Info: Read More
  • 中药标准品生产商,产品定制服务
  • 斯皮诺素

    Spinosin

    斯皮诺素
    产品编号 CFN99600
    CAS编号 72063-39-9
    分子式 = 分子量 C28H32O15 = 608.55
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The seeds of Ziziphus jujuba
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    斯皮诺素 CFN99600 72063-39-9 10mg QQ客服:2056216494
    斯皮诺素 CFN99600 72063-39-9 20mg QQ客服:2056216494
    斯皮诺素 CFN99600 72063-39-9 50mg QQ客服:2056216494
    斯皮诺素 CFN99600 72063-39-9 100mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • MTT Agrifood Research Finland (Finland)
  • Tokyo Woman's Christian University (Japan)
  • Universidade Federal de Santa Catarina (Brazil)
  • Universidad Veracuzana (Mexico)
  • Universidade da Beira Interior (Germany)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Biotech R&D Institute (USA)
  • Universidade Católica Portuguesa (Portugal)
  • Semmelweis Unicersity (Hungary)
  • Weizmann Institute of Science (Israel)
  • Center for protein Engineering (CIP) (Belgium)
  • Aveiro University (Portugal)
  • Melbourne University (Australia)
  • University of Hertfordshire (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(2):329
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • Int J Mol Sci.2020, 21(9):3239.
  • J Cell Mol Med . 2023, jcmm.17954.
  • Mol Biol Rep.2022, doi: 10.1007
  • Int. J. Mol. Sci.2022, 23(14),7699;
  • J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
  • Chem Biol Interact.2016, 260:168-175
  • Eur J Pharmacol.2018, 832:96-103
  • CZECH MYCOLOGY2021, 73(1):1-19.
  • Food Chem.2023, 404(Pt A):134517.
  • International. J. of Food Properties 2017, 20:S131-S140
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • Sci Rep. 2018, 462(8)
  • Heliyon.2022, 8(12):e12031.
  • Front Plant Sci.2017, 8:723
  • Molecules.2022, 27(19):6681.
  • Food Research2021, 5(1):65-71
  • Toxicol Mech Methods.2021, 1-12.
  • J Ethnopharmacol.2022, 289:115018.
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • JPC-Journal of Planar Chromatography2023, 36:179-190
  • J Sci Food Agric.2022, 102(4):1628-1639
  • ...
  • 生物活性
    Description: Spinosin has neuroprotective, anxiolytic-like and anti-inflammatory effects, it ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, it also potentiated pentobarbital-induced sleep via the serotonergic system.
    Targets: Beta Amyloid | 5-HT Receptor | cAMP | ERK | GABA Receptor
    In vitro:
    Biomol Ther (Seoul) . 2019 Jan 1;27(1):71-77.
    Neuroprotective Effects of Spinosin on Recovery of Learning and Memory in a Mouse Model of Alzheimer's Disease[Pubmed: 29925225]
    Abstract Previous studies have shown that spinosin was implicated in the modulation of sedation and hypnosis, while its effects on learning and memory deficits were rarely reported. The aim of this study is to investigate the effects of spinosin on the improvement of cognitive impairment in model mice with Alzheimer's disease (AD) induced by Aβ₁₋₄₂ and determine the underlying mechanism. Spontaneous locomotion assessment and Morris water maze test were performed to investigate the impact of spinosin on behavioral activities, and the pathological changes were assayed by biochemical analyses and histological assay. After 7 days of intracerebroventricular (ICV) administration of spinosin (100 μg/kg/day), the cognitive impairment of mice induced by Aβ₁₋₄₂ was significantly attenuated. Moreover, spinosin treatment effectively decreased the level of malondialdehyde (MDA) and Aβ₁₋₄₂ accumulation in hippocampus. Aβ₁₋₄₂ induced alterations in the expression of brain derived neurotrophic factor (BDNF) and B-cell lymphoma-2 (Bcl-2), as well as inflammatory response in brain were also reversed by spinosin treatment. These results indicated that the ameliorating effect of spinosin on cognitive impairment might be mediated through the regulation of oxidative stress, inflammatory process, apoptotic program and neurotrophic factor expression, suggesting that spinosin might be beneficial to treat learning and memory deficits in patients with AD via multi-targets. Keywords: Alzheimer’s disease; Neuroprotection; Semen Ziziphi spinosae; Spinosin.
    In vivo:
    Biomol Ther (Seoul). 2015 Mar;23(2):156-64.
    Spinosin, a C-Glucosylflavone, from Zizyphus jujuba var. spinosa Ameliorates Aβ1-42 Oligomer-Induced Memory Impairment in Mice.[Pubmed: 25767684]
    Alzheimer's disease (AD) is a neurodegenerative disorder associated with progressive memory loss and neuronal cell death. Although numerous previous studies have been focused on disease progression or reverse pathological symptoms, therapeutic strategies for AD are limited. Alternatively, the identification of traditional herbal medicines or their active compounds has received much attention. The aims of the present study were to characterize the ameliorating effects of spinosin, a C-glucosylflavone isolated from Zizyphus jujuba var. spinosa, on memory impairment or the pathological changes induced through amyloid-β1-42 oligomer (AβO) in mice.
