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  • 槐属双苷

    Sophorabioside

    槐属双苷
    产品编号 CFN90958
    CAS编号 2945-88-2
    分子式 = 分子量 C27H30O14 = 578.52
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The seeds of Sophora japonica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    槐属双苷 CFN90958 2945-88-2 1mg QQ客服:2159513211
    槐属双苷 CFN90958 2945-88-2 5mg QQ客服:2159513211
    槐属双苷 CFN90958 2945-88-2 10mg QQ客服:2159513211
    槐属双苷 CFN90958 2945-88-2 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medical University of South Carolina (USA)
  • Universidad Industrial de Santander (Colombia)
  • University of Bordeaux (France)
  • National Cancer Center Research Institute (Japan)
  • Shanghai University of TCM (China)
  • University of Malaya (Malaysia)
  • Ateneo de Manila University (Philippines)
  • University of Illinois (USA)
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  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Medicine and Pharmacy (Romania)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biomedicines.2022, 10(2):463.
  • PLoS One.2018, 13(4):e0195642
  • Molecules.2019, 24(23):E4303
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • J Pain Res.2022, 15:3469-3478.
  • Antioxidants (Basel).2022, 11(12):2496.
  • Histol Histopathol.2022, 18518.
  • J Biomol Struct Dyn.2022, 1-21.
  • Int J Mol Sci.2019, 20(21):E5488
  • Molecules.2019, 24(17):E3127
  • J Med Food.2022, 25(3):272-280.
  • Molecules.2019, 24(12):E2286
  • Antioxidants (Basel).2021, 10(8):1300.
  • APMIS.2019, 127(10):688-695
  • Plant Pathology2022, 13527
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Molecules.2019, 24(16):E3003
  • Molecules2022, 27(9):2827.
  • Pharmaceuticals (Basel).2021, 14(6):588.
  • Chem Biol Interact.2022, 368:110248.
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  • Food Res Int.2020, 133:109130.
  • Applied Biological Chemistry 2022, 65,5(2022).
  • ...
  • 生物活性
    Description: Sophorabioside is a natural product from Sophora japonica.
    In vivo:
    PLoS One. 2014 Jun 3;9(6):e98559.
    Isolation of antiosteoporotic compounds from seeds of Sophora japonica.[Pubmed: 24892557]
    Chemical investigation of Sophora japonica seeds resulted in the isolation of seven metabolites identified as: genistin (1), sophoricoside (2), sophorabioside (3), sophoraflavonoloside (4), genistein 7,4'-di-O-β-D-glucopyransoide (5), kaempferol 3-O-α-L-rhamnopyranosyl(1 → 6)β-D-glucopyranosyl(1 → 2)β-D-glucopyranoside (6) and rutin (7).
    METHODS AND RESULTS:
    Compounds 1, 2 and 5 showed significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range. Compounds 1 and 2 showed minimal cell membrane damaging effect using LDH leakage assay. Accordingly, compound 2 (sophoricoside, (SPH)) was selected for further in-vivo studies as a potential anti-osteoporosis agent. The anti-osteoporotic effect of SPH was assessed in ovarectomized (OVX) rats after oral administration (15 mg/kg and 30 mg/kg) for 45 days compared to estradiol (10 µg/kg) as a positive control. Only in a dose of 30 mg/kg, SPH regained the original mechanical bone hardness compared to normal non-osteoporotic group. However, SPH (15 mg/kg) significantly increased the level of alkaline phosphatase (ALP) to normal level. Treatment with SPH (30 mg/kg) increased the level of ALP to be higher than normal group. SPH (15 mg/kg) did not significantly increase the serum level of osteocalcin (OC) compared to OVX group. On the other hand, treatment with SPH (30 mg/kg) significantly increased the level of OC to 78% higher than normal non-ovarectomized animals group. In addition, SPH (15 mg/kg) decreased the bone resorption marker, acid phosphatase (ACP) to normal level and SPH (30 mg/kg) further diminished the level of serum ACP.
    CONCLUSIONS:
    Histopathologically, sophoricoside ameliorated the ovarectomy induced osteoporosis in a dose dependent manner. The drug showed thicker bony trabeculae, more osteoid, and more osteoblastic rimming compared to OVX group.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7285 mL 8.6427 mL 17.2855 mL 34.571 mL 43.2137 mL
    5 mM 0.3457 mL 1.7285 mL 3.4571 mL 6.9142 mL 8.6427 mL
    10 mM 0.1729 mL 0.8643 mL 1.7285 mL 3.4571 mL 4.3214 mL
    50 mM 0.0346 mL 0.1729 mL 0.3457 mL 0.6914 mL 0.8643 mL
    100 mM 0.0173 mL 0.0864 mL 0.1729 mL 0.3457 mL 0.4321 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3'-甲氧基葛根素芹菜糖苷; 3'-Methoxymirificin CFN95112 1297609-29-0 C27H30O14 = 578.5 5mg QQ客服:2056216494
    Butesuperin B-7''-O-beta-glucopyranoside; Butesuperin B-7''-O-beta-glucopyranoside CFN95502 N/A C33H34O14 = 654.6 5mg QQ客服:3257982914
    4'-O-甲氧基葛根素; 4'-Methoxypuerarin CFN90782 92117-94-7 C22H22O9 = 430.4 10mg QQ客服:2056216494
    葛根素-6''-O-木糖苷; Puerarin 6''-O-xyloside CFN90640 114240-18-5 C26H28O13 = 548.49 20mg QQ客服:2056216494
    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside; Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside CFN95157 1147858-78-3 C27H30O13 = 562.5 10mg QQ客服:2056216494
    美佛辛-4'-O-葡萄糖苷; Mirificin-4'-O-glucoside CFN95091 168035-01-6 C32H38O18 = 710.6 5mg QQ客服:2159513211
    3'-羟基葛根素; 3'-Hydroxy Puerarin CFN90236 117060-54-5 C21H20O10 = 432.38 20mg QQ客服:1457312923
    3'-甲氧基葛根素; 3'-Methoxypuerarin CFN90780 117047-07-1 C22H22O10 = 446.4 20mg QQ客服:2159513211
    大豆苷; Daidzin CFN99101 552-66-9 C21H20O9 = 416.38 20mg QQ客服:2159513211
    大豆苷元-7-O-葡萄糖醛酸苷; Daidzein 7-O-glucuronide CFN70352 38482-80-3 C21H18O10 = 430.4 5mg QQ客服:2159513211

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