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  • 斯皮诺素

    Spinosin

    斯皮诺素
    产品编号 CFN99600
    CAS编号 72063-39-9
    分子式 = 分子量 C28H32O15 = 608.55
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The seeds of Ziziphus jujuba
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    斯皮诺素 CFN99600 72063-39-9 10mg QQ客服:1148253675
    斯皮诺素 CFN99600 72063-39-9 20mg QQ客服:1148253675
    斯皮诺素 CFN99600 72063-39-9 50mg QQ客服:1148253675
    斯皮诺素 CFN99600 72063-39-9 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of British Columbia (Canada)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Indian Institute of Science (India)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Sapienza University of Rome (Italy)
  • Donald Danforth Plant Science Center (USA)
  • St. Jude Children Research Hospital (USA)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Technical University of Denmark (Denmark)
  • University of Toronto (Canada)
  • Seoul National University (Korea)
  • Mendel University in Brno (Czech Republic)
  • Chungnam National University (Korea)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Phytother Res.2015, 29(7):1088-96
  • FEBS Lett.2015, 589(1):182-7
  • Nat Prod Sci.2016, 22(2)
  • Tea Res. Ins. Of China2017, 1-12
  • PLoS One.2017, 12(3):e0173585
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Molecules.2017, 22(3)
  • Srinagarind Medical Journal2017, 32(1)
  • LWT-Food Science and Technology2017, 75:488-496
  • Int J Biol Macromol.2018, 112:1093-1103
  • Mol Pharm.2018, 15(8):3285-3296
  • J Pharm Biomed Anal.2018, 151:32-41
  • BMC Complement Altern Med.2018, 18(1):221
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Anticancer Res.2018, 38(4):2127-2135
  • Front Pharmacol.2019, 10:1355
  • Front Microbiol.2019, 10:2806
  • Front Neurosci.2019, 13:1091
  • Srinagarind Medical Journal2019, 34(1)
  • Int J Mol Med.2019, 43(6):2516-2522
  • TCI CO.2019, US20190151281A1
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • ...
  • 生物活性
    Description: Spinosin has neuroprotective, anxiolytic-like and anti-inflammatory effects, it ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, it also potentiated pentobarbital-induced sleep via the serotonergic system.
    Targets: Beta Amyloid | 5-HT Receptor | cAMP | ERK | GABA Receptor
    In vivo:
    Biomol Ther (Seoul). 2015 Mar;23(2):156-64.
    Spinosin, a C-Glucosylflavone, from Zizyphus jujuba var. spinosa Ameliorates Aβ1-42 Oligomer-Induced Memory Impairment in Mice.[Pubmed: 25767684]
    Alzheimer's disease (AD) is a neurodegenerative disorder associated with progressive memory loss and neuronal cell death. Although numerous previous studies have been focused on disease progression or reverse pathological symptoms, therapeutic strategies for AD are limited. Alternatively, the identification of traditional herbal medicines or their active compounds has received much attention. The aims of the present study were to characterize the ameliorating effects of spinosin, a C-glucosylflavone isolated from Zizyphus jujuba var. spinosa, on memory impairment or the pathological changes induced through amyloid-β1-42 oligomer (AβO) in mice.
    METHODS AND RESULTS:
    Memory impairment was induced by intracerebroventricular injection of AβO (50 μM) and spinosin (5, 10, and 20 mg/kg) was administered for 7 days. In the behavioral tasks, the subchronic administration of spinosin (20 mg/kg, p.o.) significantly ameliorated AβO-induced cognitive impairment in the passive avoidance task or the Y-maze task. To identify the effects of spinosin on the pathological changes induced through AβO, immunohistochemistry and Western blot analyses were performed. Spinosin treatment also reduced the number of activated microglia and astrocytes observed after AβO injection. In addition, spinosin rescued the AβO-induced decrease in choline acetyltransferase expression levels.