    METHODS AND RESULTS:
    Memory impairment was induced by intracerebroventricular injection of AβO (50 μM) and spinosin (5, 10, and 20 mg/kg) was administered for 7 days. In the behavioral tasks, the subchronic administration of spinosin (20 mg/kg, p.o.) significantly ameliorated AβO-induced cognitive impairment in the passive avoidance task or the Y-maze task. To identify the effects of spinosin on the pathological changes induced through AβO, immunohistochemistry and Western blot analyses were performed. Spinosin treatment also reduced the number of activated microglia and astrocytes observed after AβO injection. In addition, spinosin rescued the AβO-induced decrease in choline acetyltransferase expression levels.
    CONCLUSIONS:
    These results suggest that spinosin ameliorated memory impairment induced through AβO, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammatory effects of spinosin. Therefore, spinosin might be a useful agent against the amyloid b protein-induced cognitive dysfunction observed in AD patients.
    Pharmacol Biochem Behav. 2014 May;120:88-94.
    Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice.[Pubmed: 24582850]
    Spinosin is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujuba var. spinosa.
    METHODS AND RESULTS:
    This study investigated the effect of spinosin on cholinergic blockade-induced memory impairment in mice. Behavioral tests were conducted using the passive avoidance, Y-maze, and Morris water maze tasks to evaluate the memory-ameliorating effect of spinosin. Spinosin (10 or 20mg/kg, p.o.) significantly ameliorated scopolamine-induced cognitive impairment in these behavioral tasks with a prolonged latency time in the passive avoidance task, an increased percentage of spontaneous alternation in the Y-maze task and a lengthened swimming time in target quadrant in the Morris water maze task. In addition, a single administration of spinosin in normal naïve mice also enhanced the latency time in the passive avoidance task. To identify the mechanism of the memory-ameliorating effect of spinosin, receptor antagonism analysis and Western blotting were performed. The ameliorating effect of spinosin on scopolamine-induced memory impairment was significantly antagonized by a sub-effective dose (0.5mg/kg, i.p.) of 8-hydroxy-2-(di-N-propylamino)tetralin, a 5-HT1A receptor agonist. In addition, spinosin significantly increased the expression levels of phosphorylated extracellular signal-regulated kinases and cAMP response element-binding proteins in the hippocampus.
    CONCLUSIONS:
    Taken together, these results indicate that the memory-ameliorating effect of spinosin may be, in part, due to the serotonergic neurotransmitter system, and that spinosin may be useful for the treatment of cognitive dysfunction in diseases such as Alzheimer's disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6433 mL 8.2163 mL 16.4325 mL 32.865 mL 41.0813 mL
    5 mM 0.3287 mL 1.6433 mL 3.2865 mL 6.573 mL 8.2163 mL
    10 mM 0.1643 mL 0.8216 mL 1.6433 mL 3.2865 mL 4.1081 mL
    50 mM 0.0329 mL 0.1643 mL 0.3287 mL 0.6573 mL 0.8216 mL
    100 mM 0.0164 mL 0.0822 mL 0.1643 mL 0.3287 mL 0.4108 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异斯皮诺素; Isospinosin CFN95350 89701-83-7 C28H32O15 = 608.6 5mg QQ客服:1457312923
    芹菜素-6-C-α-L-阿拉伯糖-8-C-β-D-木糖苷; Apigenin 6-C-alpha-L-arabinopyranosyl-8-C-beta-D-xylopyranoside CFN90918 677021-30-6 C25H26O13 = 534.47 5mg QQ客服:2159513211
    芹菜素-6,8-二-C-α-L-吡喃阿拉伯糖苷; Apigenin 6,8-di-C-alpha-L-arabinopyranoside CFN95360 73140-47-3 C25H26O13 = 534.5 10mg QQ客服:3257982914
    维采宁-3; Vicenin -3 CFN92032 59914-91-9 C26H28O14 = 564.5 20mg QQ客服:1413575084
    夏佛塔苷; Schaftoside CFN90197 51938-32-0 C26H28O14 = 564.49 20mg QQ客服:2159513211
    新夏佛托苷; Neoschaftoside CFN92071 61328-41-4 C26H28O14 = 564.5 5mg QQ客服:215959384
    维采宁-1; Vicenin -1 CFN92030 35927-38-9 C26H28O14 = 564.5 20mg QQ客服:1457312923
    伞花耳草苷; Corymboside CFN95292 73543-87-0 C26H28O14 = 564.5 10mg QQ客服:3257982914
    异夏佛塔苷; Isoschaftoside CFN92029 52012-29-0 C26H28O14 = 564.5 20mg QQ客服:3257982914
    维采宁-2; Vicenin -2 CFN92031 23666-13-9 C27H30O15 = 594.5 20mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产