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  • 常绿钩吻碱

    Sempervirine

    常绿钩吻碱
    产品编号 CFN97173
    CAS编号 6882-99-1
    分子式 = 分子量 C19H16N2 = 272.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Alkaloids
    植物来源 The herbs of Gelsemium elegans
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    常绿钩吻碱 CFN97173 6882-99-1 1mg QQ客服:1457312923
    常绿钩吻碱 CFN97173 6882-99-1 5mg QQ客服:1457312923
    常绿钩吻碱 CFN97173 6882-99-1 10mg QQ客服:1457312923
    常绿钩吻碱 CFN97173 6882-99-1 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Florida International University (USA)
  • Tohoku University (Japan)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Sri Ramachandra University (India)
  • China Medical University (Taiwan)
  • Melbourne University (Australia)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Kyushu University (Japan)
  • Helmholtz Zentrum München (Germany)
  • University of Beira Interior (Portugal)
  • Shanghai University of TCM (China)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2017, 17(1):393
  • Molecules.2023, 28(16):6025.
  • Phytomedicine.2021, 83:153483.
  • Molecules.2019, 24(22):E4022
  • RSC Advances2017, 86
  • Foods.2021, 10(12):2929.
  • Agronomy 2021, 11(3),502.
  • Applied Biological Chemistry 2022, 65,5(2022).
  • Archives of Biological sciences2022, 00:21-21
  • Sci Rep.2019, 9(1):4646
  • Biol Pharm Bull.2017, 40(6):797-806
  • Pharmaceutics.2022, 14(5):945.
  • Front Pharmacol.2020, 11:566490.
  • Microb Biotechnol.2021, 14(5):2009-2024.
  • Journal of Apicultural Research2021, 60(1).
  • ARPN Journal of Eng.& Applied Sci.2016, 2199-2204
  • J Ethnopharmacol.2017, 198:91-97
  • Pamukkale Medical Journal2022, 15(4):796-803.
  • Phytomedicine.2022, 110:154597.
  • Korean J of Crop Science2019, 452-458
  • J Chromatogr A.2022, 1685:463640.
  • Molecules.2020 ,25(16):3697.
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • ...
  • 生物活性
    Description: Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .
    Targets: DNA/RNA Synthesis
    In vitro:
    Exp Cell Biol. 1982;50(2):79-87.
    Selective inhibition of in vitro synthesis of cancer DNA by alkaloids of beta-carboline class.[Pubmed: 7075859]

    METHODS AND RESULTS:
    The high template in vitro activity of native DNA from cancerous mammalian and plant tissues, compared to DNA from healthy tissues, enabled us to select substances which selectively inhibit cancer DNA synthesis. Among them, alstonine, serpentine, Sempervirine and flavopereirine, all alkaloids which belong to the Beta-carboline class, distinguish cancer DNA from healthy tissue DNA inhibit DNA in vitro synthesis when native DNA from different cancerous tissues or cells is used as template. They have practically no effect on DNA from healthy tissues. The inhibitory effect of alkaloids is due to their capacity to form an 'alkaloid-cancer DNA' complex which has been characterized by use of the Sephadex column.
    CONCLUSIONS:
    Evidence is presented showing that these alkaloids inhibit the initiation of DNA synthesis but not chain elongation. The stimulating action caused by carcinogens during cancer DNA in vitro synthesis may be prevented and reversed by alkaloids. Furthermore, the stimulating action of steroids during in vitro synthesis of hormone target tissue DNA might be neutralized by alkaloids. However, at relatively high doses, steroids reversibly compete with alkaloids for binding sites on breast cancer DNA. This is not observed with DNA from nonhormone target tissues.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6711 mL 18.3554 mL 36.7107 mL 73.4214 mL 91.7768 mL
    5 mM 0.7342 mL 3.6711 mL 7.3421 mL 14.6843 mL 18.3554 mL
    10 mM 0.3671 mL 1.8355 mL 3.6711 mL 7.3421 mL 9.1777 mL
    50 mM 0.0734 mL 0.3671 mL 0.7342 mL 1.4684 mL 1.8355 mL
    100 mM 0.0367 mL 0.1836 mL 0.3671 mL 0.7342 mL 0.9178 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    常绿钩吻碱; Sempervirine CFN97173 6882-99-1 C19H16N2 = 272.4 5mg QQ客服:1457312923
    别育享宾; Allo-Yohimbine CFN92577 522-94-1 C21H26N2O3 = 354.5 5mg QQ客服:1413575084
    利血平酸甲酯; Methyl reserpate CFN92579 2901-66-8 C23H30N2O5 = 414.5 5mg QQ客服:2056216494
    利血那明; Reserpinine CFN92580 24815-24-5 C35H42N2O9 = 634.7 5mg QQ客服:1457312923
    利血平氮氧化物; Reserpin N-oxide CFN92583 474-48-6 C33H40N2O10 = 624.7 5mg QQ客服:2159513211
    18-β-羟基-3-表-α-育亨宾; 18-Beta-hydroxy-3-epi-alpha-yohimbine CFN92610 81703-06-2 C21H26N2O4 = 370.5 5mg QQ客服:1457312923
    利血平; Reserpine CFN98112 50-55-5 C33H40N2O9 = 608.69 20mg QQ客服:2056216494
    羧酯利血平; Syrosingopine CFN98542 84-36-6 C35H42N2O11 = 666.71 5mg QQ客服:2056216494
    异柯楠碱; Isorauhimbine CFN98762 483-09-0 C21H26N2O3 = 354.5 5mg QQ客服:215959384
    β-育亨宾; beta-Yohimbine CFN98921 549-84-8 C21H26N2O3 = 354.5 5mg QQ客服:215959384

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