    CONCLUSIONS:
    These results suggest that spinosin ameliorated memory impairment induced through AβO, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammatory effects of spinosin. Therefore, spinosin might be a useful agent against the amyloid b protein-induced cognitive dysfunction observed in AD patients.
    Pharmacol Biochem Behav. 2014 May;120:88-94.
    Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice.[Pubmed: 24582850]
    Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var. spinosa.
    METHODS AND RESULTS:
    This study investigated the effect of spinosin on cholinergic blockade-induced memory impairment in mice. Behavioral tests were conducted using the passive avoidance, Y-maze, and Morris water maze tasks to evaluate the memory-ameliorating effect of spinosin. Spinosin (10 or 20mg/kg, p.o.) significantly ameliorated scopolamine-induced cognitive impairment in these behavioral tasks with a prolonged latency time in the passive avoidance task, an increased percentage of spontaneous alternation in the Y-maze task and a lengthened swimming time in target quadrant in the Morris water maze task. In addition, a single administration of spinosin in normal naïve mice also enhanced the latency time in the passive avoidance task. To identify the mechanism of the memory-ameliorating effect of spinosin, receptor antagonism analysis and Western blotting were performed. The ameliorating effect of spinosin on scopolamine-induced memory impairment was significantly antagonized by a sub-effective dose (0.5mg/kg, i.p.) of 8-hydroxy-2-(di-N-propylamino)tetralin, a 5-HT1A receptor agonist. In addition, spinosin significantly increased the expression levels of phosphorylated extracellular signal-regulated kinases and cAMP response element-binding proteins in the hippocampus.
    CONCLUSIONS:
    Taken together, these results indicate that the memory-ameliorating effect of spinosin may be, in part, due to the serotonergic neurotransmitter system, and that spinosin may be useful for the treatment of cognitive dysfunction in diseases such as Alzheimer's disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6433 mL 8.2163 mL 16.4325 mL 32.865 mL 41.0813 mL
    5 mM 0.3287 mL 1.6433 mL 3.2865 mL 6.573 mL 8.2163 mL
    10 mM 0.1643 mL 0.8216 mL 1.6433 mL 3.2865 mL 4.1081 mL
    50 mM 0.0329 mL 0.1643 mL 0.3287 mL 0.6573 mL 0.8216 mL
    100 mM 0.0164 mL 0.0822 mL 0.1643 mL 0.3287 mL 0.4108 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    维采宁-2; Vicenin -2 CFN92031 23666-13-9 C27H30O15 = 594.5 10mg QQ客服:1413575084
    异牡荆黄素 2''-O-阿拉伯糖苷; Isovitexin 2''-O-arabinoside CFN90943 53382-71-1 C26H28O14 = 564.49 10mg QQ客服:215959384
    6''-O-乙酰基异牡荆黄素; 6''-O-acetylisovitexin CFN99341 1223097-20-8 C23H22O11 = 474.4 5mg QQ客服:3257982914
    Meloside A; Meloside A CFN90132 60767-80-8 C27H30O15 = 594.52 5mg QQ客服:1148253675
    异肥皂草苷; Isosaponarin CFN90133 19416-87-6 C27H30O15 = 594.52 5mg QQ客服:1413575084
    王不留行黄酮苷; Vaccarin CFN90131 53452-16-7 C32H38O19 = 726.64 20mg QQ客服:215959384
    皂草苷; 皂草黄苷; Saponarin CFN90134 20310-89-8 C27H30O15 = 594.52 5mg QQ客服:2159513211
    当药黄素; Swertisin CFN90621 6991-10-2 C22H22O10 = 446.4 10mg QQ客服:2159513211
    斯皮诺素; Spinosin CFN99600 72063-39-9 C28H32O15 = 608.55 20mg QQ客服:3257982914
    6'''-阿魏酰斯皮诺素; 6'''-Feruloylspinosin CFN90665 77690-92-7 C38H40O18 = 784.71 20mg QQ客服:3257982914

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