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    • 莽草酸

    Shikimic acid

    莽草酸
    		产品编号 CFN99436
    CAS编号 138-59-0
    分子式 = 分子量 C7H10O5 = 174.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The fruits of Illicium verum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    莽草酸 CFN99436 138-59-0 10mg QQ客服：3257982914
    莽草酸 CFN99436 138-59-0 20mg QQ客服：3257982914
    莽草酸 CFN99436 138-59-0 50mg QQ客服：3257982914
    莽草酸 CFN99436 138-59-0 100mg QQ客服：3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Maryland (USA)
  • John Innes Centre (United Kingdom)
  • National Cancer Center Research Institute (Japan)
  • Agricultural Research Organization (ARO) (Israel)
  • National Research Council of Canada (Canada)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Complutense University of Madrid (Spain)
  • Ain Shams University (Egypt)
  • Lodz University of Technology (Poland)
  • Universitas Airlangga (Indonesia)
  • The Ohio State University (USA)
  • National Hellenic Research Foundation (Greece)
  • University of Limpopo (South Africa)
  • University of East Anglia (United Kingdom)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • Curr Top Med Chem.2020, 20(21):1898-1909.
  • Applied Physics B2021, 127(92).
  • Pharmaceutics.2021, 13(7):1028.
  • United States Patent Application2020, 20200038363
  • Biomolecules2021, 11(10),1513.
  • Chem Biol Interact.2016, 258:59-68
  • ACS Omega.2021, 6(36):23460-23474.
  • Enzyme Microb Technol.2022, 161:110111.
  • Legume Science2021, 3(4): e101.
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • Antioxidants (Basel).2021, 10(9):1435.
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Nat Prod Sci.2019, 25(3):238
  • Applied Biological Chemistry2020, 63:37.
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • J of L. Chroma.&Related Tech2017, 252-258
  • Environ Toxicol.2019, 34(12):1354-1362
  • Plant Pathology2022, 10.1111:ppa.13651.
  • J Applied Biological Chemistry2021, 64(2):185-192
  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • Phytother Res.2022, 10.1002:ptr.7602.
  • J Mol Histol.2019, 50(4):343-354
  • ...
    • 生物活性
    Description: Shikimic acid(Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms, has great potential for the design and synthesis of enzyme inhibitors. It reversed the H2O2 induced oxidative damage in hepatocytes, probably through the inhibition of NF-κB, with the activation of PI3K/Akt/Nrf2 pathway and reduction of apoptosis by interfering the SAPK/JNK/Bax pathway; it also profoundly inhibited pancreatic lipase activity by 66%, thus providing another valuable therapeutic aspect for treating diet induced obesity in humans.
    Targets: ROS | NF-kB | JNK | Bcl-2/Bax | Nrf2 | SAPK | Akt
    In vitro:
    Antonie Van Leeuwenhoek. 2015 Feb;107(2):419-31.
    Shikimic acid, a base compound for the formulation of swine/avian flu drug: statistical optimization, fed-batch and scale up studies along with its application as an antibacterial agent.[Pubmed: 25563634]
    The sudden outbreak of swine flu has increased the global demand of shikimic acid which is an industrially interesting compound, as it is used as a key starting material for the synthesis of a neuraminidase inhibitor Tamiflu(®), for the treatment of antiviral infections such as swine flu.
    METHODS AND RESULTS:
    Statistical optimization and evaluation of medium components for the production of shikimic acid by Citrobacter freundii is addressed in the present investigation. Plackett-Burman design was applied for the screening of the most significant variables affecting shikimic acid production, where glucose, asparagine, KH2PO4, CaCO3 and agitation rate were the most significant factors. Response surface methodology was also employed to study the interaction among the most significant variables through which shikimic acid production increased to 12.76 g/L. Further, fed-batch studies resulted in the production of 22.32 g/L of shikimic acid. The scalability of the process was also confirmed by running 14 L bioreactor (7.5 L production medium) where 20.12 g/L of shikimic acid was produced.
    CONCLUSIONS:
    In addition the antibacterial activity of the shikimic acid produced was analysed against four Gram positive and four Gram negative bacteria and it was found to have a greater inhibition effect against the Gram negative bacteria.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.7405 mL 28.7026 mL 57.4053 mL 114.8106 mL 143.5132 mL
    5 mM 1.1481 mL 5.7405 mL 11.4811 mL 22.9621 mL 28.7026 mL
    10 mM 0.5741 mL 2.8703 mL 5.7405 mL 11.4811 mL 14.3513 mL
    50 mM 0.1148 mL 0.5741 mL 1.1481 mL 2.2962 mL 2.8703 mL
    100 mM 0.0574 mL 0.287 mL 0.5741 mL 1.1481 mL 1.4351 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-O-咖啡酰莽草酸; 5-O-Caffeoylshikimic acid CFN92950 73263-62-4 C16H16O8 = 336.29 10mg QQ客服：2159513211
    腐殖酸钠; Humic acid sodium salt CFN99794 68131-04-4 C9H8O4Na2 = 226.14 20mg QQ客服：2159513211
    去氧野艽霉素盐酸盐; Deoxynojirimycin hydrochloride CFN90484 73285-50-4 C6H14ClNO4 = 199.6 5mg QQ客服：2056216494
    环己五醇, L-栎醇; vibo-Quercitol CFN98778 488-76-6 C6H12O5 = 164.2 20mg QQ客服：2056216494
    肌醇; Inositol CFN91718 87-89-8 C6H12O6 = 180.16 20mg QQ客服：1413575084
    (E)-1-甲氧基-2-O-(p-香豆酰)-myo-肌醇; (E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol CFN95609 1391715-18-6 C16H20O8 = 340.3 20mg QQ客服：1413575084
    D-松醇; D-Pinitol CFN99044 10284-63-6 C7H14O6 = 194.2 20mg QQ客服：3257982914
    (-)-白雀木醇; L-Quebrachitol CFN90586 642-38-6 C7H14O6 = 194.18 5mg QQ客服：3257982914
    牛弥菜醇A; Conduritol A CFN98868 526-87-4 C6H10O4 = 146.1 10mg QQ客服：1457312923
    D-(-)-奎宁酸; D-(-)-Quinic acid CFN99930 77-95-2 C7H12O6 = 192.17 20mg QQ客服：215959384

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