Nrf2 | p53 | p21 | Bcl-2/Bax | Caspase | Wnt/β-catenin | GSK-3 | sPLA2
    In vitro:
    Fitoterapia. 2015 Mar;101:162-8.
    Tanshinone I induces cyclin D1 proteasomal degradation in an ERK1/2 dependent way in human colorectal cancer cells.[Pubmed: 25615593]
    Tanshinone I (TAN I) as one of the naturally occurring diterpenes from Salvia miltiorrhizae Bunge (Danshen) has been reported to exhibit an anti-cancer activity. However, the underlying mechanisms are still poorly understood. Thus, we performed in vitro study to elucidate the biological mechanism by which TAN I may induce the inhibition of cell growth in human colorectal cancer cells.
    METHODS AND RESULTS:
    The treatment of TAN I suppressed the cell proliferation in HCT116 and SW480 cells and decreased the level of cyclin D1 protein. However, the mRNA level of cyclin D1 did not changed by TAN I treatment. Inhibition of proteasomal degradation by MG132 blocked TAN I-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with TAN I. In addition, phosphorylation of cyclin D1 at threonine-286 was increased by TAN I and a point mutation of threonine-286 to alanine attenuated TAN I-mediated cyclin D1 downregulation. Inhibition of ERK1/2 suppressed cyclin D1 phosphorylation and subsequent downregulation by TAN I. From these results, we suggest that TAN I-mediated cyclin D1 downregulation may result from proteasomal degradation through its ERK1/2-mediated phosphorylation of threonine-286.
    CONCLUSIONS:
    In conclusion, the current study provides new mechanistic link between TAN I, cyclin D1 downregulation and cell growth in human colorectal cancer cells.
    In vivo:
    J Ethnopharmacol. 2015 Apr 22;164:247-55.
    Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson's disease.[Pubmed: 25666429]
    Radix Salviae Miltiorrhizae, known as Danshen, is a well-known traditional Chinese herb which has been used extensively for the treatment of various diseases, including cardiovascular and cerebrovascular disease and neurodegenerative diseases for thousands of years. Tanshinone I is one of major bioactive flavonoids of Radix Salviae Miltiorrhizae. Modulation of microglial over-reaction may represent a therapeutic target to alleviate the progression of neurodegenerative diseases. Here, we tested the effect of Tanshinone I on neuro-inflammation and whether it can provide neuroprotection through inhibition of neuro-inflammation.
    METHODS AND RESULTS:
    The effects of Tanshinone I on the production and/or mRNA expression of pro-inflammatory and anti-inflammatory factors in lipopolysaccharide(LPS)-induced BV-2 microglia cells were tested by Griess reaction, enzyme-linked immunosorbent assay (Elisa) or real time polymerase chain reaction. Activation of nuclear factor κ B (NF-κB) was measured by the nuclear translocation p65 and DNA binding activity. A model of Parkinson׳s disease was established by treatment of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6 mice. The effect of Tanshinone I on the behavioral changes, dopamine and its metabolites levels, expression of tyrosine hydroxylase (TH) and IBA-1, production of cytokines in the midbrain were investigated by the rotarod test, high-performance liquid chromatography (HPLC)-ECD, immunohistochemistry and Elisa. 1-methyl-4-phenylpyridinium (MPP+) concentration was tested by HPLC. Liver toxicity was determined by biochemical assay and histochemistry. We found that the productions and/or expressions of several pro-inflammatory M1 factors such as nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-6 were highly suppressed by Tanshinone I in LPS-induced microglia. Interestingly, it did not affect the enhancement of expression of some anti-inflammatory M2 microglia markers, including IL-10, IL-1 receptor antagonist (IL-1Ra) and Cox-2. But it could significantly inhibit LPS-induced granulocyte colony-stimulating factor (G-CSF) expression. Tanshinone I could also inhibit LPS-induced NF-κB activation in microglia. Furthermore, it improved motor functions, normalized striatal neurotransmitters, and provided dopaminergic neuronal protection in MPTP-intoxicated mice. In vivo results also indicated that Tanshinone I could modulate MPTP-induced microglial activation, attenuated the increase of TNF-α, reserved the increase of IL-10 concentrain of MPTP-intoxicated mice. Tanshinone I does not alter MPTP toxic metabolite (MPP+) concentration. Oral administration of Tanshinone I at 10mg/kg daily for 2 weeks did not show liver toxicity.
