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    • 黑芥子苷

    Sinigrin

    黑芥子苷
    		产品编号 CFN90453
    CAS编号 3952-98-5
    分子式 = 分子量 C10H16KNO9S2 = 397.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The seeds of Lepidium apetalum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黑芥子苷 CFN90453 3952-98-5 10mg QQ客服：215959384
    黑芥子苷 CFN90453 3952-98-5 20mg QQ客服：215959384
    黑芥子苷 CFN90453 3952-98-5 50mg QQ客服：215959384
    黑芥子苷 CFN90453 3952-98-5 100mg QQ客服：215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Toronto (Canada)
  • Universidade Católica Portuguesa (Portugal)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Univerzita Karlova v Praze (Czech Republic)
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  • Guangzhou Institutes of Biomedicine and Health (China)
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  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Chem Biol Interact.2020, 328:109200.
  • Toxicol Res.2019, 35(4):371-387
  • RSC Advances2017, 86
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • HIV Med.2021, 22(8):690-704.
  • Phytomedicine.2021, 93:153796.
  • South African J of Botany2020, 135:50-57
  • Food Science and Biotechnology2022, 10.1007.
  • Molecules.2020, 25(18),4089.
  • Sci Rep. 2018, 462(8)
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • Int J Mol Sci.2022, 23(21):13112.
  • Planta Med.2016, 82(13):1208-16
  • Phytomedicine.2019, 62:152962
  • Biofactors.2018, 44(2):168-179
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Toxicol In Vitro.2019, 59:161-178
  • Integr Cancer Ther.2018, 17(3):832-843
  • Int J Mol Sci.2019, 21(1):E265
  • Journal of Food Quality2022, P:13, 6256310.
  • Int J Mol Sci.2022, 23(1):538.
  • ...
    • 生物活性
    Description: Sinigrin has antimicrobial activity. Sinigrin also exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats.
    Targets: p53 | Bcl-2/Bax | Caspase | Antifection
    In vitro:
    Lett Appl Microbiol. 2015 May 15.
    Use of a nanoparticulate carboxymethyl cellulose film containing sinigrin as an antimicrobial precursor to kill Escherichia coli O157:H7 on fresh beef.[Pubmed: 25976711]

    METHODS AND RESULTS:
    Nanocomposite carboxymethyl cellulose films containing sinigrin (SNG) were prepared by stirring 2% (w/v) carboxymethyl cellulose (CMC) and 2% (w/v) glycerol (as a plasticizer) in distilled water with or without SNG (an antimicrobial precursor) as a 99% pure reagent (pSNG) or as a crude extract (cSNG). These films plus normal CMC film with or without SNG were tested on Escherichia coli O157:H7- inoculated beef for antimicrobial activity. Beef pieces measuring 6 × 5 × 2 cm(3) (L × W × H) were dipped in an E. coli O157:H7 broth suspension containing >8 log10 CFU ml(-1) and were drained for 3 min over a sterile cloth. They were wrapped in CMC or NCMC films, placed in a high oxygen barrier film (Deli *1), vacuum-packaged and stored at 8°C for 5, 8, 12 and 18 days.
    CONCLUSIONS:
    The CMC and NCMC films without SNG were not antimicrobial against E. coli O157:H7; however, NCMC and CMC films with SNG were highly antimicrobial. After 5 days at 8°C, E. coli O157:H7 was reduced more than 4 log10 by the NCMC•pSNG film and this reduction remained almost the same until 18 days at 8°C when E. coli O157:H7 was reduced >5 log10 CFU g(-1) meat.
    In vivo:
    PLoS One. 2014 Oct 20;9(10):e110145.
    Anti-proliferative activities of sinigrin on carcinogen-induced hepatotoxicity in rats.[Pubmed: 25329483]
    Liver cancer is one of the leading causes of cancer death worldwide. A very high incidence of new liver cancer cases is diagnosed every year, and metastasis has been found to correlate to poor prognoses in humans. Better treatments for liver cancer are thus clearly needed. Sinigrin is one of the major ingredients present in Brassica nigra, which has been used in combination with other herbs for treatment of various diseases.
    METHODS AND RESULTS:
    The anti-proliferative activities of sinigrin were studied in a model of carcinogen-induced hepatotoxicity in rats. Rats were orally administered with sinigrin on a daily basis for three months before sacrifice. Sinigrin was found to significantly inhibit the proliferation of liver tumor cells; the number of surface tumors in the rat liver was dramatically reduced. Sinigrin induced apoptosis of liver cancer cells through up-regulation of p53 and down-regulation of Bcl-2 family members and caspases. Our findings indicated that the liver functions were gradually restored after treatment with sinigrin and that the agent did not cause liver toxicity. Cell cycle analysis indicated that sinigrin caused cell cycle arrest in G0/G1 phase.
    CONCLUSIONS:
    The results suggest that sinigrin exerts important anti-proliferative activities in carcinogen-induced hepatocarcinogenesis in rats, and highlight the potential of sinigrin as an anti-cancer agent for liver cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5157 mL 12.5786 mL 25.1572 mL 50.3145 mL 62.8931 mL
    5 mM 0.5031 mL 2.5157 mL 5.0314 mL 10.0629 mL 12.5786 mL
    10 mM 0.2516 mL 1.2579 mL 2.5157 mL 5.0314 mL 6.2893 mL
    50 mM 0.0503 mL 0.2516 mL 0.5031 mL 1.0063 mL 1.2579 mL
    100 mM 0.0252 mL 0.1258 mL 0.2516 mL 0.5031 mL 0.6289 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4-(α-L-鼠李糖基)苄基芥子油苷; Glucomoringin CFN00496 316165-49-8 C20H28KNO14S2 = 609.7 5mg QQ客服：215959384
    芸苔葡糖硫苷; Glucobrassicin CFN00484 143231-38-3 C16H19KN2O9S2 = 486.6 5mg QQ客服：2056216494
    1-甲氧基-3-吲哚基甲基硫代葡萄糖苷; Neoglucobrassicin CFN00503 5187-84-8 C17H21KN2O10S2 = 516.6 5mg QQ客服：2056216494
    4-羟基吲哚基-3-甲基硫苷; 4-Hydroxyglucobrassicin CFN00504 83327-20-2 C16H19KN2O10S2 = 502.6 5mg QQ客服：3257982914
    4-甲氧基吲哚基-3-甲基硫苷; 4-Methoxyglucobrassicin CFN00505 83327-21-3 C17H21KN2O10S2 = 516.6 5mg QQ客服：3257982914
    间甲氧基苄基芥子油苷; Glucolimnanthin CFN00483 111810-95-8 C15H20KNO10S2 = 477.6 5mg QQ客服：3257982914
    豆瓣菜苷; Gluconasturtiin CFN00489 18425-76-8 C15H20KNO9S2 = 461.6 5mg QQ客服：1413575084
    Glucobarbarin; Glucobarbarin CFN00497 21087-78-5 C15H20KNO10S2 = 477.6 5mg QQ客服：215959384
    3-甲基亚硫酰丙基硫苷; Glucoiberin CFN00486 15592-34-4 C11H20KNO10S3 = 461.6 5mg QQ客服：1457312923
    桂竹香苷; Glucocheirolin CFN00487 15592-36-6 C11H20KNO11S3 = 477.6 5mg QQ客服：1457312923

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