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  • 丹参二醇C

    Tanshindiol C

    丹参二醇C
    产品编号 CFN92147
    CAS编号 97465-71-9
    分子式 = 分子量 C18H16O5 = 312.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    丹参二醇C CFN92147 97465-71-9 1mg QQ客服:2159513211
    丹参二醇C CFN92147 97465-71-9 5mg QQ客服:2159513211
    丹参二醇C CFN92147 97465-71-9 10mg QQ客服:2159513211
    丹参二醇C CFN92147 97465-71-9 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chang Gung University (Taiwan)
  • Ateneo de Manila University (Philippines)
  • Universidade de Franca (Brazil)
  • Kamphaengphet Rajabhat University (Thailand)
  • Chulalongkorn University (Thailand)
  • Gyeongsang National University (Korea)
  • Celltrion Chemical Research Institute (Korea)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Hertfordshire (United Kingdom)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Tohoku University (Japan)
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  • Indian Institute of Science (India)
  • Florida A&M University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Appl. Sci.2020, 10,1304
  • J Sep Sci.2020, 43(22):4148-4161.
  • Mol Cells.2015, 38(9):765-72
  • Environ Toxicol.2021, 36(9):1848-1856.
  • J.of Traditional&Complementary Med.2022, 10.1016:j.jtcme.
  • Molecules.2018, 23(7):E1659
  • University of Guelph2021, 12.
  • Phytother Res.2022, 10.1002:ptr.7602.
  • Appl. Sci.2020, 10(20),7374.
  • Front. Physiol.2022, 790345.
  • Nutrients.2019, 11(11):E2694
  • Nutr Cancer.2022, 1-13.
  • Molecules2022, 27(12):3903.
  • Sci Rep.2018, 8(1)
  • Evid-Based Compl Alt2020, 7202519:13
  • J Ethnopharmacol.2022, 282:114574.
  • Foods. 2022, 11(23):3905.
  • J Cell Mol Med.2023, jcmm.17968.
  • Phytomedicine.2022, 96:153877.
  • SBRAS2016, 12
  • South African Journal of Botany2021, 142:114-123.
  • J Cell Physiol.2021, 236(3):1950-1966.
  • Int J Cosmet Sci.2023, 45(2):155-165.
  • ...
  • 生物活性
    Description: Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therapeutic intervention of atherosclerosis.It possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information for designing a new class of potent EZH2 inhibitors.
    Targets: LDL | EZH2 | Prdx1 | ABCA
    In vitro:
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 1864(3):882-890.
    Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via peroxiredoxin 1 dependent pathway.[Reference: WebLink]
    NF-E2-related factor 2 (Nrf2) has been shown to be protective in atherosclerosis. The loss of Nrf2 in macrophages enhances foam cell formation and promotes early atherogenesis. Tanshindiol C (Tan C) is isolated from the root of Salvia miltiorrhiza Bge., a traditional Chinese medicine that has been used for the treatment of several cardiovascular diseases for many years. This study was aimed to test the potential role of Tan C against macrophage foam cell formation and to explore the underlying mechanism.
    METHODS AND RESULTS:
    Firstly, we observed that Tan C markedly suppressed oxidized low-density lipoprotein (oxLDL) induced macrophage foam cell formation. Then, we found that Tan C was an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. Nrf2 and Sirt1 synergistically activated the transcription of anti-oxidant peroxiredoxin 1 (Prdx1) after Tan C treatment. More important, we demonstrated that silencing of Prdx1 promoted oxLDL-induced macrophage foam cell formation. Prdx1 upregulated adenosine triphosphate-binding cassette (ABC) transporter A1 (ABCA1) expression and decreased intracellular lipid accumulation. Furthermore, Tan C ameliorated oxLDL induced macrophage foam cell formation in a Prdx1-dependent manner.
    CONCLUSIONS:
    These observations suggest that Tan C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therapeutic intervention of atherosclerosis.
    Bioorganic & Medicinal Chemistry Letters, 2014, 24(11):2486-2492.
    Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors.[Reference: WebLink]
    EZH2 is the core subunit of Polycomb repressive complex 2 catalyzing the methylation of histone H3 lysine-27 and closely involved in tumorigenesis.
    METHODS AND RESULTS:
    To discover small molecule inhibitors for EZH2 methyltransferase activity, we performed an inhibitor screen with catalytically active EZH2 protein complex and identified tanshindiols as EZH2 inhibitors. Tanshindiol B and Tanshindiol C potently inhibited the methyltransferase activity in in vitro enzymatic assay with IC50 values of 0.52 μM and 0.55 μM, respectively. Tanshindiol C exhibited growth inhibition of several cancer cells including Pfeiffer cell line, a diffuse large B cell lymphoma harboring EZH2 A677G activating mutation. Tanshindiol treatment in Pfeiffer cells significantly decreased the tri-methylated form of histone H3 lysine-27, a substrate of EZH2, as revealed by Western blot analysis and histone methylation ELISA. Based on enzyme kinetics and docking studies, we propose that tanshindiol-mediated inhibition of EZH2 activity is competitive for the substrate S-adenosylmethionine.
    CONCLUSIONS:
    Taken together, our findings strongly suggest that tanshindiols possess a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information for designing a new class of potent EZH2 inhibitors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.202 mL 16.0102 mL 32.0205 mL 64.041 mL 80.0512 mL
    5 mM 0.6404 mL 3.202 mL 6.4041 mL 12.8082 mL 16.0102 mL
    10 mM 0.3202 mL 1.601 mL 3.202 mL 6.4041 mL 8.0051 mL
    50 mM 0.064 mL 0.3202 mL 0.6404 mL 1.2808 mL 1.601 mL
    100 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘西鼠尾新酮A; Neoprzewaquinone A CFN97087 630057-39-5 C36H28O6 = 556.6 5mg QQ客服:2056216494
    3-羟基亚甲基丹参醌; 3-Hydroxymethylenetanshinquinone CFN90348 83145-47-5 C18H14O4 = 294.30 5mg QQ客服:1457312923
    1,2-二氢丹参醌; 1,2-Dihydrotanshinquinone CFN90333 77769-21-2 C18H14O3 = 278.3 5mg QQ客服:3257982914
    丹参酮I; Tanshinone I CFN98953 568-73-0 C18H12O3 = 276.3 20mg QQ客服:215959384
    Isosalviamine A; Isosalviamine A CFN92645 878475-29-7 C19H13NO2 = 287.3 5mg QQ客服:3257982914
    Isosalviamine B; Isosalviamine B CFN92646 878475-30-0 C20H15NO2 = 301.3 5mg QQ客服:1413575084
    丹参醇B; Tanshinol B CFN90370 189290-30-0 C18H16O4 = 296.32 5mg QQ客服:2159513211
    紫丹参素C; Przewaquinone C CFN92021 96839-29-1 C18H16O4 = 296.3 5mg QQ客服:2159513211
    丹参二醇B; Tanshindiol B CFN92146 97465-70-8 C18H16O5 = 312.3 5mg QQ客服:1413575084
    丹参二醇C; Tanshindiol C CFN92147 97465-71-9 C18H16O5 = 312.3 5mg QQ客服:1457312923

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