    CONCLUSIONS:
    Tanshinone I selectively suppressed pro-inflammatory M1 genes expression in activated microglia, interestingly, partially reserved anti-inflammatory M2 genes expression. It also could provide neuroprotection in a mouse model of Parkinson׳s disease. These data indicated that Tanshinone I could make the most of the beneficial side and minimize the detrimental side of activated microglia simultaneously, and provide neuroprotection by modulating the immune response of microglia.
    Environ Toxicol Pharmacol. 2013 Nov;36(3):850-7.
    Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A.[Pubmed: 23981375]
    Hepatic CYP1A especially CYP1A2 plays an important role in the reduction of aristolochic acid I (AAI) nephrotoxicity.
    METHODS AND RESULTS:
    In this study, we investigated the effects of tanshinone I, a strong inducer of Cyp1a, on the nephrotoxicity induced by AAI. Histopathology and blood biochemistry assays showed that tanshinone I could reduce AAI-induced acute kidney injury. Pharmacokinetics analysis revealed that tanshinone I markedly decreased AUC of AAI in plasma and the content of AAI in both liver and kidney, indicating the enhancement of AAI metabolism. Real-time PCR and Western blot analysis confirmed that tanshinone I effectively increased the mRNA and protein levels of hepatic CYP1A1 and CYP1A2 in vivo. Luciferase assay showed that tanshinone I strongly increased the transcriptional activity of CYP1A1 and CYP1A2 in the similar extent.
    CONCLUSIONS:
    In summary, our data suggested that tanshinone I facilitated the metabolism of AAI and prevented AAI-induced kidney injury by induction of hepatic CYP1A 1/2 in vivo.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6193 mL 18.0963 mL 36.1925 mL 72.3851 mL 90.4814 mL
    5 mM 0.7239 mL 3.6193 mL 7.2385 mL 14.477 mL 18.0963 mL
    10 mM 0.3619 mL 1.8096 mL 3.6193 mL 7.2385 mL 9.0481 mL
    50 mM 0.0724 mL 0.3619 mL 0.7239 mL 1.4477 mL 1.8096 mL
    100 mM 0.0362 mL 0.181 mL 0.3619 mL 0.7239 mL 0.9048 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    丹参二醇A; Tanshindiol A CFN92145 97411-46-6 C18H16O5 = 312.3 5mg QQ客服:2932563308
    丹参内酯; Tanshinlactone CFN99072 105351-70-0 C17H12O3 = 264.3 5mg QQ客服:215959384
    甘西鼠尾新酮A; Neoprzewaquinone A CFN97087 630057-39-5 C36H28O6 = 556.6 5mg QQ客服:2159513211
    3-羟基亚甲基丹参醌; 3-Hydroxymethylenetanshinquinone CFN90348 83145-47-5 C18H14O4 = 294.30 5mg QQ客服:2932563308
    1,2-二氢丹参醌; 1,2-Dihydrotanshinquinone CFN90333 77769-21-2 C18H14O3 = 278.3 5mg QQ客服:3257982914
    丹参酮I; Tanshinone I CFN98953 568-73-0 C18H12O3 = 276.3 20mg QQ客服:2159513211
    Isosalviamine A; Isosalviamine A CFN92645 878475-29-7 C19H13NO2 = 287.3 5mg QQ客服:2159513211
    Isosalviamine B; Isosalviamine B CFN92646 878475-30-0 C20H15NO2 = 301.3 5mg QQ客服:1413575084
    丹参醇B; Tanshinol B CFN90370 189290-30-0 C18H16O4 = 296.32 5mg QQ客服:1413575084
    紫丹参素C; Przewaquinone C CFN92021 96839-29-1 C18H16O4 = 296.3 5mg QQ客服:2932563308

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