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  • 西伯利亚远志糖A5

    Sibiricose A5

    西伯利亚远志糖A5
    产品编号 CFN90645
    CAS编号 107912-97-0
    分子式 = 分子量 C22H30O14 = 518.5
    产品纯度 >=98%
    物理属性 Solid
    化合物类型 Phenylpropanoids
    植物来源 The roots of Polygala tenuifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    西伯利亚远志糖A5 CFN90645 107912-97-0 10mg QQ客服:2056216494
    西伯利亚远志糖A5 CFN90645 107912-97-0 20mg QQ客服:2056216494
    西伯利亚远志糖A5 CFN90645 107912-97-0 50mg QQ客服:2056216494
    西伯利亚远志糖A5 CFN90645 107912-97-0 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Aveiro University (Portugal)
  • Uniwersytet Gdański (Poland)
  • Imperial College London (United Kingdom)
  • Universite de Lille1 (France)
  • Nanjing University of Chinese Medicine (China)
  • Universidad Veracuzana (Mexico)
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  • Weizmann Institute of Science (Israel)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biol Chem.2014, 289(3):1723-31
  • J of L. Chroma.&Related Tech2017, 252-258
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Molecules2022, 27(3),1140.
  • Drug Dev Res.2020, doi: 10.1002
  • Applied Biological Chemistry2021, 64(4)
  • Universitat Stuttgart2022, opus-12200.
  • Functional Ecology2020, doi: 10.1111.
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • J Ethnopharmacol.2017, 198:91-97
  • Plant Cell Tiss Org2017, 479-486
  • J Pharm Biomed Anal.2019, 172:268-277
  • Biofactors.2018, 44(2):168-179
  • Acta Chromatographica2016, 29(3)
  • Molecules.2017, 22(6)
  • Toxicol In Vitro.2019, 59:161-178
  • Front Immunol. 2020, 11:62.
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • Biomol Ther (Seoul).2023, 31(1):40-47.
  • Tumour Biol.2015, 36(9):7027-34
  • Sci Rep. 2017, 12953(7)
  • Sustainability2021, 13(23),12981.
  • ...
  • 生物活性
    Description: Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia.
    Targets: Dehydrogenase
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(11):1278-80.
    Study on antidepressant components of sucrose ester from Polygala tenuifolia.[Pubmed: 18831206]
    To investigate the antidepressant components of Polygala tenuifolia.
    METHODS AND RESULTS:
    The chromatographic method was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities. Nine compounds were isolated from the roots of P. tenuifolia. Their structures were identified as sibiricose A, (1), sibiricose A5 (2), tenuifoliside A (3) and 3', 6-disinapoyl sucrose (4), sibiricose A6 (5), 3, 4, 5-trimethoxycinnamate (6), polygalaxanthone III (7), tenuifolioses A (8), tenuifolioses H (9) and some compounds' activities to PC12 were observed.
    CONCLUSIONS:
    Compound 1 was isolated from this plant for the first time. Compounds 2,3 could protect PC12 cells damage induced by P. tenuifolia.
    Talanta. 2015 Nov 1;144:830-5.
    Indirect identification of antioxidants in Polygalae Radix through their reaction with 2,2-diphenyl-1-picrylhydrazyl and subsequent HPLC-ESI-Q-TOF-MS/MS.[Pubmed: 26452897 ]
    A rapid and efficient method for the identification of antioxidants in the traditional Chinese medicine Polygalae Radix (PR) by HPLC-ESI-Q-TOF-MS/MS is described.
    METHODS AND RESULTS:
    The method is based on the hypothesis that upon reaction of antioxidants with 1,1-diphenyl-2-picrylhydrazyl (DPPH), the peak areas of compounds with potential antioxidant activities in the HPLC chromatogram will be significantly reduced in comparison to the untreated sample. The identity confirmation was achieved by Q-TOF-MS/MS technique. With this method, eight components were proposed possessing potent antioxidant activity. They were identified as sibiricose A5, sibiricose A6, sucrose monoester, polygalaxanthone III, tenuifoliside B, 3',6-disinapoylsucrose (DISS), sucrose diester, tenuifoliside C, respectively. DISS was proposed to be the most potent one. The antioxidant activity of DISS was evaluated by DPPH, ABTS radical scavenging assay and ferric-reducing antioxidant power (FRAP) assay in vitro. Vitamin C (Vc) was used as positive control substance. DISS showed moderate DPPH (DISS's IC50 value was 1024.17 μg/mL, Vc's was 294.68 μg/mL) and ABTS (IC50 324.13 μg/mL, Vc's was 117.50 μg/mL) free radical scavenging capacity and ferric-reducing antioxidant power.
    CONCLUSIONS:
    DISS can be used as a new source of natural antioxidant in foods and cosmetics.
    In vivo:
    Molecules. 2011 Jun 29;16(7):5507-13.
    Absorbable phenylpropenoyl sucroses from Polygala tenuifolia.[Pubmed: 21716172]

    METHODS AND RESULTS:
    Three phenylpropenoyl sucroses--sibiricose A5, A6 and 3',6-disinapoyl sucrose--were isolated from the 30% EtOH extract of Polygala tenuifolia, which displayed antidepressant-like action.
    CONCLUSIONS:
    HPLC analysis indicated that the three phenylpropenoyl sucroses could be absorbed into serum. From the serum pharmacochemistry point of view, these three phenylpropenoyl sucroses might prevent or relieve depression.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9286 mL 9.6432 mL 19.2864 mL 38.5728 mL 48.216 mL
    5 mM 0.3857 mL 1.9286 mL 3.8573 mL 7.7146 mL 9.6432 mL
    10 mM 0.1929 mL 0.9643 mL 1.9286 mL 3.8573 mL 4.8216 mL
    50 mM 0.0386 mL 0.1929 mL 0.3857 mL 0.7715 mL 0.9643 mL
    100 mM 0.0193 mL 0.0964 mL 0.1929 mL 0.3857 mL 0.4822 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    焦地黄苯乙醇甙A1; Jionoside A1 CFN90809 120444-60-2 C36H48O20 = 800.8 5mg QQ客服:215959384
    焦地黄苯乙醇甙B1; Jionoside B1 CFN90729 120406-37-3 C37H50O20 = 814.78 5mg QQ客服:2159513211
    管花苷A; Tubuloside A CFN90669 112516-05-9 C37H48O21 = 828.76 5mg QQ客服:3257982914
    管花苷B; Tubuloside B CFN91712 112516-04-8 C31H38O16 = 666.6 10mg QQ客服:2056216494
    管花肉苁蓉苷C1; Cistantubuloside C1 CFN95121 620632-36-2 C35H46O21 = 802.7 10mg QQ客服:215959384
    肉苁蓉苷A; Cistanoside A CFN90526 93236-42-1 C36H48O20 = 800.75 20mg QQ客服:2159513211
    安格洛苷C; 安格洛甙C; Angoroside C CFN98149 115909-22-3 C36H48O19 = 784.75 20mg QQ客服:2159513211
    Teupolioside; Teupolioside CFN70272 143617-02-1 C35H46O20 = 786.7 5mg QQ客服:1457312923
    2-肉桂酰葡萄糖苷; 2-O-cinnamoyl-beta-D-glucose CFN95111 N/A C15H18O7 = 310.3 5mg QQ客服:3257982914
    6-O-(E)-咖啡酰基葡萄糖苷; 6-O-(E)-Caffeoylglucopyranose CFN95105 209797-79-5 C15H18O9 = 342.3 5mg QQ客服:1457312923

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